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Fast Blood Oxygenation through Hemocompatible Asymmetric Polymer of Intrinsic Microporosity Membranes
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作者 Xinxi huang junping huang +1 位作者 Pengcheng Su Wanbin Li 《Research》 SCIE EI CSCD 2024年第1期261-270,共10页
Membrane technology has attracted considerable attention for chemical and medical applications,among others.Artificial organs play important roles in medical science.A membrane oxygenator,also known as artificial lung... Membrane technology has attracted considerable attention for chemical and medical applications,among others.Artificial organs play important roles in medical science.A membrane oxygenator,also known as artificial lung,can replenish O_(2) and remove CO_(2) of blood to maintain the metabolism of patients with cardiopulmonary failure.However,the membrane,a key component,is subjected to inferior gas transport property,leakage propensity,and insufficient hemocompatibility.In this study,we report efficient blood oxygenation by using an asymmetric nanoporous membrane that is fabricated using the classic nonsolvent-induced phase separation method for polymer of intrinsic microporosity-1.The intrinsic superhydrophobic nanopores and asymmetric configuration endow the membrane with water impermeability and gas ultrapermeability,up to 3,500 and 1,100 gas permeation units for CO_(2) and O_(2),respectively.Moreover,the rational hydrophobic–hydrophilic nature,electronegativity,and smoothness of the surface enable the substantially restricted protein adsorption,platelet adhesion and activation,hemolysis,and thrombosis for the membrane.Importantly,during blood oxygenation,the asymmetric nanoporous membrane shows no thrombus formation and plasma leakage and exhibits fast O_(2) and CO_(2) transport processes with exchange rates of 20 to 60 and 100 to 350 ml m^(−2) min^(−1),respectively,which are 2 to 6 times higher than those of conventional membranes.The concepts reported here offer an alternative route to fabricate high-performance membranes and expand the possibilities of nanoporous materials for membrane-based artificial organs. 展开更多
关键词 POROSITY ASYMMETRIC OXYGEN
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模拟单眼视对视觉拥挤效应的影响 被引量:2
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作者 卓佐跑 姜珺 +3 位作者 黄俊萍 陈浙一 苏彬彬 张斌 《中华眼视光学与视觉科学杂志》 CAS CSCD 2019年第3期205-210,共6页
目的:建立单眼视的模拟方法及周边视觉拥挤效应的测量方法,并利用该方法评估模拟单眼视下的周边视觉拥挤效应是否较正常情况更严重。方法:实验研究。于2015年3-11月期间选取温州医科大学眼视光学院在校健康学生和教师20例。正常对照时,... 目的:建立单眼视的模拟方法及周边视觉拥挤效应的测量方法,并利用该方法评估模拟单眼视下的周边视觉拥挤效应是否较正常情况更严重。方法:实验研究。于2015年3-11月期间选取温州医科大学眼视光学院在校健康学生和教师20例。正常对照时,双眼均给予清晰的视标(模糊度数为0D);模拟单眼视时,左眼给予清晰的视标,右眼给予模糊的视标(模糊度数分别为0.75、1.50、2.50、3.50D,顺序随机)。视觉拥挤效应的目标视标的偏心度(Ecc)为2.5°、5.0°、7.5°(顺序随机),阈值测量方法为心理物理学的阶梯法。通过比较模拟单眼视状态与正常对照状态的视觉拥挤效应的特征和差异,评估模拟单眼视对视觉拥挤效应的影响。不同模糊度数及不同Ecc时视觉拥挤效应的比较采用双因素重复测量方差分析,组间两两比较采用Bonferroni矫正过的t检验。结果:视觉拥挤效应显著依赖于模糊度数(F=13.37,P<0.001)和Ecc(F=296.90,P<0.001)。模糊度数与Ecc的交互作用显著(F=4.03,P<0.001)。当Ecc分别为7.5°、5.0°时,不同模糊度数下测得的视觉拥挤效应差异均有统计学意义(F=8.59,P<0.001;F=3.74,P=0.01),模糊度数越大,视觉拥挤效应越重。当Ecc为2.5°时,不同模糊度数下测得的视觉拥挤效应差异均无统计学意义(F=1.13,P=0.34)。结论:相比于正常对照情况,模拟单眼视下的视觉拥挤效应加重,并且与模糊眼的模糊度数及目标视标的Ecc相关。 展开更多
关键词 单眼视 周边视功能 视觉拥挤效应 双眼竞争
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