目的了解中医药调控Th17/Treg平衡研究热点和发展趋势。方法检索中国知识资源总库(CNKI)、中文科技期刊数据库(VIP)、中国学术期刊数据库(万方数据)和Web of Science收录的2010年1月1日-2022年4月30日中医药调控Th17/Treg平衡研究文献...目的了解中医药调控Th17/Treg平衡研究热点和发展趋势。方法检索中国知识资源总库(CNKI)、中文科技期刊数据库(VIP)、中国学术期刊数据库(万方数据)和Web of Science收录的2010年1月1日-2022年4月30日中医药调控Th17/Treg平衡研究文献。采用NoteExpress3.6.0和EndNoteX9进行去重及人工筛选,采用Excel2019绘制纳入文献发文时间趋势图,采用VOSviewer1.6.18软件绘制核心作者密度视图和关键词共现分析图谱,采用CiteSpace5.8.R3软件对关键词进行聚类分析、突现分析及时间线分析。结果共纳入313篇中文文献和338篇英文文献,该领域发文量逐年增加,涉及1445名中文作者和2293名英文作者,中文文献形成了以姚成芳、刘宇、彭杰、朱小勤等为代表的研究团队,英文文献形成了以Liu Jian、Dai Zhenhua等为代表的研究团队。中、英文文献关键词各形成了10个有意义的聚类,显示该领域研究热点主要集中于哮喘、溃疡性结肠炎、多发性硬化症、类风湿关节炎等疾病;备受关注的中药复方及单体为芍药汤、左归丸、三拗汤、信筒子醌、射干苷等,针灸疗法的干预机制同样是研究热点;主要涉及TGF-β、IL-10、IL-23、Foxp3、TNF-α等因子及NF-κB、Akt等信号通路的研究。结论中医药调控Th17/Treg平衡的相关研究近年逐渐增多,发展前景良好,Th17/Treg平衡有望成为中医药治疗免疫、炎症、肿瘤等多类疾病相关研究的核心靶点,但该领域总体发文量较少,作者所在团队之间合作不甚紧密,研究者除扩大经典中药复方在该领域的研究外,对针灸疗法及穴位纳米复合水凝胶这类新颖、有效的治疗策略的机制研究亦需深入挖掘。展开更多
Hydration heat behavior and kinetics of blended cement containing up to 20% MSWI fly ash were investigated based on its hydration heat evolution rate measured by isothermal calorimeter. Kinetics parameters, N and K, a...Hydration heat behavior and kinetics of blended cement containing up to 20% MSWI fly ash were investigated based on its hydration heat evolution rate measured by isothermal calorimeter. Kinetics parameters, N and K, and hydration degree, Ca(OH)2 content, were also calculated and analyzed. According to the experimental results, the induction period was elongated, the second heat evolution peak was in advance, and the third hydration heat peak could be detected due to MSWI fly ash pozzolanic reaction. The hydration reaction rate was controlled by nucleation kinetics in the acceleration period and then by diffusion in the decay period, but in the deceleration period, the hydration experienced a dual controlling reaction of autocatalytic chemical reaction and diffusion. The hydration rate of blended cement was faster. Ca(OH)2 content increased before 14 days.展开更多
文摘目的了解中医药调控Th17/Treg平衡研究热点和发展趋势。方法检索中国知识资源总库(CNKI)、中文科技期刊数据库(VIP)、中国学术期刊数据库(万方数据)和Web of Science收录的2010年1月1日-2022年4月30日中医药调控Th17/Treg平衡研究文献。采用NoteExpress3.6.0和EndNoteX9进行去重及人工筛选,采用Excel2019绘制纳入文献发文时间趋势图,采用VOSviewer1.6.18软件绘制核心作者密度视图和关键词共现分析图谱,采用CiteSpace5.8.R3软件对关键词进行聚类分析、突现分析及时间线分析。结果共纳入313篇中文文献和338篇英文文献,该领域发文量逐年增加,涉及1445名中文作者和2293名英文作者,中文文献形成了以姚成芳、刘宇、彭杰、朱小勤等为代表的研究团队,英文文献形成了以Liu Jian、Dai Zhenhua等为代表的研究团队。中、英文文献关键词各形成了10个有意义的聚类,显示该领域研究热点主要集中于哮喘、溃疡性结肠炎、多发性硬化症、类风湿关节炎等疾病;备受关注的中药复方及单体为芍药汤、左归丸、三拗汤、信筒子醌、射干苷等,针灸疗法的干预机制同样是研究热点;主要涉及TGF-β、IL-10、IL-23、Foxp3、TNF-α等因子及NF-κB、Akt等信号通路的研究。结论中医药调控Th17/Treg平衡的相关研究近年逐渐增多,发展前景良好,Th17/Treg平衡有望成为中医药治疗免疫、炎症、肿瘤等多类疾病相关研究的核心靶点,但该领域总体发文量较少,作者所在团队之间合作不甚紧密,研究者除扩大经典中药复方在该领域的研究外,对针灸疗法及穴位纳米复合水凝胶这类新颖、有效的治疗策略的机制研究亦需深入挖掘。
基金Funded by the National Natural Science Foundation of China(No.51172164)
文摘Hydration heat behavior and kinetics of blended cement containing up to 20% MSWI fly ash were investigated based on its hydration heat evolution rate measured by isothermal calorimeter. Kinetics parameters, N and K, and hydration degree, Ca(OH)2 content, were also calculated and analyzed. According to the experimental results, the induction period was elongated, the second heat evolution peak was in advance, and the third hydration heat peak could be detected due to MSWI fly ash pozzolanic reaction. The hydration reaction rate was controlled by nucleation kinetics in the acceleration period and then by diffusion in the decay period, but in the deceleration period, the hydration experienced a dual controlling reaction of autocatalytic chemical reaction and diffusion. The hydration rate of blended cement was faster. Ca(OH)2 content increased before 14 days.
