Proximal Femur Bionic Nail (PFBN): A Panacea for Unstable Intertrochanteric Femur Fracture

With the aging population,intertrochanteric femur fracture in the elderly has become one of the most serious public health issues and a hot topic of research in trauma orthopedics.Due to the limitations of internal fixation techniques and the insufficient mechanical design of nails,the occurrence of complications delays patient recovery after surgical treatment.Design of a proximal femur bionic nail(PFBN)based on Zhang’s N triangle theory provides triangular supporting fixation,which dramatically decreases the occurrence of complications and has been widely used for clinical treatment of unstable intertrochanteric femur fracture worldwide.In this work,we developed an equivalent biomechanical model to analyze improvement in bone remodeling of unstable intertrochanteric femur fracture through PFBN use.The results show that compared with proximal femoral nail antirotation(PFNA)and InterTan,PFBN can dramatically decrease the maximum strain in the proximal femur.Based on Frost’s mechanostat theory,the local mechanical environment in the proximal femur can be regulated into the medium overload region by using a PFBN,which may render the proximal femur in a state of physiological overload,favoring post-operative recovery of intertrochanteric femur fracture in the elderly.This work shows that PFBN may constitute a panacea for unstable intertrochanteric femur fracture and provides insights into improving methods of internal fixation.

Research and Application of Compressed Fermented Chestnut Leaf Feed in Fattening Mutton Sheep

Chestnut leaves and bran were evenly mixed according to different mass ratios,and the mixtures were sprayed and inoculated with a certain amount of prepared EM microbial liquid,and then compressed into 70 cm×40 cm×30 cm blocks by a fully automatic yellow-storage block compression and packaging machine.The obtained blocks were packaged and sealed with plastic film,and placed in a freely ventilated place for more than 15 d of anaerobic fermentation,so as to obtain compressed fermented chestnut leaf block feed.[Results]Through the detection and analysis of nutritional components in the compressed fermented chestnut leaf block feed in the laboratory,the protein content was equal to or greater than 10.2%,which was 44.68%higher than that of unfermented chestnut leaf feed;the tannin content was equal to or greater than 638 mg/kg,which was 18.41%lower than that of the original feed;and the crude fiber content was equal to or greater than 19.5%,which was 14.09%lower than that of the original feed.[Conclusions]This study improves the palatability of chestnut leaf feed,increases the use efficiency of feed and reduces feeding cost.It is worth popularizing.

从早期小细胞肺癌患者中选择以手术作为局部治疗的候选者:基于人群的分析

背景与目的手术和放疗被认为是治疗小细胞肺癌(small cell lung cancer,SCLC)的局部疗法。本研究旨在基于"第8版肺癌TNM分期指南",在I或II期SCLC患者中选择接受手术作为局部治疗的候选者。方法从监测、流行病学和最终结果(Surveillance, Epidemiology and End Results,SEER)数据库中选择在2004年至2013年间被诊断为SCLC的患者。根据"第8版肺癌TNM分期指南",对这些SCLC患者的TNM分期进行了重新分类。I或II期SCLC患者被纳入本研究。在不同TNM分期中分别比较接受手术和放疗作为局部治疗的患者间的总生存(overall survival,OS)和肺癌特异性生存(lung cancer-specific survival,LCSS)。多因素分析用于评价与生存相关的多种因素。结果在纳入本研究的2129例患者中,387例(18.2%)接受了手术治疗,1032例(48.5%)接受了放疗作为局部治疗,154例(7.2%)接受了手术和放疗,556例(26.1%)未接受任何手术或放疗。在T1–2N0期(肿瘤大小≤50 mm,无阳性淋巴结)患者中,接受手术的患者5年OS和LCSS率高于接受放疗的患者(T1N0:46.0?%vs. 23.8%,P <0.001,58.4%vs. 36.4%,P <0.001;T2N0:42.6%vs. 24.7%,P=0.004,48.8%vs. 31.3%,P=0.011)。多因素分析结果显示,手术与低死亡风险相关。然而,在T3N0或T1–2N1(IIB期)SCLC患者中,接受手术的患者5年OS和LCSS率并未高于接受放疗的患者(T3N0:16.2%vs. 26.5%,P=0.085,28.7%vs. 30.9%,P=0.372;T1–2N1:20.3%vs. 29.0%,P=0.146,25.6%vs. 35.5%,P=0.064)。结论基于绝大多数接受手术或放疗的I或II期SCLC患者也接受了特定类型的全身治疗的假设,只有T1–2N0期SCLC患者可以从作为局部治疗的手术中获益。T3N0或T1–2N1期SCLC患者可考虑将放疗作为局部治疗。

Many-body dissipative particle dynamics with energy conservation:temperature-dependent long-term attractive interaction

Heat and mass transfer during the process of liquid droplet dynamic behaviors has attracted much attention in decades.At mesoscopic scale,numerical simulations of liquid droplets motion,such as impacting,sliding,and coalescence,have been widely studied by using the particle-based method named many-body dissipative particle dynamics(MDPD).However,the detailed information on heat transfer needs further description.This paper develops a modified MDPD with energy conservation(MDPDE)by introducing a temperature-dependent long-term attractive interaction.By fitting or deriving the expressions of the strength of the attractive force,the exponent of the weight function in the dissipative force,and the mesoscopic heat friction coefficient about temperature,we calculate the viscosity,self-diffusivity,thermal conductivity,and surface tension,and obtain the Schmidt number Sc,the Prandtl number P r,and the Ohnesorge number Oh for 273 K to 373 K.The simulation data of MDPDE coincide well with the experimental data of water,indicating that our model can be used to simulate the dynamic behaviors of liquid water.Furthermore,we compare the equilibrium contact angle of droplets wetting on solid surfaces with that calculated from three interfacial tensions by MDPDE simulations.The coincident results not only stand for the validation of Young’s equation at mesoscale,but manifest the reliability of our MDPDE model and applicability to the cases with free surfaces.Our model can be extended to study the multiphase flow withcomplex heat and mass transfer.

Butterfly-Like Anisotropic Magnetoresistance and Angle-Dependent Berry Phase in a Type-ⅡWeyl Semimetal WP2

The Weyl semimetal has emerged as a new topologically nontrivial phase of matter,hosting low-energy excitations of massless Weyl fermions.Here,we present a comprehensive study of a type-ⅡWeyl semimetal WP2.Transport studies show a butterfly-like magnetoresistance at low temperature,reflecting the anisotropy of the electron Fermi surfaces.This four-lobed feature gradually evolves into a two-lobed variant with an increase in temperature,mainly due to the reduced relative contribution of electron Fermi surfaces compared to hole Fermi surfaces for magnetoresistance.Moreover,an angle-dependent Berry phase is also discovered,based on quantum oscillations,which is ascribed to the effective manipulation of extremal Fermi orbits by the magnetic field to feel nearby topological singularities in the momentum space.The revealed topological character and anisotropic Fermi surfaces of the WP2 substantially enrich the physical properties of Weyl semimetals,and show great promises in terms of potential topological electronic and Fermitronic device applications.

公众情绪如何影响工业共生链企业减排?——基于RDEU博弈模型分析

本文将包含情绪函数的等级依赖期望效应(RDEU)理论运用到工业共生链内部企业减排演化博弈中,探究公众情绪因素影响工业共生链企业减排的微观作用机制。对四种异质情绪组合分别进行均衡性分析及数值仿真。研究结果表明,双方均处于理性状态时,公众会被动接受企业排污,企业会直接排污;当公众和企业都处于悲观情绪时,适度悲观的情绪使公众妥协接受的意愿增加,企业选择处理后共生的意愿也增加,但是,过度悲观则会不利于工业共生链企业的减排,乐观情绪下的策略选择则相反;当企业处于悲观情绪时,公众乐观情绪一定限度地加深增大了公众集体抗议的概率。最后,本文从情绪管理方面提出了引导社会情绪的相关对策建议,以期更好地实现工业共生链企业减排。

Self-cleaning effect and secondary swirling clean gas for suppressing particle deposition on vortex finder of gas cyclones

In order to suppressing the particle deposition on vortex finder,a series of gas cyclones with the secondary swirling clean gas were developed inspired by the gas purge effect.Effects of the width and extension length of the flow channel as well as the secondary inlet velocity and running time on the particle deposition pattern,the deposited particle mass and the cyclones'performance were experimentally investigated,respectively.The results show that the ultrafine particles(Stokes number Stk<0.0358)are mainly loose deposited on the walls under the secondary gas.Compare to the conventional cyclone with single tangential inlet,the total deposited particle mass of the improved cyclone has a maximum reduction more than 60%,and the collecting efficiency is increased up to 97.5%under the basically same pressure drop.The corresponding no-deposition area is increased by about 13%,and remains constant in spite of extending the running time.Moreover,an interesting phenomenon named"self-cleaning effect"of the vortex finder was captured for the gas cyclones,and mechanism of the secondary clean gas on the particle deposition is preliminarily analyzed.The results can deepen the understanding of the particle deposition on the vortex finder and guide the design of the anti-coking gas cyclones.

我国杂粮种质资源创新研究:现状与展望

该文系统综述了我国杂粮种质资源保存、鉴定评价、创新利用、基因资源挖掘研究现状,以及基础研究存在的问题和挑战,并提出杂粮研究的重点和发展方向。

An improved state-of-charge estimation method for sodium-ion battery based on combined correction of voltage and internal resistance

ABSTRACT The accurate state-of-charge(SOC)estimation of sodium-ion batteries is the basis for their efficient application.In this paper,a new SOC estimation method suitable for sodium-ion batteries and their application conditions is proposed,which considers the combination of open circuit voltage(OCV)and internal resistance correction.First,the optimal order of equivalent circuit model is analyzed and selected,and the monotonic and stable mapping relationships between OCV and SOC,as well as between ohmic internal resistance and SOC are determined.Then,a joint estimation algorithm for battery model parameters and SOC is estab-lished,and a joint SOC correction strategy based on OCV and ohmic internal resistance is established.The test results show that OCV correction is reliable when polarization is small,that the ohmic internal resistance correction is reliable when the current fluctuation is large,and that the maximum absolute error of SOC estimation of the proposed method is not more than 2.6%.

Selection of candidates for surgery as local therapy among early-stage small cell lung cancer patients: a population-based analysis

Background:Surgery and radiotherapy are considered local therapies for small cell lung cancer(SCLC).The present study aimed to select candidates for surgery as local therapy among patients with stage I or II SCLC,based on the eighth edition of the TNM classification for lung cancer.Methods:Patients diagnosed with SCLC between 2004 and 2013 were selected from the Surveillance,Epidemiology,And End Results database.The TNM stage of SCLC in these patients was re-classified according to the eighth edition of the TNM classification for lung cancer.Patients with stage I or II SCLC were included in the present study.Overall survival(OS)and lung cancer-specific survival(LCSS)were separately compared in the different TNM stages between patients who received surgery and radiotherapy as local therapy.Multivariate analysis was applied to evaluate multi-ple factors associated with survival.Results:Among the 2129 patients included in the present study,387(18.2%)received surgery,1032(48.5%)under-went radiotherapy as local therapy,154(7.2%)underwent surgery and radiotherapy,and 556(26.1%)did not undergo either surgery or radiotherapy.Among patients with T1-2N0(tumor size≤50 mm without positive lymph nodes)dis-ease,patients who underwent surgery had higher 5-year OS and LCSS rates than patients who received radiotherapy(T1N0:46.0%vs.23.8%,P<0.001,and 58.4%vs.36.4%,P<0.001,respectively;T2N0:42.6%vs.24.7%,P=0.004,and 48.8%vs.31.3%,P=0.011,respectively).Multivariate analysis results revealed that surgery was associated with low risk of death.However,among T3N0 or T1-2N1(stage IIB)SCLC patients,patients who underwent surgery did not have higher 5-year OS and LCSS rates than patients who received radiotherapy(T3N0:16.2%vs.26.5%,P=0.085,and 28.7%vs.30.9%,P=0.372,respectively;T1-2N1:20.3%vs.29.0%,P=0.146,and 25.6%vs.35.5%,P=0.064,respectively).Conclusions:Based on the assumption that the overwhelming majority of stage I or II SCLC patients who underwent surgery or radiotherapy also received certain types of systemic therapy,only patients with T1-2N0 SCLC may benefit from surgery as local therapy.Patients with T3N0 or T1-2N1 SCLC may consider radiotherapy as local therapy.

Effect of age on the pharmacokinetics of polymorphic nimodipine in rats after oral administration

The previous investigation has proved that their existed pharmacokinetic difference between the different crystal forms of the polymorphic drugs after oral administration.However,no systemic investigations have been made on the change of this pharmacokinetic difference,resulted either from the physiological or from the pathological factors.In this paper,we used polymorphic nimodipine(Nim) as a model drug and investigated the effect of age difference(2- and 9-month old) on the pharmacokinetics after oral delivery in rats.As the results shown,for L-form of Nim(L-Nim),the AUC0–24 hin 2-month-old rats was 343.68747.15 ng h/m L,which is 23.36% higher than that in 9-month-old rats.For H-form of Nim(H-Nim),the AUC0–24 hin 2-monthold rats was 140.91719.47 ng h/m L,which is 54.64% higher than that in 9-month-old rats.The AUC0–24 h ratio between H-Nim and L-Nim was 2.44 in 2-month-old rats and 3.06 in 9-month-old rats.Since age difference could result in unparallelled change of the absorption and bioavailability of the polymorphic drugs,the results in this experiment are of value for further investigation of crystal form selection in clinical trials and rational clinical application of the polymorphic drugs.

Hybrid Dirac semimetal-based photodetector with efficient low-energy photon harvesting

Despite the considerable effort,fast and highly sensitive photodetection is not widely available at the low-photon-energy range(~meV)of the electromagnetic spectrum,owing to the challenging light funneling into small active areas with efficient conversion into an electrical signal.Here,we provide an alternative strategy by efficiently integrating and manipulating at the nanoscale the optoelectronic properties of topological Dirac semimetal PtSe_(2)and its van der Waals heterostructures.Explicitly,we realize strong plasmonic antenna coupling to semimetal states near the skin-depth regime(λ/10^(4)),featuring colossal photoresponse by in-plane symmetry breaking.The observed spontaneous and polarization-sensitive photocurrent are correlated to strong coupling with the nonequilibrium states in PtSe_(2)Dirac semimetal,yielding efficient light absorption in the photon range below 1.24 meV with responsivity exceeding∼0.2 A/W and noise-equivalent power(NEP)less than~38 pW/Hz^(0.5),as well as superb ambient stability.Present results pave the way to efficient engineering of a topological semimetal for high-speed and low-energy photon harvesting in areas such as biomedical imaging,remote sensing or security applications.

Controllable growth of type-II Dirac semimetal PtTe2 atomic layer on Au substrate for sensitive room temperature terahertz photodetection

Platinum telluride(PtTe_(2)),a member of metallic transition metal dichalcogenides,provides a new platform for investigating various properties such as type-II Dirac fermions,topological superconductivity,and wide-band photodetection.However,the study of PtTe_(2)is largely limited to exfoliated flakes,and its direct synthesis remains challenging.Herein,we report the controllable synthesis of highly crystalline 2D PtTe_(2)crystals with tunable morphology and thickness via chemical vapor deposition(CVD)growth on Au substrate.By adjusting Te amount and substrate temperature,anisotropic and isotropic growth modes of PtTe_(2)were realized on the solid and molten Au substrates,respectively.The domain size of PtTe_(2)crystal was achieved up to 30μm,and its thickness can be tuned from 5.6 to 50 nm via controlling the growth time.Furthermore,a metal–PtTe_(2)–metal structural device was fabricated to validate the wide-band terahertz(THz)photodetection from 0.04 to 0.3 THz at room temperature.Owing to the high crystallinity of PtTe_(2)crystal,the photodetector acquires high responsivity(30–250 mA W-1 from 0.12 to 0.3 THz),fast response rate(rise time:7μs,decay time:8μs),and high-quality imaging ability.Our work demonstrates the feasibility for realistic exploitation of high-performing photodetection system at THz band based on the CVDgrown 2D Dirac semimetal materials.

DEAP1 encodes a fasciclin-like arabinogalactan protein required for male fertility in rice

Arabinogalactan proteins(AGPs)are widely distributed in plant cells.Fasciclin-like AGPs(FLAs)belong to a subclass of AGPs that play important roles in plant growth and development.However,little is known about the biological functions of rice FLA.Herein,we report the identification of a male-sterile mutant of DEFECTIVE EXINE AND APERTURE PATTERNING1(DEAP1)in rice.The deap1 mutant anthers produced aberrant pollen grains with defective exine formation and a flattened aperture annulus and exhibited slightly delayed tapetum degradation.DEAP1 encodes a plasma membrane-associated member of groupⅢplant FLAs and is specifically and temporally expressed in reproductive cells and the tapetum layer during male development.Gene expression studies revealed reduced transcript accumulation of genes related to exine formation,aperture patterning,and tapetum development in deap1 mutants.Moreover,DEAP1 may interact with two rice D6 PROTEIN KINASE-LIKE3 s(OsD6PKL3s),homologs of a known Arabidopsis aperture protein,to affect rice pollen aperture development.Our findings suggested that DEAP1 is involved in male reproductive development and may affect exine formation and aperture patterning,thereby providing new insights into the molecular functions of plant FLAs in male fertility.

Continuum electron giving birth to terahertz emission

The origin of terahertz(THz)generation in a gas-phase medium is still in controversy,although the THz sources have been applied across many disciplines.Herein,the THz generation in a dual color field is investigated experimentally by precisely controlling the relative phase and polarization of dual-color lasers,where the accompanying third-harmonic generation is employed for in situ determination of the relative phase up to sub-wavelength accuracy.Joint studies with the strong approximation(SFA)theory reveal that the continuum-continuum(CC)transition within an escaped electron wave packet in the single atom gives birth to THz emission,without the necessity of considering the plasma effect.Meanwhile,we develop the analytic form from SFA-based CC description,which is able to reproduce and decompose the classical photocurrent model from the viewpoint of microscopic quantum theory,establishing the quantum-lassical correspondence and bringing a novel insight into the mechanism of THz generation.Present studies leave open the possibility for probing the ultrafast dynamics of continuum electrons and a new dimension for the study of THz-related science and methodology.

Drug research and development opportunities in low-and middle-income countries:accelerating traditional medicine through systematic utilization and comprehensive synergy

Background:Though the utilization of traditional medicine has been proposed for modern drug research and development(R&D),limited research has discussed its feasible paths.In this commentary,we summarized key factors for new drug R&D under limited resources by reviewing China’s discovery of artemisinin,and raised suggestions to utilize traditional medicines in low-and middle-income countries(LMICs).Main text:We suggested that systematic utilization of traditional medicine,outstanding synergy of research units at all levels and timely information-sharing mechanism should be achieved to establish a comprehensive and efficient R&D system,especially under low-resource settings.In the case of artemisinin discovery,Chinese scientists integrated documented traditional medicine experiences and modern approaches to develop drug candidates timely.Due to limited R&D resources,China adopted a collaborative way,motivating nearly all domestic research units at different levels,to develop antimalarial products.Moreover,the excellent synergy among all units through efficient information-sharing mechanisms greatly avoided work repetition and accelerated the R&D process.Conclusion:Traditional medicines inspires drug discoveries in LMICs,while a comprehensive and efficient R&D system could accelerate its R&D process and save investment.The discovery of artemisinin in China gave a reliable pattern to promote sustainable development of traditional medicines and a good example to realize R&D of traditional medicine under low-resource settings.

A review of occluded objects detection in real complex scenarios for autonomous driving

Autonomous driving is a promising way to future safe,efficient,and low-carbon transportation.Real-time ac-curate target detection is an essential precondition for the generation of proper following decision and control signals.However,considering the complex practical scenarios,accurate recognition of occluded targets is a major challenge of target detection for autonomous driving with limited computational capability.To reveal the overlap and difference between various occluded object detection by sharing the same available sensors,this paper presents a review of detection methods for occluded objects in complex real-driving scenarios.Considering the rapid development of autonomous driving technologies,the research analyzed in this study is limited to the recent five years.The study of occluded object detection is divided into three parts,namely occluded vehicles,pedes-trians and traffic signs.This paper provided a detailed summary of the target detection methods used in these three parts according to the differences in detection methods and ideas,which is followed by the comparison of advantages and disadvantages of different detection methods for the same object.Finally,the shortcomings and limitations of the existing detection methods are summarized,and the challenges and future development prospects in this field are discussed.

Comparative and population genomics of buckwheat species reveal key determinants of flavor and fertility

Common buckwheat(Fagopyrum esculentum)is an ancient crop with a world-wide distribution.Due to its excellent nutritional quality and high economic and ecological value,common buckwheat is becoming increasingly important throughout the world.The availability of a high-quality reference genome sequence and population genomic data will accelerate the breeding of common buckwheat,but the high heterozygosity due to the outcrossing nature has greatly hindered the genome assembly.Here we report the assembly of a chromosome-scale high-quality reference genome of F.esculentum var.homotropicum,a homozygous self-pollinating variant of common buckwheat.Comparative genomics revealed that two cultivated buckwheat species,common buckwheat(F.esculentum)and Tartary buckwheat(F.tataricum),underwent metabolomic divergence and ecotype differentiation.The expansion of several gene families in common buckwheat,including FhFAR genes,is associated with its wider distribution than Tartary buckwheat.Copy number variation of genes involved in the metabolism of flavonoids is associated with the difference of rutin content between common and Tartary buckwheat.Furthermore,we present a comprehensive atlas of genomic variation based on whole-genome resequencing of 572 accessions of common buckwheat.Population and evolutionary genomics reveal genetic variation associated with environmental adaptability and floral development between Chinese and non-Chinese cultivated groups.Genome-wide association analyses of multi-year agronomic traits with the content of flavonoids revealed that Fh05G014970 is a potential major regulator of flowering period,a key agronomic trait controlling the yield of outcrossing crops,and that Fh06G015130 is a crucial gene underlying flavor-associated flavonoids.Intriguingly,we found that the gene translocation and sequence variation of FhS-ELF3 contribute to the homomorphic self-compatibility of common buckwheat.Collectively,our results elucidate the genetic basis of speciation,ecological adaptation,fertility,and unique flavor of common buckwheat,and provide new resources for future genomics-assisted breeding of this economically important crop.

Target slinging of droplets with a flexible cantilever

Control of the directional bounce of droplets impacting solid surfaces is crucial for many agricultural and industrial applications.However,for the universal impact process of raindrops on plant leaves,little is known about how the highly coupled and complicated fluid–structure interaction controls the postimpact motion of droplets and endows the leaves with tenacious vitality.Here,we report a leaf-like superhydrophobic cantilever to flexibly bounce droplets with well-defined directionality and controllability.Through theoretical modeling and three-dimensional fluid–solid coupling simulations,we find that the flexible cantilever significantly relieves the impacting forces of raindrops to reduce droplet fragmentation and enhance water repellency.The results further uncover the scaling relations of the droplet bouncing direction with respect to Weber number and cantilever stiffness.By this technique,the seemed disorganized postimpact movements of droplets are programmable and predictable,achieving the goal of where to point and where to hit automatically.This work advances the understanding of natural droplet impact phenomena,opens a new avenue for delicately controlling liquid motion in space with soft materials,and inspires a plethora of applications like soft robots to transport materials and energies,monitor plant growth as well as predict pathogen transmission in plants.

Jasmonate-responsive gene FtoPR involved in flavonoid synthesis in Tartary buckwheat

Crop domestication has long been regarded as an evolutionary processbecause the development of new and improvedcultivars isbased on selection.Many domesticated crops possess a suite of selected characteristics such as plant architecture,seed shattering,and inflorescence-related traits(Shi and Lai,2015).Alteration of secondary metabolites has also become a common domestication trait.However,it seems to be somewhat overlooked(Alseekh et al.,2021).