Lung cancer is the leading cause of cancer-related deaths worldwide.Tobacco smoking and air pollution are believed to be responsible for more than 90%of lung cancers.Respiratory pathogens are also known to be associat...Lung cancer is the leading cause of cancer-related deaths worldwide.Tobacco smoking and air pollution are believed to be responsible for more than 90%of lung cancers.Respiratory pathogens are also known to be associated with the initiation and development of lung cancer.Despite the fact that the bacterial biomass in the lungs is lower than that in the intestinal tract,emerging evidence indicates that the lung is colonized by a diverse array of microbes.However,there is limited knowledge regarding the role of dysbiosis of the lung microbiota in the progression of lung cancer.In this review,we summarize the current information about the relationship between the microbiome and lung cancer.The objective is to provide an overview of the core composition of the microbiota in lung cancer as well as the role of specific dysbiosis of the lung microbiota in the progression of lung cancer and treatment of the disease.展开更多
Monodisperse hybrid Janus nanofibers with the structure that one Au nanoparticle(AuNP)is connected to one end of a polymeric nanofiber were prepared by the self-assembly between polymeric micelles and the tadpole-like...Monodisperse hybrid Janus nanofibers with the structure that one Au nanoparticle(AuNP)is connected to one end of a polymeric nanofiber were prepared by the self-assembly between polymeric micelles and the tadpole-like conjugates resulting from one-to-one complexation of long DNA chains with AuNPs.展开更多
基金This work was supported by the National Natural Science Foun-dation of China(Nos.81773147,81972198,and 81472695)the Key Research and Development Program of Hunan(No.2019SK2253)+1 种基金the Strategic Priority Research Program of Central South University(No.ZLXD2017004)the Natural Science Foundation,Changsha(No.kq2208299).
文摘Lung cancer is the leading cause of cancer-related deaths worldwide.Tobacco smoking and air pollution are believed to be responsible for more than 90%of lung cancers.Respiratory pathogens are also known to be associated with the initiation and development of lung cancer.Despite the fact that the bacterial biomass in the lungs is lower than that in the intestinal tract,emerging evidence indicates that the lung is colonized by a diverse array of microbes.However,there is limited knowledge regarding the role of dysbiosis of the lung microbiota in the progression of lung cancer.In this review,we summarize the current information about the relationship between the microbiome and lung cancer.The objective is to provide an overview of the core composition of the microbiota in lung cancer as well as the role of specific dysbiosis of the lung microbiota in the progression of lung cancer and treatment of the disease.
基金the financial support of National Natural Science Foundation of China(No.21334001)the Ministry of Science and Technology of China(No.2011CB932503).
文摘Monodisperse hybrid Janus nanofibers with the structure that one Au nanoparticle(AuNP)is connected to one end of a polymeric nanofiber were prepared by the self-assembly between polymeric micelles and the tadpole-like conjugates resulting from one-to-one complexation of long DNA chains with AuNPs.
