One of the simplest models for examining the interplay between bone formation and resorption is the junction between the cranial bones.Although only roughly a quarter of patients diagnosed with craniosynostosis have b...One of the simplest models for examining the interplay between bone formation and resorption is the junction between the cranial bones.Although only roughly a quarter of patients diagnosed with craniosynostosis have been linked to known genetic disturbances,the molecular mechanisms elucidated from these studies have provided basic knowledge of bone homeostasis.This work has translated to methods and advances in bone tissue engineering.In this review,we examine the current knowledge of cranial suture biology derived from human craniosynostosis syndromes and discuss its application to regenerative medicine.展开更多
基金supported by the Jean Perkins Foundation(JCL)and the Plastic Surgery Foundation(JCL)(234813).
文摘One of the simplest models for examining the interplay between bone formation and resorption is the junction between the cranial bones.Although only roughly a quarter of patients diagnosed with craniosynostosis have been linked to known genetic disturbances,the molecular mechanisms elucidated from these studies have provided basic knowledge of bone homeostasis.This work has translated to methods and advances in bone tissue engineering.In this review,we examine the current knowledge of cranial suture biology derived from human craniosynostosis syndromes and discuss its application to regenerative medicine.
