To get a clear picture of the pulsatile nature of blood flow and its role in the pathogenesis of atherosclerosis, a comparative study of blood flow in large arteries is carried out using the two widely used models, Mc...To get a clear picture of the pulsatile nature of blood flow and its role in the pathogenesis of atherosclerosis, a comparative study of blood flow in large arteries is carried out using the two widely used models, McDonald＇s and Burton＇s models, for the pressure gradient. For both models, the blood velocity in the lumen is obtained analytically. Elaborate investigations on the wall shear stress （WSS） and oscillatory shear index （OSI） are carried out. The results are in good agreement with the available data in the literature. The superiority of McDonald＇s model in capturing the pulsatile nature of blood flow, especially the OSI, is highlighted. The present investigation supports the hypothesis that not only WSS but also OSI are the essential features determining the pathogenesis of atherosclerosis. Finally, by reviewing the limitations of the present investigation, the possibility of improvement is explored.展开更多
The combined effects of the magnetic field, permeable walls, Darcy velocity, and slip parameter on the steady flow of a fluid in a channel of uniform width are studied. The fluid flowing in the channel is assumed to b...The combined effects of the magnetic field, permeable walls, Darcy velocity, and slip parameter on the steady flow of a fluid in a channel of uniform width are studied. The fluid flowing in the channel is assumed to be homogeneous, incompressible, and Newtonian. Analytical solutions are constructed for the governing equations using Beavers-Joseph slip boundary conditions. Effects of the magnetic field, permeability, Darcy velocity, and slip parameter on the axial velocity, slip velocity, and shear stress are discussed in detail. It is shown that the Hartmann number, Darcy velocity, porous parameter, and slip parameter play a vital role in altering the flow and in turn the shear stress.展开更多
文摘To get a clear picture of the pulsatile nature of blood flow and its role in the pathogenesis of atherosclerosis, a comparative study of blood flow in large arteries is carried out using the two widely used models, McDonald＇s and Burton＇s models, for the pressure gradient. For both models, the blood velocity in the lumen is obtained analytically. Elaborate investigations on the wall shear stress （WSS） and oscillatory shear index （OSI） are carried out. The results are in good agreement with the available data in the literature. The superiority of McDonald＇s model in capturing the pulsatile nature of blood flow, especially the OSI, is highlighted. The present investigation supports the hypothesis that not only WSS but also OSI are the essential features determining the pathogenesis of atherosclerosis. Finally, by reviewing the limitations of the present investigation, the possibility of improvement is explored.
文摘The combined effects of the magnetic field, permeable walls, Darcy velocity, and slip parameter on the steady flow of a fluid in a channel of uniform width are studied. The fluid flowing in the channel is assumed to be homogeneous, incompressible, and Newtonian. Analytical solutions are constructed for the governing equations using Beavers-Joseph slip boundary conditions. Effects of the magnetic field, permeability, Darcy velocity, and slip parameter on the axial velocity, slip velocity, and shear stress are discussed in detail. It is shown that the Hartmann number, Darcy velocity, porous parameter, and slip parameter play a vital role in altering the flow and in turn the shear stress.
