Nature provides diverse models for manufacturing complex and hierarchical materials by controlling molecular assembly at scales ranging from sub-nano to macroscale. However, developing artificial strategies for manufa...Nature provides diverse models for manufacturing complex and hierarchical materials by controlling molecular assembly at scales ranging from sub-nano to macroscale. However, developing artificial strategies for manufacturing hierarchical materials with comparable machining capabilities to nature is extremely challenging. Here, a templated freezing assembly strategy is reported, enabling simultaneously regulating molecular assembly spatiotemporally to obtain hierarchical materials with structure control from sub-nano to macroscale. In this way, unique centimeter-scale freestanding nanofilms are assembled from diverse molecules, e.g., proteins and conjugated polymers. A generated silk fibroin(SF) nanofilm presents a tunable β-sheet fraction from 5% to 47%, fiber width from 30 to 3,000 nm, and micro-textures with desired shapes. Such a strategy will lay the foundation for customizing hierarchical functional materials from single or multi-component molecules, e.g., desired bioscaffolds with controlled cell adhesion.展开更多
基金supported by the National Key Research and Development Program of China(2020YFE0100300,2018YFA0208502)the National Natural Science Foundation of China(51925307,21733010,32001083,22105210)+2 种基金the Key Research Program of Frontier Sciences,Chinese Academy of Sciences(ZDBS-LY-SLH031)the Beijing National Laboratory for Molecular Sciences(BNLMS-CXXM2020BMS20025).the Strategic Priority Research Program,Chinese Academy of Sciences(XDB28000000)the National Natural Science Foundation of China(12174388).
文摘Nature provides diverse models for manufacturing complex and hierarchical materials by controlling molecular assembly at scales ranging from sub-nano to macroscale. However, developing artificial strategies for manufacturing hierarchical materials with comparable machining capabilities to nature is extremely challenging. Here, a templated freezing assembly strategy is reported, enabling simultaneously regulating molecular assembly spatiotemporally to obtain hierarchical materials with structure control from sub-nano to macroscale. In this way, unique centimeter-scale freestanding nanofilms are assembled from diverse molecules, e.g., proteins and conjugated polymers. A generated silk fibroin(SF) nanofilm presents a tunable β-sheet fraction from 5% to 47%, fiber width from 30 to 3,000 nm, and micro-textures with desired shapes. Such a strategy will lay the foundation for customizing hierarchical functional materials from single or multi-component molecules, e.g., desired bioscaffolds with controlled cell adhesion.
