1Introduction The condenser plays a vital role in the operation of a thermal power generation unit.Its primary function is to remove the heat from the steam that is exhausted from the steam turbine,thereby condensing ...1Introduction The condenser plays a vital role in the operation of a thermal power generation unit.Its primary function is to remove the heat from the steam that is exhausted from the steam turbine,thereby condensing the steam into water.Additionally,it establishes and maintains a specific degree of vacuum at the exhaust port of the steam turbine,facilitating efficient operation of the turbine(Keshvarparast et al.,2020).The vacuum degree of the condenser is affected by physical factors such as steam-side resistance and heat-transfer efficiency.展开更多
Chiral drug naftopidil(NAF), a specific α1D-adrenoceptor(AR) antagonist for the treatment of benign prostatic hyperplasia, was used in racemic form for several decades. Our recent work declared that NAF enantiomers s...Chiral drug naftopidil(NAF), a specific α1D-adrenoceptor(AR) antagonist for the treatment of benign prostatic hyperplasia, was used in racemic form for several decades. Our recent work declared that NAF enantiomers showed the same antagonistic effects on the α1D-AR, but the binding mechanism of these two stereochemical NAF isomers to the α1D receptor remained unclear. Herein, we reported the crystallographic structures of optically pure NAF stereoisomers for the first time and unambiguously determined their absolute configurations. The crystal data of R and S enantiomers matched satisfactorily the pharmacophore model for α1D-selective antagonists. Based on the constructed α1D homology model,molecular docking studies shed light on the molecular mechanism of NAF enantiomers binding to α1D-AR. The results indicated that NAF enantiomers exhibited the very similar binding poses and occupied the same binding pocket.展开更多
Truncated L1 regularization proposed by Fan in[5],is an approximation to the L0 regularization in high-dimensional sparse models.In this work,we prove the non-asymptotic error bound for the global optimal solution to ...Truncated L1 regularization proposed by Fan in[5],is an approximation to the L0 regularization in high-dimensional sparse models.In this work,we prove the non-asymptotic error bound for the global optimal solution to the truncated L1 regularized linear regression problem and study the support recovery property.Moreover,a primal dual active set algorithm(PDAS)for variable estimation and selection is proposed.Coupled with continuation by a warm-start strategy leads to a primal dual active set with continuation algorithm(PDASC).Data-driven parameter selection rules such as cross validation,BIC or voting method can be applied to select a proper regularization parameter.The application of the proposed method is demonstrated by applying it to simulation data and a breast cancer gene expression data set(bcTCGA).展开更多
基金supported by the National Natural Science Foundation of China(No.51806192)the Fundamental Research Funds for the Central Universities of China(No.2022ZFJH004).
文摘1Introduction The condenser plays a vital role in the operation of a thermal power generation unit.Its primary function is to remove the heat from the steam that is exhausted from the steam turbine,thereby condensing the steam into water.Additionally,it establishes and maintains a specific degree of vacuum at the exhaust port of the steam turbine,facilitating efficient operation of the turbine(Keshvarparast et al.,2020).The vacuum degree of the condenser is affected by physical factors such as steam-side resistance and heat-transfer efficiency.
基金supported by grants from the National Science Foundation of Guangdong Province (No. S2013040014088)the Postdoctoral Science Foundation of Guangzhou City (Q188)partially supported by the Guangdong Major Scientific and Technological Special Project for New Drug Development (2013A022100029)
文摘Chiral drug naftopidil(NAF), a specific α1D-adrenoceptor(AR) antagonist for the treatment of benign prostatic hyperplasia, was used in racemic form for several decades. Our recent work declared that NAF enantiomers showed the same antagonistic effects on the α1D-AR, but the binding mechanism of these two stereochemical NAF isomers to the α1D receptor remained unclear. Herein, we reported the crystallographic structures of optically pure NAF stereoisomers for the first time and unambiguously determined their absolute configurations. The crystal data of R and S enantiomers matched satisfactorily the pharmacophore model for α1D-selective antagonists. Based on the constructed α1D homology model,molecular docking studies shed light on the molecular mechanism of NAF enantiomers binding to α1D-AR. The results indicated that NAF enantiomers exhibited the very similar binding poses and occupied the same binding pocket.
文摘Truncated L1 regularization proposed by Fan in[5],is an approximation to the L0 regularization in high-dimensional sparse models.In this work,we prove the non-asymptotic error bound for the global optimal solution to the truncated L1 regularized linear regression problem and study the support recovery property.Moreover,a primal dual active set algorithm(PDAS)for variable estimation and selection is proposed.Coupled with continuation by a warm-start strategy leads to a primal dual active set with continuation algorithm(PDASC).Data-driven parameter selection rules such as cross validation,BIC or voting method can be applied to select a proper regularization parameter.The application of the proposed method is demonstrated by applying it to simulation data and a breast cancer gene expression data set(bcTCGA).
