Objective： The aim of this prospective, single-arm phase II trial was to confirm the safety and efficacy of neoadjuvant chemotherapy（NAC） using oxaliplatin plus capecitabine（Cap OX） for patients with operable loc...Objective： The aim of this prospective, single-arm phase II trial was to confirm the safety and efficacy of neoadjuvant chemotherapy（NAC） using oxaliplatin plus capecitabine（Cap OX） for patients with operable locally advanced colon cancer（CC）.Methods： Patients with computed tomography-defined T4 or lymph node-positive CCs were enrolled. After radiological staging, patients were treated with at least 2 cycles of NAC consisting of 130 mg/m2 oxaliplatin on d 1,plus 1,000 mg/m2 capecitabine twice daily for 14 d every 3 weeks, followed by surgery, and then with the rest cycles of adjuvant chemotherapy. Radiological response was evaluated after 2 cycles of NAC. Tumor response, treatment toxicity, and surgical complications were recorded. The pathological response to therapy was evaluated according to the tumor regression grade（TRG） score. The primary endpoint was pathologic tumor response. This trial is registered in Clinical Trials.gov（No： NCT02415829）.Results： Forty-seven patients were enrolled in the study. Forty-two patients completed the planned treatments.The total radiological response rate was 68%（32/47）, including complete and partial response rates of 2%（1/47）and 66%（31/47）, respectively. Stable disease was observed in 32%（15/47） and progressive disease was observed in none. Complete pathologic response, major regression, and at least moderate regression were achieved in 1（2%）, 2（4%）, and 29（62%） patients, respectively. Four patients developed grade 3 treatment toxicities. One patient with wound infection occurred after operation（1/47, 2%）. There was no treatment-related death.Conclusions： Our results suggest that NAC with Cap OX is an effective and safe treatment option for patients with locally advanced CCs.展开更多
The construction of megaprojects has always resulted in extensive and long-term impacts on the society.However,the performance of megaproject management is poor,and improving it remains an urgent and necessary issue.A...The construction of megaprojects has always resulted in extensive and long-term impacts on the society.However,the performance of megaproject management is poor,and improving it remains an urgent and necessary issue.Although many studies on megaproject success have been conducted,existing studies on the driving factors of successful megaproject construction are rather limited.Therefore,this study aims to systematically explore the key factors that can lead to successful megaproject construction management based on three cases:The Beijing-Shanghai High-Speed Railway,the Three Gorges Dam,and the Hong Kong-Zhuhai-Macao Bridge.Mixed research methods,such as literature review,case studies,and expert interviews,were used in this study.Consequently,11 driving factors,namely,government support,public support,accumulation and application of technology and experience,development and innovation of technology,innovation and application of management system,organizational mode and structure,top management support,project culture,megaproject citizenship behavior,corporate reputation,and fulfillment of social responsibilities,were identified and grouped into five categories,namely,project environment,construction capabilities,organization,positive culture and behavior,and requirements for sustainable development.The contributions of this study lie in two aspects.First,the driving factors of successful megaproject construction are identified to deepen the understanding of industrial practitioners,assist them in focusing on key factors,and aid them in effectively managing megaprojects.Second,researchers could use the identified driving factors in conducting further empirical studies and apply them in future projects to enhance their chances of success.展开更多
Cell typing is an important step in the single-cell RNA sequencing(scRNA-seq)analysis.Although some cell marker databases and cell typing tools have been proposed,limited roles are in prostate cell typing.Through lite...Cell typing is an important step in the single-cell RNA sequencing(scRNA-seq)analysis.Although some cell marker databases and cell typing tools have been proposed,limited roles are in prostate cell typing.Through literature review,we found prostate cell typing relied much on researchers'knowledge and experience,thus different markers were used to label the same cell type,leading to the divergences between studies,emphasizing the importance of a sound epistemological foundation for prostate cell typing in single-cell data.展开更多
基金supported by grants from the National Natural Science Foundation of China (Grant No. 81472620)Shanghai Science and Technology Planning Fund (No. 13140902100)+1 种基金Shanghai Combination Study Project for Major Diseases (No. 2014ZYJB0101)Shanghai Health and Family Planning Commission (No. JGY1404)
文摘Objective： The aim of this prospective, single-arm phase II trial was to confirm the safety and efficacy of neoadjuvant chemotherapy（NAC） using oxaliplatin plus capecitabine（Cap OX） for patients with operable locally advanced colon cancer（CC）.Methods： Patients with computed tomography-defined T4 or lymph node-positive CCs were enrolled. After radiological staging, patients were treated with at least 2 cycles of NAC consisting of 130 mg/m2 oxaliplatin on d 1,plus 1,000 mg/m2 capecitabine twice daily for 14 d every 3 weeks, followed by surgery, and then with the rest cycles of adjuvant chemotherapy. Radiological response was evaluated after 2 cycles of NAC. Tumor response, treatment toxicity, and surgical complications were recorded. The pathological response to therapy was evaluated according to the tumor regression grade（TRG） score. The primary endpoint was pathologic tumor response. This trial is registered in Clinical Trials.gov（No： NCT02415829）.Results： Forty-seven patients were enrolled in the study. Forty-two patients completed the planned treatments.The total radiological response rate was 68%（32/47）, including complete and partial response rates of 2%（1/47）and 66%（31/47）, respectively. Stable disease was observed in 32%（15/47） and progressive disease was observed in none. Complete pathologic response, major regression, and at least moderate regression were achieved in 1（2%）, 2（4%）, and 29（62%） patients, respectively. Four patients developed grade 3 treatment toxicities. One patient with wound infection occurred after operation（1/47, 2%）. There was no treatment-related death.Conclusions： Our results suggest that NAC with Cap OX is an effective and safe treatment option for patients with locally advanced CCs.
基金This study was funded by the National Natural Science Foundation of China(Grant Nos.71971161 and 71390523).
文摘The construction of megaprojects has always resulted in extensive and long-term impacts on the society.However,the performance of megaproject management is poor,and improving it remains an urgent and necessary issue.Although many studies on megaproject success have been conducted,existing studies on the driving factors of successful megaproject construction are rather limited.Therefore,this study aims to systematically explore the key factors that can lead to successful megaproject construction management based on three cases:The Beijing-Shanghai High-Speed Railway,the Three Gorges Dam,and the Hong Kong-Zhuhai-Macao Bridge.Mixed research methods,such as literature review,case studies,and expert interviews,were used in this study.Consequently,11 driving factors,namely,government support,public support,accumulation and application of technology and experience,development and innovation of technology,innovation and application of management system,organizational mode and structure,top management support,project culture,megaproject citizenship behavior,corporate reputation,and fulfillment of social responsibilities,were identified and grouped into five categories,namely,project environment,construction capabilities,organization,positive culture and behavior,and requirements for sustainable development.The contributions of this study lie in two aspects.First,the driving factors of successful megaproject construction are identified to deepen the understanding of industrial practitioners,assist them in focusing on key factors,and aid them in effectively managing megaprojects.Second,researchers could use the identified driving factors in conducting further empirical studies and apply them in future projects to enhance their chances of success.
基金supported by the National Natural Science Foundation of China,China (No.62101319,82170788)the Medical Discipline Construction Project of the Health System of Pudong New Area (China) (No.PYWgf2021-06).
文摘Cell typing is an important step in the single-cell RNA sequencing(scRNA-seq)analysis.Although some cell marker databases and cell typing tools have been proposed,limited roles are in prostate cell typing.Through literature review,we found prostate cell typing relied much on researchers'knowledge and experience,thus different markers were used to label the same cell type,leading to the divergences between studies,emphasizing the importance of a sound epistemological foundation for prostate cell typing in single-cell data.
