地黄饮子治疗痴呆效果研究的Meta分析

目的:系统评价地黄饮子加减及联合常规西药治疗痴呆的有效性。方法:计算机检索中国知网、中国生物医学文献数据库、万方数据库、维普数据库、PubMed、Web of science、Embase数据库中地黄饮子加减及联合常规西药治疗痴呆的随机对照试验,检索时间为各数据库建库至2023年9月。筛选符合纳入标准的文献进行质量评价,提取相应资料,采用RevMan5.3软件进行Meta分析。结果:共纳入文献21篇,1647例患者。Meta分析结果显示,治疗组的临床疗效高于对照组[OR=4.22,95%CI(3.22,5.52),P<0.00001],治疗组改善痴呆的MMSE评分高于对照组[MD=3.88,95%CI(1.98,5.77),P<0.0001],治疗组改善痴呆的HDS评分高于对照组[MD=3.86,95%CI(1.85,5.88),P<0.01],治疗组改善痴呆的ADL评分低于对照组[MD=-2.79,95%CI(-4.56,-1.02),P<0.01]。治疗组痴呆的不良反应发生率未明显低于对照组[OR=0.50,95%CI(0.25,0.99),P=0.05>0.01]。结论:地黄饮子加减及联合常规西药治疗痴呆的总有效率高于单纯常规西药治疗,且可改善简易精神状态检查量表(mini-mental state examination,MMSE)、长谷川痴呆量表(hastgawa dementia scale,HDS)和日常生活能力量表(activity of daily living scale,ADL)评分。本研究存在一定的局限性,仍需多中心、大样本、高质量的研究补充论证。

Estimated Human Papillomavirus Vaccine Coverage Among Females 9-45 Years of Age — China, 2017-2022

Summary What is already known on this topic?There is a lack of comprehensive data on the coverage of the human papillomavirus(HPV)vaccine in China.The limited published literature hampers our ability to accurately assess the current situation.What is added by this report?

Enhanced ionic diffusion interface in hierarchical metal-organic framework@layered double hydroxide for high-performance hybrid supercapacitors

Layered double hydroxides(LDHs)with abundant accessible active sites are promising electrode materials for hybrid supercapacitor(HSC)due to their ultrahigh theoretical capacitances.However,the structural agglomeration of LDH leads to poor rate capability and durability.Herein,we construct a diffusion-controlled interface in hierarchical architecture of metal-organic framework(MOF)HKUST-1@cobalt-nickel LDH(denoted as HKUST-1@CoNiLDH)through an in situ etching/electro-deposition strategy.The rapid charge transfer and ionic diffusion in HKUST-1@CoNiLDH deliver a remarkable specific capacity of 297.23 mAh·g^(−1) at 1 A·g^(−1),superior to mostly reported LDH-based electrodes.More importantly,the as-prepared HKUST-1@CoNiLDH//activated carbon HSC exhibit a high energy density of 39.8 Wh·kg^(−1) at a power density of 799.9 W·kg^(−1) with an outstanding capacitance retention of 90%after 5,000 charge–discharge cycles.The in-depth understanding of the ionic diffusion among the MOF/LDH interfaces will greatly promote the further development of designing and synthesizing high performance energy conversion and storage devices.

Cenozoic magmatic activity and oblique uplifting of the Ailao Mountain: Evidence from a short-period dense seismic array

Geological studies show that the southern part of Ailaoshan-Red River shear zone(ALSRRSZ)has experienced complex metallogenic processes and multi-stage non-uniform uplifting,called oblique uplifting since the Cenozoic.To detect the deep structure and geodynamic background beneath Daping,Chang’an and other gold and polymetallic deposits in this area,we carried out a high-density short-period seismic array survey in southern Yunnan province.The array used is approximately240 km long with an interval of 500 m between two adjacent stations.Based on the data collected by the array,we used H-κstacking and common conversion point(CCP)methods of receiver functions to reveal the fine crustal structure beneath this array,which was located from Lvchun(western end)to the east and ended in Maguan.The three main conclusions are as follows.(1)The average crustal thickness is approximately 37 km and the Vp/Vsratio is 1.75.However,the thickness and Vp/Vsratio of the Ailao Mountain are rather greater or higher than those of the western Lanping-Simao Basin and eastern South-China block.These results may indicate that the crust is rich in ferromagnesian minerals or has a thermal fluid anomaly after orogenic movement.(2)There are two obvious inclined interfaces beneath the Ailao Mountain in the mid-upper crust,which suggests that strong deformation occurred there during the orogenic period.Some evidences,such as the weak converted-wave Pms phase from the Moho,low P-wave velocities of the upper mantle,high surface heat flow values,and generally developed hot springs,indicate that a strong crust-mantle interaction exists in the southern segments of the Ailaoshan-Red River shear zone.These interactions include a diapir of mantle-sourced magma(stronger in the east than that in the west),lateral collision from the Indian Plate,and the differential uplift caused by the strike-slip movement of the Red River Fault.All of above deep processes led to the Cenozoic oblique uplifting of Ailao Mountain.(3)By combining the location of the deposits on the surface,characteristics of the average crustal Vp/Vsratio,hypocenters of the small earthquakes along the research profile,Moho shape,and horizontal variations of the Pms phase amplitudes,we speculate that the Ailaoshan Fault was the upgoing conduit for metallogenic magma and played a significant role in the Cenozoic development of the multiform metal deposits around the Ailao Mountain area.

Polyoxometalate-Incorporated Host-Guest Framework Derived Layered Double Hydroxide Composites for High-Performance Hybrid Supercapacitor

Metal organic frameworks have been employed as high-performance layered double hydroxide(LDH)composite supercapacitor electrode materials but have shown unsatisfactory redox ability and stability.Herein,a host-guest CuMo-based polyoxomet-alate-based metal organic framework(POMOF)with copious electrochemically active sites and strong electrochemical redox activi-ties has been effectively coupled with POM-incorporated CoNi-LDH to develop a nanocomposite(NENU-5@CoNi-LDH)by a simple solvothermal method.The designed electrode shows a high specific capacity of 333.61 mAh·g^(-1) at 1 A·g^(-1).In addition,the novel hy-brid symmetric supercapacitor NENU-5@CoNi-LDH/active carbon(AC)demonstrated a high energy density of 80.8 Wh·kg^(-1) at a power density of 750.7 W·kg^(-1).Interestingly,the nanocomposite of NENU-5@CoNi-LDH exhibits an outstanding capacitance reten-tion of 79%after 5000 charge-discharge cycles at 10 A·g^(-1).This work provides a new strategy and will be the backbone for future energy storage research.