Relationship of endothelial nitric oxide synthase gene polymorphism with blood pressure,lipid profile and blood glucose level

To study the relationship of the polymorphism of endothelial nitric oxide synthase(eNOS)gene and blood pressure,lipid profiles and blood glucose level.By using PCR-RFLP,the eNOS Glu298Asp gene polymorphism was detected in 184 patients with essential hypertension and 196 matched healthy individuals with normal blood pressure.Taking into account eNOS Glu298Asp poly-morphisms,the relationship of blood pressure with trigly-cerides(TG),total cholesterol(TC),high density lipoprotein(HDL),low density lipoprotein(LDL)and blood glucose level was analyzed.The distribution of eNOS Glu298Asp polymorphism had no significant differ-ence between different blood pressure groups and gender groups,but there was a significant difference between dif-ferent age groups,diastolic blood pressure groups or BMI groups(P<0.05).Asp/Asp genotype significantly increased the risk of hypertension in individuals with serum TC above 5.4 mmol/L(P=0.03,OR=52.65).eNOS Glu298Asp polymorphism and serum lipid could synergis-tically modulate the blood pressure.eNOS Asp/Asp geno-type could significantly increase the risk of hypertension in individuals with serum TC over 5.4 mmol/L.eNOS Glu298Asp in combination with serum TC could be used to predict the risk of hypertension.

A review of bipolar magnetic semiconductors from theoretical aspects

Spintronics,which employs electrons'spin degree of freedom in data storage and transmision,acts as a promising candidate for next-generation information technology owing to its improved processing speed and reduced power consumption.To seek and design materials with highly spin polarized carriers and find an efficient way to control the spin polarization direction of carriers are critical and urgent to spintronics applications.In this aspect,the bipolar magnetic semiconductor(BMS)serves as an ideal solution since it can generate currents with 100%spin polarization,and the direction of spin polarization is easily tunable by an external gate voltage,Up to now,there have been lots of BMSs predicted by first-principles calculations,however,most of them are extrinsically induced by chemical or physical modifications,and a generalized scheme for designing BMS materials is stil lacking,This paper is aimed to briefly review the existing BMS materials designed by theoretical simulations,analyze the main obstacles to experimental realization,and put forward suggestions for future development.

Role of water on the H-abstraction from methanol by ClO

The influence of a single water molecule on the reaction mechanism and kinetics of hydrogen abstraction from methanol （CH3OH） by the CIO radical has been investigated using ab initio calculations. The reaction proceeds through two channels： abstraction of the hydroxyl H-atom and methyl H-atom of CH30H by CIO, leading to the formation of CH30 ＋ HOC1 （＋H20） and CH20H ＋ HOC1 （＋ H20）, respectively. In both cases, pre- and post-reactive complexes were located at the entrance and exit channel on the potential energy surfaces. Results indicate that the formation of CH2OH ＋ HOC1 （＋H20） is predominant over the formation of CH30 ＋ HOC1 （＋H20）, with ambient rate constants of 3.07 x 10^-19 and 3.01 x 10^-23 cm^3/（molecule.sec）, respectively, for the reaction without water. Over the temperature range 216.7-298.2 K, the presence of water is seen to effectively lower the rate constants for the most favorable pathways by 4-6 orders of magnitude in both cases. It is therefore concluded that water plays an inhibitive role on the CH30H ＋ ClO reaction under tropospheric conditions.