Progress in medicine such as the use of anti-infective drugs and development of the advanced life support equipment has greatly improved the survival rate of patients with sepsis.However,the incidence of sepsis-relate...Progress in medicine such as the use of anti-infective drugs and development of the advanced life support equipment has greatly improved the survival rate of patients with sepsis.However,the incidence of sepsis-relateddiseases is increasing.These include severe neurologic and psychologic disorders,cognitive decline,anxiety,depression,and post-traumatic stress disorder.Cerebral dysfunction occurs via multiple interacting mechanisms,with different causative pathogens having distinct effects.Because sepsis-related diseases place a substantial burden on patients and their families,it is important to elucidate the underlying pathophysiologic mechanisms todevelop effective treatments.展开更多
The apoptosis repressor with caspase recruitment domain(ARC)plays a critical role in extrinsic apoptosis initiation via death receptor ligands,physiological stress,infection response in a tissue-dependent manner,endop...The apoptosis repressor with caspase recruitment domain(ARC)plays a critical role in extrinsic apoptosis initiation via death receptor ligands,physiological stress,infection response in a tissue-dependent manner,endoplasmic reticulum(ER)stress,genotoxic drugs,ionizing radiation,oxidative stress,and hypoxia.Recent studies have suggested that regulating apoptosis-related pathways can improve outcomes for patients with neurological diseases,such as hemorrhagic stroke.ARC expression is significantly correlated with acute cerebral hemorrhage.However,the mechanism by which it mediates the anti-apoptosis pathway remains poorly known.Here,we discuss the function of ARC in hemorrhagic stroke and argue that it could serve as an effective target for the treatment of hemorrhagic stroke.展开更多
基金This work was supported by Shanghai Hospital Development Center(grant number:SHDC2020CR3021A)the National Natural Science Foundation of China(grant number:82,072,788),both to Ye Gong.
文摘Progress in medicine such as the use of anti-infective drugs and development of the advanced life support equipment has greatly improved the survival rate of patients with sepsis.However,the incidence of sepsis-relateddiseases is increasing.These include severe neurologic and psychologic disorders,cognitive decline,anxiety,depression,and post-traumatic stress disorder.Cerebral dysfunction occurs via multiple interacting mechanisms,with different causative pathogens having distinct effects.Because sepsis-related diseases place a substantial burden on patients and their families,it is important to elucidate the underlying pathophysiologic mechanisms todevelop effective treatments.
基金supported by the Shanghai Hospital Development Center(grant number:SHDC2020CR3021A,to YG)the National Natural Science Foundation of China(grant number:82072788,to YG).
文摘The apoptosis repressor with caspase recruitment domain(ARC)plays a critical role in extrinsic apoptosis initiation via death receptor ligands,physiological stress,infection response in a tissue-dependent manner,endoplasmic reticulum(ER)stress,genotoxic drugs,ionizing radiation,oxidative stress,and hypoxia.Recent studies have suggested that regulating apoptosis-related pathways can improve outcomes for patients with neurological diseases,such as hemorrhagic stroke.ARC expression is significantly correlated with acute cerebral hemorrhage.However,the mechanism by which it mediates the anti-apoptosis pathway remains poorly known.Here,we discuss the function of ARC in hemorrhagic stroke and argue that it could serve as an effective target for the treatment of hemorrhagic stroke.
