Drug-eluting stent(DES)is a promising strategy for esophageal cancer.However,full-covered drug-loaded stents cause damage to non-tumor tissue in the esophagus,and the development controlled-release system to prevent n...Drug-eluting stent(DES)is a promising strategy for esophageal cancer.However,full-covered drug-loaded stents cause damage to non-tumor tissue in the esophagus,and the development controlled-release system to prevent non-tumor tissue injure is currently a major challenge.Here,in situ mineralized manganese dioxide coating on Ce6 embedded electrospun fibers covered stent was developed for effective tumor therapy via intraluminal photodynamic therapy(PDT),which could reduce phototoxicity to normal esophageal tissue.Oxidation of manganese ions,which was previously swelled between fibers,was used to accomplish mineralization.After implantation,the manganese dioxide coating in situ reacts with tumor endogenous H^(+) and H_(2)O_(2),which,on the one hand,could effectively alleviate the hypoxic microenvironment which leads to resistance to PDT,and on the other hand,could expose the Ce6-fibers below the coating for intraluminal PDT.In addition,due to the slow degradation of the coating,this stent could own sustained photodynamic performance for up to one month.Notably,the PDT efficiency of the stent was investigated on orthotopic rabbit esophageal cancer models.Overall,this work suggests that in situ mineralized manganese dioxide coated electrospun fibers covered stent may provide a new strategy for advanced esophageal cancer patients as a functional drug delivery platform.展开更多
基金This research was funded by the National Natural Science Foundation of China(Nos.81971714,81771943,and 51873107)Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grants(Nos.20152528 and 20171906)+3 种基金Shanghai Jiao Tong University“Medical and Research”Program(Nos.ZH2018ZDA04 and ZH2018ZDA19)Shanghai Talent Development Fund(No.2018099)the Collaborative Innovation Center of Suzhou Nano Science and TechnologyL.Cheng was supported by the Tang Scholar of Soochow University。
文摘Drug-eluting stent(DES)is a promising strategy for esophageal cancer.However,full-covered drug-loaded stents cause damage to non-tumor tissue in the esophagus,and the development controlled-release system to prevent non-tumor tissue injure is currently a major challenge.Here,in situ mineralized manganese dioxide coating on Ce6 embedded electrospun fibers covered stent was developed for effective tumor therapy via intraluminal photodynamic therapy(PDT),which could reduce phototoxicity to normal esophageal tissue.Oxidation of manganese ions,which was previously swelled between fibers,was used to accomplish mineralization.After implantation,the manganese dioxide coating in situ reacts with tumor endogenous H^(+) and H_(2)O_(2),which,on the one hand,could effectively alleviate the hypoxic microenvironment which leads to resistance to PDT,and on the other hand,could expose the Ce6-fibers below the coating for intraluminal PDT.In addition,due to the slow degradation of the coating,this stent could own sustained photodynamic performance for up to one month.Notably,the PDT efficiency of the stent was investigated on orthotopic rabbit esophageal cancer models.Overall,this work suggests that in situ mineralized manganese dioxide coated electrospun fibers covered stent may provide a new strategy for advanced esophageal cancer patients as a functional drug delivery platform.
