Coactivator-independent vitamin D receptor signaling causes severe rickets in mice,that is not prevented by a diet high in calcium,phosphate,and lactose

The vitamin D receptor(VDR)plays a critical role in the regulation of mineral and bone homeostasis.Upon binding of 1α,25-dihydroxyvitamin D_(3) to the VDR,the activation function 2(AF2)domain repositions and recruits coactivators for the assembly of the transcriptional machinery required for gene transcription.