Andrias davidianus(Chinese giant salamander,CGS)is the largest and oldest extant amphibian species in the world and is a source of prospective functional food in China.However,the progress of functional peptides minin...Andrias davidianus(Chinese giant salamander,CGS)is the largest and oldest extant amphibian species in the world and is a source of prospective functional food in China.However,the progress of functional peptides mining was slow due to lack of reference genome and protein sequence data.In this study,we illustrated full-length transcriptome sequencing to interpret the proteome of CGS meat and obtain 10703 coding DNA sequences.By functional annotation and amino acid composition analysis,we have discovered various genes related to signal transduction,and 16 genes related to longevity.We have also found vast variety of functional peptides through protein coding sequence(CDS)analysis by comparing the data obtained with the functional peptide database.Val-Pro-Ile predicted by the CDS analysis was released from the CGS meat through enzymatic hydrolysis,suggesting that our approach is reliable.This study suggested that transcriptomic analysis can be used as a reference to guide polypeptide mining in CGS meat,thereby providing a powerful mining strategy for the bioresources with unknown genomic and proteomic sequences.展开更多
Acupuncture is an effective treatment for ischemic stroke(IS)and plays a key role in neurological rehabilitation after IS.Acupuncture can improve the clinical symptoms of various complications after IS,including motor...Acupuncture is an effective treatment for ischemic stroke(IS)and plays a key role in neurological rehabilitation after IS.Acupuncture can improve the clinical symptoms of various complications after IS,including motor dysfunction,swallowing disorders,speech disorders,cognitive impairment,depression,insomnia,and fatigue.However,the mechanisms underlying the effects of acupuncture in IS remain unclear.Available evidence suggests that acupuncture may exert neuroprotective effects through neuroplasticity(neurogenesis and synaptogenesis),angiogenesis,cell proliferation and apoptosis,and regulation of oxidative stress,inflammation,and immunity.Further studies should be conducted to improve the high-quality evidence-based system of acupuncture intervention for IS,by focusing on the clinical and basic research design,increasing the sample size,standardizing and quantifying the standards of acupuncture operations,using multidisciplinary techniques and methods to systematically explore the key targets of acupuncture intervention for IS,and reveal the efficacy and mechanism of acupuncture in the treatment of IS.展开更多
The error caused by irreversible demagnetization damages the accurate velocity tracking of an in-wheel motor in a mobile robot.A current feedforward vector control system based on ESO is proposed to compensate it for ...The error caused by irreversible demagnetization damages the accurate velocity tracking of an in-wheel motor in a mobile robot.A current feedforward vector control system based on ESO is proposed to compensate it for the demagnetization motor.A demagnetization mathematical model is established to describe a permanent magnet synchronous motor,which took the change of permanent magnet flux linkage parameters as a factor to count the demagnetization error in velocity tracking.The uncertain disturbance estimation model of the control system is built based on ESO,which eliminates the system error by the feedforward current compensation.It is compared with the vector control method in terms of control accuracy.The simulation results show that the current feedforward vector control method based on ESO reduces the velocity tracking error greatly in conditions of motor demagnetization less than 30%.It is effective to improve the operation accuracy of the mobile robot.展开更多
Colorectal cancer(CRC)represents a considerable global health challenge,ranking third in incidence and second in mortality worldwide.However,existing therapies for diseases with advanced stages often fail,thereby nece...Colorectal cancer(CRC)represents a considerable global health challenge,ranking third in incidence and second in mortality worldwide.However,existing therapies for diseases with advanced stages often fail,thereby necessitating the search for more comprehensive treatments.Oncolytic virus,a novel anticancer approach,exhibits promising capabilities in selectively targeting and destroying tumor cells while augmenting their efficacy through genetic engineering modifications.Anticipated as a new therapeutic paradigm for CRC,this study aimed to assess the performance of oncolytic virus in clinical trials and explore their potential synergies with other therapeutic modalities,offering insights into the future direction of CRC treatment.展开更多
With the acceleration of urbanization and the improvement of people’s living standards,people have increasingly higher requirements for the living environment,especially in the design of outdoor balconies.However,exi...With the acceleration of urbanization and the improvement of people’s living standards,people have increasingly higher requirements for the living environment,especially in the design of outdoor balconies.However,existing landscape balconies generally suffer from insufficient shading and rainwater drainage problems,which affects people’s living experience.In response to this problem,this article proposes a new design scheme for building landscape balconies to solve the existing problems of landscape balconies.This design plan fully considers the user’s usage needs and scenarios,improves the use value and comfort of the balcony through technical means,and achieves intelligence and functionality.展开更多
In this study,we investigate the solar cycle dependence of the sunrise ionospheric zonal electric fields at the equator under geomagnetically quiet conditions.Simulations using the Thermosphere–Ionosphere–Electrodyn...In this study,we investigate the solar cycle dependence of the sunrise ionospheric zonal electric fields at the equator under geomagnetically quiet conditions.Simulations using the Thermosphere–Ionosphere–Electrodynamics General Circulation Model(TIEGCM)reveal that the equatorial eastward electric field at sunrise decreases with the increase in solar activity,independent of longitude,season,and lower atmospheric tides.The solar cycle dependence of the sunrise zonal electric field is mainly related to the zonal wind dynamo.Moreover,this solar cycle dependence of sunrise electric fields at the equator is dominated by the corresponding variation in the F-region dynamo because the response of conductivity and neutral winds near sunrise to increasing solar flux is stronger in the F-region than in the E-region,although the sunrise eastward enhancement of electric fields is mainly driven by the E-region zonal wind dynamo.Specifically,the westward gradient of low-latitude F-region neutral winds near the dawn terminator tends to produce westward electric fields in the equatorial region that are more pronounced at solar maximum,whereas the midlatitude E-region dynamo induces an eastward enhancement of sunrise electric fields at the equator that decreases slightly with increasing solar activity.This study also reveals that the reason the eastward enhancement of equatorial zonal electric fields near dawn and dusk terminators show opposite solar cycle dependence is because of their different generation mechanisms.展开更多
Cancer-related diseases represent the second overall cause of death worldwide.Human papilloma virus(HPV)is an infectious agent which is mainly sexually transmitted and may lead to HPV-associated cancers in both men an...Cancer-related diseases represent the second overall cause of death worldwide.Human papilloma virus(HPV)is an infectious agent which is mainly sexually transmitted and may lead to HPV-associated cancers in both men and women.Almost all cervical cancers are HPV-associated,however,an increasing number of head and neck cancers(HNCs),especially oropharyngeal cancer,can be linked to HPV infection.Moreover,anogenital cancers,including vaginal,vulvar,penial,and anal cancers,represent a subset of HPVrelated cancers.Whereas testing and prevention of cervical cancer have significantly improved over past decades,anogenital cancers remain more difficult to confirm.Current clinical trials including patients with HPV-related cancers focus on finding proper testing for all HPV-associated cancers as well as improve the currently applied treatments.The HPV viral oncoproteins,E6 and E7,lead to degradation of,respectively,p53 and pRb resulting in entering the S phase without G1 arrest.These high-risk HPV viral oncogenes alter numerous cellular processes,including DNA repair,angiogenesis,and/or apoptosis,which eventually result in carcinogenesis.Additionally,a comprehensive analysis of gene expression and alteration among a panel of DNA double strand breaks(DSB)repair genes in HPV-negative and HPV-positive HNC cancers reveals differences pointing to HPV-dependent modifications of DNA repair processes in these cancers.In this review,we discuss the current knowledge regarding HPV-related cancers,current screening,and treatment options as well as DNA damage response-related biological aspects of the HPV infection and clinical trials.展开更多
Depression is closely linked to the morphology and functional abnormalities of multiple brain regions; however, its topological structure throughout the whole brain remains unclear. We col- lected resting-state functi...Depression is closely linked to the morphology and functional abnormalities of multiple brain regions; however, its topological structure throughout the whole brain remains unclear. We col- lected resting-state functional MRI data from 36 first-onset unmedicated depression patients and 27 healthy controls. The resting-state functional connectivity was constructed using the Auto- mated Anatomical Labeling template with a partial correlation method. The metrics calculation and statistical analysis were performed using complex network theory. The results showed that both depressive patients and healthy controls presented typical small-world attributes. Compared with healthy controls, characteristic path length was significantly shorter in depressive patients, suggesting development toward randomization. Patients with depression showed apparently abnormal node attributes at key areas in cortical-striatal-pallidal-thalamic circuits. In addition, right hippocampus and right thalamus were closely linked with the severity of depression. We se- lected 270 local attributes as the classification features and their P values were regarded as criteria for statistically significant differences. An artificial neural network algorithm was applied for classification research. The results showed that brain network metrics could be used as an effec- tive feature in machine learning research, which brings about a reasonable application prospect for brain network metrics. The present study also highlighted a significant positive correlation between the importance of the attributes and the intergroup differences; that is, the more sig- nificant the differences in node attributes, the stronger their contribution to the classification. Experimental findings indicate that statistical significance is an effective quantitative indicator of the selection of brain network metrics and can assist the clinical diagnosis of depression.展开更多
Brain structure and cognitive function change in the temporal lobe, hippocampus, and prefrontal cortex of patients with mild cognitive impairment and Alzheimer's disease, and brain network-connection strength, networ...Brain structure and cognitive function change in the temporal lobe, hippocampus, and prefrontal cortex of patients with mild cognitive impairment and Alzheimer's disease, and brain network-connection strength, network efficiency, and nodal attributes are abnormal. However, existing research has only analyzed the differences between these patients and normal controls. In this study, we constructed brain networks using resting-state functional MRI data that was extracted from four populations (nor- mal controls, patients with early mild cognitive impairment, patients with late mild cognitive impairment, and patients with Alzheimer's disease) using the Alzheimer's Disease Neuroimaging Initiative data set. The aim was to analyze the characteristics of resting-state functional neural networks, and to observe mild cognitive impairment at different stages before the transformation to Alzheimer's disease. Results showed that as cognitive deficits increased across the four groups, the shortest path in the rest- ing-state functional network gradually increased, while clustering coefficients gradually decreased. This evidence indicates that dementia is associated with a decline of brain network efficiency. In addi- tion, the changes in functional networks revealed the progressive deterioration of network function across brain regions from healthy elderly adults to those with mild cognitive impairment and AIz- heimer's disease. The alterations of node attributes in brain regions may reflect the cognitive functions in brain regions, and we speculate that early impairments in memory, hearing, and language function can eventually lead to diffuse brain injury and other cognitive impairments.展开更多
Catalytic hydrogenation of furfural to furfuryl alcohol is an important upgrading process for valorization of biomass-derived furanyl platform molecules.However,selective hydrogenation of a,b-unsaturated aldehydes lik...Catalytic hydrogenation of furfural to furfuryl alcohol is an important upgrading process for valorization of biomass-derived furanyl platform molecules.However,selective hydrogenation of a,b-unsaturated aldehydes like furfural to the corresponding alcohols at ambient pressure remains challenging in sustainable chemistry.Till date heterogeneous Au hydrogenation catalyst has been scarcely reported for this reaction due to the low reactivity of Au for H_(2)dissociation.In this work,we showed that Au nanoparticles(loading:0.2 wt%)with a mean size of about 3 nm supported on Cu-doped Al_(2)O_(3)can efficiently hydrogenate furfural to furfuryl alcohol in liquid phase at ambient pressure.We demonstrated that doping a small amount of Cu(2 mol%)to g-Al_(2)O_(3)may modify the Lewis acidity-basicity of Al_(2)O_(3)and simultaneously induce the presence of sufficient Cu^(+) species on surface,which facilitated the hydrogen transfer from i-PrOH to furfural.Moreover,we observed an enhanced reactivity of Au toward molecular H_(2)via cooperation with the Lewis acidic-basic Cu_(2)O-Al_(2)O_(3)support.Hence,100%yield to furfuryl alcohol with a productivity of 0.98 g_(FA),h^(-1),g^(-1)_(cat.)at 120C and 0.1 MPa H_(2)can be obtained.The prepared Au/Cu-Al_(2)O_(3)catalyst was found reusable and was effective to the concentrated furfural solution,as well as several typical unsaturated aldehydes.展开更多
The role of gut microbiota in terms of host health is becoming increasingly important.In this study,the comparative effects of tea polyphenols(TPs)on weight loss and lipid metabolism on conventionalized mice(CVZ)and p...The role of gut microbiota in terms of host health is becoming increasingly important.In this study,the comparative effects of tea polyphenols(TPs)on weight loss and lipid metabolism on conventionalized mice(CVZ)and pseudo germ-free(PGF)mice(treated with antibiotics)were investigated.Our findings revealed that high fat(HF)diet considerably increased the body weight,total fat and upsurge lipid indices in CVZ mice but PGF mice were not sensitive to the effect of HF diet as CVZ mice.After the dietary administration of TP,body weight,perirenal fat and epididymal fat,liver weight,glucose(GLU)level,total chloestrol(TC level),high density lipoprotein-cholesterol(HDL-C)level significantly lowered in PGF mice as compared to CVZ mice group.However,the area of fat cells and triglyceride(TG)level were significantly increased in PGF mice.In CVZ mice,TP intervention resulted in a considerable drop in the Firmicutes/Bacteroides ratio as compared to PGF mice.The intestinal flora of PGF mice was severely reduced after antibiotic treatment,while TP administration restored intestinal diversity;the abundance of Akkermansia and Lactobacillus increased,whereas the abundance of Enterobacteriaceae and Prevotella reduced.Overall,we can assume that PGF obese mice administered with TP have less anti-obesity effects compared to obese CVZ mice.展开更多
Constructing heterostructures is an important approach to develop high-performance anode materials for sodium ion batteries(SIBs).The abundant phase interfaces provide numerous defects and active sites for rapid elect...Constructing heterostructures is an important approach to develop high-performance anode materials for sodium ion batteries(SIBs).The abundant phase interfaces provide numerous defects and active sites for rapid electron/ion transport.Herein,CoSe_(2)■NC@NC/MoS_(2) heterostructures are prepared through a multi-step reaction strategy,CoSe_(2) nanoparticles served as the coating shells for MoS_(2) cores are anchored in carbon frameworks.The core–shell structure effectively buffers the double volume expansion and inhibits the dissolution of MoS_(2) and CoSe_(2) in the electrolyte.AsSIBs anodes,the heterostructure delivers a high reversible capacity of 481.6 m Ah g^(-1) at 0.5 A g^(-1) after 100 cycles,superior rate capability(174.5 m Ah g^(-1) at 20.0 A g^(-1)),excellent long-term cycle performance(333.4 m Ah g^(-1) after 2000 cycles at 5.0 A g^(-1)).The DFT calculation proves that the electronic distribution of heterostructures is reconstructed with enhanced conductivity.The kinetic analysis,mechanism characterizations and full-cells tests exhibit the synergistic reaction mechanism among different components and practical application prospects.The heterostructure also shows more rapid ions diffusion kinetics than single components.展开更多
Disruption prediction using a long short-term memory(LSTM)algorithm has been developed on EAST,due to its inherent advantages in time series data processing.In the present work,LSTM is used as the model and the AUC(ar...Disruption prediction using a long short-term memory(LSTM)algorithm has been developed on EAST,due to its inherent advantages in time series data processing.In the present work,LSTM is used as the model and the AUC(area under receiver operation characteristic curve)is used as the evaluation index.When the model is trained on data from the plasma current flattop phase and tested on data from the same period multiple times,the highest AUC is 0.8646 and the training time is about 6900 s per epoch.For comparison,the last 1000 ms of the flattop phases are intercepted as short time sequences.When the model is trained on data from short time sequences and tested on data from the same period,the highest AUC is increased to 0.9379 and the training time is restricted to 36 s per epoch.When the best model trained on the short time sequences is applied to the flattop phase for testing,the AUC is up to 0.9189.The experiment results show that it is possible for LSTM to train the model on data from short time sequences and migrate the model to the entire flattop phase,with a shorter training time and higher AUC value.展开更多
Rheumatoid arthritis(RA)is a debilitating autoimmune disease that causes chronic pain and serious complications,presenting a significant challenge to treat.Promising approaches for treating RA involve signaling pathwa...Rheumatoid arthritis(RA)is a debilitating autoimmune disease that causes chronic pain and serious complications,presenting a significant challenge to treat.Promising approaches for treating RA involve signaling pathways modulation and targeted therapy.To this end,a multifunctional nanosystem,TPC-U@HAT,has been designed for RA therapy,featuring multitargeting,dual-stimuli response,and on-demand drug release capabilities.TPC-U@HAT is composed of a probe/prodrug TPC,a JAK1 kinase inhibitor upadacitinib,and the drug carrier HAT.TPC is composed of an aggregation-induced emission(AIE)-active NIR-II chromophore TPY and an NF-κB/NLRP3 inhibitor caffeic acid phenethyl ester(CAPE),connected via boronic ester bond which serves as the reactive-oxygen-species-responsive linker.The carrier,HAT,is created by grafting bone-targeting alendronate and hydrophobic tocopheryl succinate onto hyaluronic acid chains,which can encapsulate TPC and upadacitinib to form TPC-U@HAT.Upon intravenous injection into mice,TPC-U@HAT accumulates at inflamed lesions of RA through both active and passive targeting,and the overexpressed hyaluronidase and H_(2)O_(2) therein cleave the hyaluronic acid polymer chains and boronate bonds,respectively.This generates an AIE-active chromophore for detection and therapeutic evaluation of RA via both optoacoustic imaging and NIR-II fluorescent imaging and concomitantly releases CAPE and upadacitinib to exert efficacious therapy by inhibiting NF-κB/NLRP3 and JAK-STAT pathways.展开更多
Flexible-robust hydrogen-bonded organic frameworks(HOFs)are attracting increasing interest due to their excellent separation performance for important industrial gases,but the construction remains challenging.Herein,a...Flexible-robust hydrogen-bonded organic frameworks(HOFs)are attracting increasing interest due to their excellent separation performance for important industrial gases,but the construction remains challenging.Herein,a sticked-layer strategy is first proposed to construct a flexible-robust HOF,HOFFJU-8,from a donor(D)–π–acceptor(A)molecule 4,4′,4″,4‴-(pyrrolo[3,2-b]pyrrole-1,2,4,5-tetrayl)tetrabenzonitrile(DP-4CN).HOF-FJU-8 is amicroporous three-dimensional framework composed of two kinds of DP-4CN molecules,one acting as building units for the two-dimensional layer via C≡N···H–C hydrogen bond dimers and another as the sticks to link the layers along channels through D–Aπ···πinteractions.The activated framework HOF-FJU-8a possesses flexible-robust pore characteristics,as determined by the gas adsorption and in situ gas-loaded powder X-ray diffraction.HOF-FJU-8a exhibits adaptive adsorption and stronger binding affinity to C_(2)H_(2)rather than CO_(2)due to the flexible-robust nature,which can effectively separate acetylene and carbon dioxide mixtures.展开更多
The design and fabrication of electromagnetic interference shielding films with a novel structure to eliminate undesirable electromagnetic pollution is an important research direction.However,it is still a challenge t...The design and fabrication of electromagnetic interference shielding films with a novel structure to eliminate undesirable electromagnetic pollution is an important research direction.However,it is still a challenge to combine and organize nanofillers in different dimensions into the structured network in polymer-based electromagnetic interference(EMI)shielding composites.In this work,a sandwich struc-ture polyimide(PI)composite film with alternative 2D-MXene network and 1D-Silver nanowires(Ag NWs)network was prepared through the“electrospinning-immersion-hot pressing”method.With the increase of Ag NWs content,the EMI shielding effectiveness(SE)gradually increases while maintaining good flexibility and mechanical robustness.The EMI SE and the tensile strength of 150μm thick sand-wich composite film can reach up to 79.54 dB and 39.82 MPa,respectively.The prepared flexible and robust PI composite film with a sandwich structure has high EMI SE with less metal content,which can provide guidelines for the development of high-performance EMI polymeric films with potentials in wearable devices and equipment.展开更多
Anodic oxygen evolution reaction(OER)is essential to participate in diverse renewable energy conversion and storage processes,while most OER electrocatalysts present satisfactory catalytic performance in only alkaline...Anodic oxygen evolution reaction(OER)is essential to participate in diverse renewable energy conversion and storage processes,while most OER electrocatalysts present satisfactory catalytic performance in only alkaline or acidic medium,limiting their practical applications in many aspects.Herein,we have designed and prepared Ir-CeO_(2)-C nanofibers(NFs)via an electrospinning and a relatively low-temperature calcination strategy for OER application in both alkaline and acidic conditions.Density functional theory(DFT)simulations demonstrate the high catalytic active sites of Ir atoms for OER,that the formation of Ir–O bonds at the interface between Ir and CeO_(2)can modulate the electron density of the relevant Ir atoms to promote the OER activity.In addition,the unique nanofibrous heterostructure increases the exposed active sites and promotes the electrical conductivity.Therefore,the prepared Ir-CeO_(2)-C nanofibrous catalyst delivers an excellent OER property in both alkaline and acidic solutions.Impressively,the overpotentials to reach 10 mA·cm^(−2)are only 279 and 283 mV in the alkaline and acidic electrolyte,respectively,with favorable long-term stabilities.In addition,the two-electrode overall water splitting set-ups equipped with Ir-CeO_(2)-C NFs as anode and commercial Pt/C as cathode provide a cell voltage of 1.54 and 1.53 V to drive 10 mA·cm^(−2)in the alkaline and acidic electrolyte,respectively,which are much lower than Pt/C||IrO_(2)and lots of transition metal oxides-based electrolyzers.This research presents an efficient means to design OER catalysts with superior properties in both alkaline and acidic solutions.展开更多
锂金属具有氧化还原电位低、理论比容量大等优点,是下一代高比能电池极具发展前景的负极.然而,锂枝晶生长和低可逆性严重阻碍了高比能锂金属电池的发展.受启发于生物细胞膜结构,本文采用涂布法在锂金属表面成功构筑了一种具有仿生离子...锂金属具有氧化还原电位低、理论比容量大等优点,是下一代高比能电池极具发展前景的负极.然而,锂枝晶生长和低可逆性严重阻碍了高比能锂金属电池的发展.受启发于生物细胞膜结构,本文采用涂布法在锂金属表面成功构筑了一种具有仿生离子通道的人工界面固体电解质层(CAL).该CAL中大量带负电荷的离子通道可以促进锂离子均匀、快速的输运,有利于稳定、均匀地进行锂沉积/剥离.此外,在循环过程中,CAL底部与锂金属发生原位转化反应,生成了一层富含亲锂性无机组分的过渡层,促进了锂离子的扩散并抑制了锂金属与电解液的连续副反应.因此,形成的具有双面神结构的人工界面固体电解质层(CAJL)使得锂金属负极可以在10 mA cm^(-2)的高电流密度和10 mAh cm^(-2)的高面积容量下长期稳定循环.更重要的是,基于CAJL功能化锂金属负极的锂硫软包电池实现了429.2 Wh kg^(-1)的高能量密度.展开更多
基金This work was supported by the Innovation Program for Quantum Science and Technology(2021ZD0303305 to Daiqian Xie)by the National Natural Science Foundation of China(No.22073042 and No.22122302 to Xixi Hu,No.22233003 and No.22241302 to Daiqian Xie)。
基金funded by Shenzhen Science and Technology Innovation Commission(KCXFZ20201221173207022)。
文摘Andrias davidianus(Chinese giant salamander,CGS)is the largest and oldest extant amphibian species in the world and is a source of prospective functional food in China.However,the progress of functional peptides mining was slow due to lack of reference genome and protein sequence data.In this study,we illustrated full-length transcriptome sequencing to interpret the proteome of CGS meat and obtain 10703 coding DNA sequences.By functional annotation and amino acid composition analysis,we have discovered various genes related to signal transduction,and 16 genes related to longevity.We have also found vast variety of functional peptides through protein coding sequence(CDS)analysis by comparing the data obtained with the functional peptide database.Val-Pro-Ile predicted by the CDS analysis was released from the CGS meat through enzymatic hydrolysis,suggesting that our approach is reliable.This study suggested that transcriptomic analysis can be used as a reference to guide polypeptide mining in CGS meat,thereby providing a powerful mining strategy for the bioresources with unknown genomic and proteomic sequences.
基金funded by the Ministry of Science and Technology of the People’s Republic of China,National Key Research and Development Program(2018YFC1706001)Tianjin Municipal Science and Technology Bureau,Tianjin Science and Technology Plan Project(21JCQNJC01560)+5 种基金Tianjin Education Commission scientific research project(2022KJ170)Tianjin Municipal Education commissionTianjin Graduate Research Innovation Project(Service Industry Project)(2022BKYZ046)Tianjin University of Traditional Chinese MedicineTianjin University of Traditional Chinese Medicine Graduate Research Innovation Project(Clinical Research Project YJSKC-20222002)the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Exploration and Innovation Project(YB202112).
文摘Acupuncture is an effective treatment for ischemic stroke(IS)and plays a key role in neurological rehabilitation after IS.Acupuncture can improve the clinical symptoms of various complications after IS,including motor dysfunction,swallowing disorders,speech disorders,cognitive impairment,depression,insomnia,and fatigue.However,the mechanisms underlying the effects of acupuncture in IS remain unclear.Available evidence suggests that acupuncture may exert neuroprotective effects through neuroplasticity(neurogenesis and synaptogenesis),angiogenesis,cell proliferation and apoptosis,and regulation of oxidative stress,inflammation,and immunity.Further studies should be conducted to improve the high-quality evidence-based system of acupuncture intervention for IS,by focusing on the clinical and basic research design,increasing the sample size,standardizing and quantifying the standards of acupuncture operations,using multidisciplinary techniques and methods to systematically explore the key targets of acupuncture intervention for IS,and reveal the efficacy and mechanism of acupuncture in the treatment of IS.
基金Sponsored by the National Natural Science Foundation of China(Grant No.51975396)the Natural Science Foundation of Shanxi Province(Grant No.202103021224264).
文摘The error caused by irreversible demagnetization damages the accurate velocity tracking of an in-wheel motor in a mobile robot.A current feedforward vector control system based on ESO is proposed to compensate it for the demagnetization motor.A demagnetization mathematical model is established to describe a permanent magnet synchronous motor,which took the change of permanent magnet flux linkage parameters as a factor to count the demagnetization error in velocity tracking.The uncertain disturbance estimation model of the control system is built based on ESO,which eliminates the system error by the feedforward current compensation.It is compared with the vector control method in terms of control accuracy.The simulation results show that the current feedforward vector control method based on ESO reduces the velocity tracking error greatly in conditions of motor demagnetization less than 30%.It is effective to improve the operation accuracy of the mobile robot.
文摘Colorectal cancer(CRC)represents a considerable global health challenge,ranking third in incidence and second in mortality worldwide.However,existing therapies for diseases with advanced stages often fail,thereby necessitating the search for more comprehensive treatments.Oncolytic virus,a novel anticancer approach,exhibits promising capabilities in selectively targeting and destroying tumor cells while augmenting their efficacy through genetic engineering modifications.Anticipated as a new therapeutic paradigm for CRC,this study aimed to assess the performance of oncolytic virus in clinical trials and explore their potential synergies with other therapeutic modalities,offering insights into the future direction of CRC treatment.
基金School-level innovation training project of Chongqing Institute of Technology-New Building Landscape Balcony(No.CXCY2023066)School-level project of Chongqing Institute of Technology:Research on Urban Waterfront Landscape Design Based on the Concept of River Ecological Restoration-Taking the Chongqing Institute of Technology Section of Huaxi River as an Example(No.2022xskz02)。
文摘With the acceleration of urbanization and the improvement of people’s living standards,people have increasingly higher requirements for the living environment,especially in the design of outdoor balconies.However,existing landscape balconies generally suffer from insufficient shading and rainwater drainage problems,which affects people’s living experience.In response to this problem,this article proposes a new design scheme for building landscape balconies to solve the existing problems of landscape balconies.This design plan fully considers the user’s usage needs and scenarios,improves the use value and comfort of the balcony through technical means,and achieves intelligence and functionality.
基金supported by the National Natural Science Foundation of China (Grant Nos. 42188101 and 41974181)the B-type Strategic Priority Program of the Chinese Academy of Sciences (CAS, Grant No. XDB41000000)+3 种基金the Project of Stable Support for Youth Team in Basic Research Field, CAS (Grant No. YSBR-018)the preresearch project on Civil Aerospace Technologies (Grant No. D020105) funded by China’s National Space Administrationthe International Partnership Program of CAS (Grant No. 183311KYSB20200003)The National Center for Atmospheric Research is sponsored by the National Science Foundation.
文摘In this study,we investigate the solar cycle dependence of the sunrise ionospheric zonal electric fields at the equator under geomagnetically quiet conditions.Simulations using the Thermosphere–Ionosphere–Electrodynamics General Circulation Model(TIEGCM)reveal that the equatorial eastward electric field at sunrise decreases with the increase in solar activity,independent of longitude,season,and lower atmospheric tides.The solar cycle dependence of the sunrise zonal electric field is mainly related to the zonal wind dynamo.Moreover,this solar cycle dependence of sunrise electric fields at the equator is dominated by the corresponding variation in the F-region dynamo because the response of conductivity and neutral winds near sunrise to increasing solar flux is stronger in the F-region than in the E-region,although the sunrise eastward enhancement of electric fields is mainly driven by the E-region zonal wind dynamo.Specifically,the westward gradient of low-latitude F-region neutral winds near the dawn terminator tends to produce westward electric fields in the equatorial region that are more pronounced at solar maximum,whereas the midlatitude E-region dynamo induces an eastward enhancement of sunrise electric fields at the equator that decreases slightly with increasing solar activity.This study also reveals that the reason the eastward enhancement of equatorial zonal electric fields near dawn and dusk terminators show opposite solar cycle dependence is because of their different generation mechanisms.
基金supported by the Pamela and Wayne Garrison Distinguished Chair in Cancer Research to J.C.J.C.also received support from the CPRIT awards(Grant Nos RP160667 and RP180813)NIH grants(Grant Nos P01CA193124,R01CA210929,R01CA216911,and R01CA216437)。
文摘Cancer-related diseases represent the second overall cause of death worldwide.Human papilloma virus(HPV)is an infectious agent which is mainly sexually transmitted and may lead to HPV-associated cancers in both men and women.Almost all cervical cancers are HPV-associated,however,an increasing number of head and neck cancers(HNCs),especially oropharyngeal cancer,can be linked to HPV infection.Moreover,anogenital cancers,including vaginal,vulvar,penial,and anal cancers,represent a subset of HPVrelated cancers.Whereas testing and prevention of cervical cancer have significantly improved over past decades,anogenital cancers remain more difficult to confirm.Current clinical trials including patients with HPV-related cancers focus on finding proper testing for all HPV-associated cancers as well as improve the currently applied treatments.The HPV viral oncoproteins,E6 and E7,lead to degradation of,respectively,p53 and pRb resulting in entering the S phase without G1 arrest.These high-risk HPV viral oncogenes alter numerous cellular processes,including DNA repair,angiogenesis,and/or apoptosis,which eventually result in carcinogenesis.Additionally,a comprehensive analysis of gene expression and alteration among a panel of DNA double strand breaks(DSB)repair genes in HPV-negative and HPV-positive HNC cancers reveals differences pointing to HPV-dependent modifications of DNA repair processes in these cancers.In this review,we discuss the current knowledge regarding HPV-related cancers,current screening,and treatment options as well as DNA damage response-related biological aspects of the HPV infection and clinical trials.
基金supported by the National Natural Science Foundation of China,No.61070077,61170136,61373101,81171290the Natural Science Foundation of Shanxi Province in China,No.2010011020-2,2011011015-4+3 种基金Programs for Science and Technology Social Development of Shanxi Province,No.20130313012-2Science and Technology Projects by Shanxi Provincial Ed-ucation Ministry,No.20121003Youth Fund by Taiyuan University of Technology,No.2012L014Youth Team Fund by Taiyuan University of Technology,No.2013T047
文摘Depression is closely linked to the morphology and functional abnormalities of multiple brain regions; however, its topological structure throughout the whole brain remains unclear. We col- lected resting-state functional MRI data from 36 first-onset unmedicated depression patients and 27 healthy controls. The resting-state functional connectivity was constructed using the Auto- mated Anatomical Labeling template with a partial correlation method. The metrics calculation and statistical analysis were performed using complex network theory. The results showed that both depressive patients and healthy controls presented typical small-world attributes. Compared with healthy controls, characteristic path length was significantly shorter in depressive patients, suggesting development toward randomization. Patients with depression showed apparently abnormal node attributes at key areas in cortical-striatal-pallidal-thalamic circuits. In addition, right hippocampus and right thalamus were closely linked with the severity of depression. We se- lected 270 local attributes as the classification features and their P values were regarded as criteria for statistically significant differences. An artificial neural network algorithm was applied for classification research. The results showed that brain network metrics could be used as an effec- tive feature in machine learning research, which brings about a reasonable application prospect for brain network metrics. The present study also highlighted a significant positive correlation between the importance of the attributes and the intergroup differences; that is, the more sig- nificant the differences in node attributes, the stronger their contribution to the classification. Experimental findings indicate that statistical significance is an effective quantitative indicator of the selection of brain network metrics and can assist the clinical diagnosis of depression.
基金sponsored by the National Natural Science Foundation of China,No.61070077,61170136,61373101the Natural Science Foundation of Shanxi Province,No.2011011015-4Beijing Postdoctoral Science Foundation,No.Q6002020201201
文摘Brain structure and cognitive function change in the temporal lobe, hippocampus, and prefrontal cortex of patients with mild cognitive impairment and Alzheimer's disease, and brain network-connection strength, network efficiency, and nodal attributes are abnormal. However, existing research has only analyzed the differences between these patients and normal controls. In this study, we constructed brain networks using resting-state functional MRI data that was extracted from four populations (nor- mal controls, patients with early mild cognitive impairment, patients with late mild cognitive impairment, and patients with Alzheimer's disease) using the Alzheimer's Disease Neuroimaging Initiative data set. The aim was to analyze the characteristics of resting-state functional neural networks, and to observe mild cognitive impairment at different stages before the transformation to Alzheimer's disease. Results showed that as cognitive deficits increased across the four groups, the shortest path in the rest- ing-state functional network gradually increased, while clustering coefficients gradually decreased. This evidence indicates that dementia is associated with a decline of brain network efficiency. In addi- tion, the changes in functional networks revealed the progressive deterioration of network function across brain regions from healthy elderly adults to those with mild cognitive impairment and AIz- heimer's disease. The alterations of node attributes in brain regions may reflect the cognitive functions in brain regions, and we speculate that early impairments in memory, hearing, and language function can eventually lead to diffuse brain injury and other cognitive impairments.
基金supported by National Natural Science Foundation of China(21603187,21763031,22062025)National Special Funds of China(C176220100063)Program for Excellent Young Talents of Yunnan University,Yunnan Fundamental Research Projects(202001AW070012)。
文摘Catalytic hydrogenation of furfural to furfuryl alcohol is an important upgrading process for valorization of biomass-derived furanyl platform molecules.However,selective hydrogenation of a,b-unsaturated aldehydes like furfural to the corresponding alcohols at ambient pressure remains challenging in sustainable chemistry.Till date heterogeneous Au hydrogenation catalyst has been scarcely reported for this reaction due to the low reactivity of Au for H_(2)dissociation.In this work,we showed that Au nanoparticles(loading:0.2 wt%)with a mean size of about 3 nm supported on Cu-doped Al_(2)O_(3)can efficiently hydrogenate furfural to furfuryl alcohol in liquid phase at ambient pressure.We demonstrated that doping a small amount of Cu(2 mol%)to g-Al_(2)O_(3)may modify the Lewis acidity-basicity of Al_(2)O_(3)and simultaneously induce the presence of sufficient Cu^(+) species on surface,which facilitated the hydrogen transfer from i-PrOH to furfural.Moreover,we observed an enhanced reactivity of Au toward molecular H_(2)via cooperation with the Lewis acidic-basic Cu_(2)O-Al_(2)O_(3)support.Hence,100%yield to furfuryl alcohol with a productivity of 0.98 g_(FA),h^(-1),g^(-1)_(cat.)at 120C and 0.1 MPa H_(2)can be obtained.The prepared Au/Cu-Al_(2)O_(3)catalyst was found reusable and was effective to the concentrated furfural solution,as well as several typical unsaturated aldehydes.
基金financially support by the Key-Area Research and Development Program of Guangdong Province(2020B020226008,2018b020206001)the National Science Foundation of China(NSFC31171673)。
文摘The role of gut microbiota in terms of host health is becoming increasingly important.In this study,the comparative effects of tea polyphenols(TPs)on weight loss and lipid metabolism on conventionalized mice(CVZ)and pseudo germ-free(PGF)mice(treated with antibiotics)were investigated.Our findings revealed that high fat(HF)diet considerably increased the body weight,total fat and upsurge lipid indices in CVZ mice but PGF mice were not sensitive to the effect of HF diet as CVZ mice.After the dietary administration of TP,body weight,perirenal fat and epididymal fat,liver weight,glucose(GLU)level,total chloestrol(TC level),high density lipoprotein-cholesterol(HDL-C)level significantly lowered in PGF mice as compared to CVZ mice group.However,the area of fat cells and triglyceride(TG)level were significantly increased in PGF mice.In CVZ mice,TP intervention resulted in a considerable drop in the Firmicutes/Bacteroides ratio as compared to PGF mice.The intestinal flora of PGF mice was severely reduced after antibiotic treatment,while TP administration restored intestinal diversity;the abundance of Akkermansia and Lactobacillus increased,whereas the abundance of Enterobacteriaceae and Prevotella reduced.Overall,we can assume that PGF obese mice administered with TP have less anti-obesity effects compared to obese CVZ mice.
基金financially supported by the National Natural Science Foundation of China(21975206,21901206)。
文摘Constructing heterostructures is an important approach to develop high-performance anode materials for sodium ion batteries(SIBs).The abundant phase interfaces provide numerous defects and active sites for rapid electron/ion transport.Herein,CoSe_(2)■NC@NC/MoS_(2) heterostructures are prepared through a multi-step reaction strategy,CoSe_(2) nanoparticles served as the coating shells for MoS_(2) cores are anchored in carbon frameworks.The core–shell structure effectively buffers the double volume expansion and inhibits the dissolution of MoS_(2) and CoSe_(2) in the electrolyte.AsSIBs anodes,the heterostructure delivers a high reversible capacity of 481.6 m Ah g^(-1) at 0.5 A g^(-1) after 100 cycles,superior rate capability(174.5 m Ah g^(-1) at 20.0 A g^(-1)),excellent long-term cycle performance(333.4 m Ah g^(-1) after 2000 cycles at 5.0 A g^(-1)).The DFT calculation proves that the electronic distribution of heterostructures is reconstructed with enhanced conductivity.The kinetic analysis,mechanism characterizations and full-cells tests exhibit the synergistic reaction mechanism among different components and practical application prospects.The heterostructure also shows more rapid ions diffusion kinetics than single components.
基金supported by the National Magnetic Confinement Fusion Energy R&D Program of China(2018YFE0304100,2018YFE0302100)Anhui Provincial Natural Science Foundation(1808085MA25)。
文摘Disruption prediction using a long short-term memory(LSTM)algorithm has been developed on EAST,due to its inherent advantages in time series data processing.In the present work,LSTM is used as the model and the AUC(area under receiver operation characteristic curve)is used as the evaluation index.When the model is trained on data from the plasma current flattop phase and tested on data from the same period multiple times,the highest AUC is 0.8646 and the training time is about 6900 s per epoch.For comparison,the last 1000 ms of the flattop phases are intercepted as short time sequences.When the model is trained on data from short time sequences and tested on data from the same period,the highest AUC is increased to 0.9379 and the training time is restricted to 36 s per epoch.When the best model trained on the short time sequences is applied to the flattop phase for testing,the AUC is up to 0.9189.The experiment results show that it is possible for LSTM to train the model on data from short time sequences and migrate the model to the entire flattop phase,with a shorter training time and higher AUC value.
基金NSFC,Grant/Award Numbers:22274057,21875069,21788102Guangdong Provincial Basic and Applied Basic Research Fund Regional Joint Fund Project(Youth Fund Project),Grant/Award Number:2022A1515110842Chinese Postdoctoral Science Foundation,Grant/Award Number:2022M711194。
文摘Rheumatoid arthritis(RA)is a debilitating autoimmune disease that causes chronic pain and serious complications,presenting a significant challenge to treat.Promising approaches for treating RA involve signaling pathways modulation and targeted therapy.To this end,a multifunctional nanosystem,TPC-U@HAT,has been designed for RA therapy,featuring multitargeting,dual-stimuli response,and on-demand drug release capabilities.TPC-U@HAT is composed of a probe/prodrug TPC,a JAK1 kinase inhibitor upadacitinib,and the drug carrier HAT.TPC is composed of an aggregation-induced emission(AIE)-active NIR-II chromophore TPY and an NF-κB/NLRP3 inhibitor caffeic acid phenethyl ester(CAPE),connected via boronic ester bond which serves as the reactive-oxygen-species-responsive linker.The carrier,HAT,is created by grafting bone-targeting alendronate and hydrophobic tocopheryl succinate onto hyaluronic acid chains,which can encapsulate TPC and upadacitinib to form TPC-U@HAT.Upon intravenous injection into mice,TPC-U@HAT accumulates at inflamed lesions of RA through both active and passive targeting,and the overexpressed hyaluronidase and H_(2)O_(2) therein cleave the hyaluronic acid polymer chains and boronate bonds,respectively.This generates an AIE-active chromophore for detection and therapeutic evaluation of RA via both optoacoustic imaging and NIR-II fluorescent imaging and concomitantly releases CAPE and upadacitinib to exert efficacious therapy by inhibiting NF-κB/NLRP3 and JAK-STAT pathways.
基金supported by the National Natural Science Foundation of China(grant nos.22271046,21971038,and 21975044)the Fujian Provincial Department of Science and Technology(grant no.2019L3004).
文摘Flexible-robust hydrogen-bonded organic frameworks(HOFs)are attracting increasing interest due to their excellent separation performance for important industrial gases,but the construction remains challenging.Herein,a sticked-layer strategy is first proposed to construct a flexible-robust HOF,HOFFJU-8,from a donor(D)–π–acceptor(A)molecule 4,4′,4″,4‴-(pyrrolo[3,2-b]pyrrole-1,2,4,5-tetrayl)tetrabenzonitrile(DP-4CN).HOF-FJU-8 is amicroporous three-dimensional framework composed of two kinds of DP-4CN molecules,one acting as building units for the two-dimensional layer via C≡N···H–C hydrogen bond dimers and another as the sticks to link the layers along channels through D–Aπ···πinteractions.The activated framework HOF-FJU-8a possesses flexible-robust pore characteristics,as determined by the gas adsorption and in situ gas-loaded powder X-ray diffraction.HOF-FJU-8a exhibits adaptive adsorption and stronger binding affinity to C_(2)H_(2)rather than CO_(2)due to the flexible-robust nature,which can effectively separate acetylene and carbon dioxide mixtures.
基金the Fund of Natural Science Founda-tion of Shaanxi Provincial(No.2021JQ-111)the Fund of Basic and Applied Fundamental Research of Guangdong Provincial(No.2020A1515110861).
文摘The design and fabrication of electromagnetic interference shielding films with a novel structure to eliminate undesirable electromagnetic pollution is an important research direction.However,it is still a challenge to combine and organize nanofillers in different dimensions into the structured network in polymer-based electromagnetic interference(EMI)shielding composites.In this work,a sandwich struc-ture polyimide(PI)composite film with alternative 2D-MXene network and 1D-Silver nanowires(Ag NWs)network was prepared through the“electrospinning-immersion-hot pressing”method.With the increase of Ag NWs content,the EMI shielding effectiveness(SE)gradually increases while maintaining good flexibility and mechanical robustness.The EMI SE and the tensile strength of 150μm thick sand-wich composite film can reach up to 79.54 dB and 39.82 MPa,respectively.The prepared flexible and robust PI composite film with a sandwich structure has high EMI SE with less metal content,which can provide guidelines for the development of high-performance EMI polymeric films with potentials in wearable devices and equipment.
基金the National Natural Science Foundation of China(Nos.51973079 and 21673093)the Natural Science Foundation of Fujian Province(No.2020J01147)+1 种基金Research Foundation of Academy of Carbon Neutrality of Fujian Normal University(No.TZH2022-05)Minjiang Scholar and Startup Fund for High-level Talent at Fujian Normal University.
文摘Anodic oxygen evolution reaction(OER)is essential to participate in diverse renewable energy conversion and storage processes,while most OER electrocatalysts present satisfactory catalytic performance in only alkaline or acidic medium,limiting their practical applications in many aspects.Herein,we have designed and prepared Ir-CeO_(2)-C nanofibers(NFs)via an electrospinning and a relatively low-temperature calcination strategy for OER application in both alkaline and acidic conditions.Density functional theory(DFT)simulations demonstrate the high catalytic active sites of Ir atoms for OER,that the formation of Ir–O bonds at the interface between Ir and CeO_(2)can modulate the electron density of the relevant Ir atoms to promote the OER activity.In addition,the unique nanofibrous heterostructure increases the exposed active sites and promotes the electrical conductivity.Therefore,the prepared Ir-CeO_(2)-C nanofibrous catalyst delivers an excellent OER property in both alkaline and acidic solutions.Impressively,the overpotentials to reach 10 mA·cm^(−2)are only 279 and 283 mV in the alkaline and acidic electrolyte,respectively,with favorable long-term stabilities.In addition,the two-electrode overall water splitting set-ups equipped with Ir-CeO_(2)-C NFs as anode and commercial Pt/C as cathode provide a cell voltage of 1.54 and 1.53 V to drive 10 mA·cm^(−2)in the alkaline and acidic electrolyte,respectively,which are much lower than Pt/C||IrO_(2)and lots of transition metal oxides-based electrolyzers.This research presents an efficient means to design OER catalysts with superior properties in both alkaline and acidic solutions.
基金financially supported by the Research Grants Council of the Hong Kong Special Administrative Region,China(T23-601/17-R)supported by the Fundamental Research Funds for the Central Universities(D5000220443)。
文摘锂金属具有氧化还原电位低、理论比容量大等优点,是下一代高比能电池极具发展前景的负极.然而,锂枝晶生长和低可逆性严重阻碍了高比能锂金属电池的发展.受启发于生物细胞膜结构,本文采用涂布法在锂金属表面成功构筑了一种具有仿生离子通道的人工界面固体电解质层(CAL).该CAL中大量带负电荷的离子通道可以促进锂离子均匀、快速的输运,有利于稳定、均匀地进行锂沉积/剥离.此外,在循环过程中,CAL底部与锂金属发生原位转化反应,生成了一层富含亲锂性无机组分的过渡层,促进了锂离子的扩散并抑制了锂金属与电解液的连续副反应.因此,形成的具有双面神结构的人工界面固体电解质层(CAJL)使得锂金属负极可以在10 mA cm^(-2)的高电流密度和10 mAh cm^(-2)的高面积容量下长期稳定循环.更重要的是,基于CAJL功能化锂金属负极的锂硫软包电池实现了429.2 Wh kg^(-1)的高能量密度.