There is no efficient tracking system available for the therapeutic molecules delivered to cartilage.The dense matrix covering the cartilage surface is the main biological barrier that the therapeutic molecules must o...There is no efficient tracking system available for the therapeutic molecules delivered to cartilage.The dense matrix covering the cartilage surface is the main biological barrier that the therapeutic molecules must overcome.In this study,we aimed to establish a system that can dynamically and effectively track the therapeutic molecules delivered to cartilage.To this aim,we adopted bovine and human cartilage explants as ex vivo models for chondrocyte-targeted exosome dispersion.The efficiency of drug delivery was evaluated using frozen sections.The results of this study showed that the penetration and distribution of chondrocyte-targeted exosomes in cartilage explants can be tracked dynamically.Thus,ex vivo cartilage explants provide an effective and economic system to evaluate therapeutic drugs encapsulated in chondrocyte-targeted exosomes in preclinical studies.展开更多
We have read with great interest the article "Heterotopic ossification after arthroscopy for hip impingement syndrome" by Gao et al.[1] The authors showed the incidence of heterotopic ossification (HO) is an...We have read with great interest the article "Heterotopic ossification after arthroscopy for hip impingement syndrome" by Gao et al.[1] The authors showed the incidence of heterotopic ossification (HO) is an observed complication after hip arthroscopy for hip impingement syndrome which is not common (5.4%,13/242) and most HO has no or little effect on clinical symptoms.We also agree with them that oral nonsteroidal anti-inflammatory drugs (NSAIDs) are beneficial in the prevention of HO after primary hip arthroscopy.Although we agree with the conclusion similar to our previous studies in the clinic,there are some issues we like to comment on.展开更多
基金National Natural Science Foundation of China(Nos.81972116,81972085,81772394,31900046)Key Program of Natural Science Foundation of Guangdong Province(No.2018B0303110003)+3 种基金Guangdong International Cooperation Project(No.2021A0505030011)Shenzhen Science and Technology Projects(Nos.GJHZ20200731095606019,JCYJ20170817172023838,JCYJ20170306092215436,JCYJ20170413161649437)China Postdoctoral Science Foundation(No.2020M682907)Special Funds for the Construction of High Level Hospitals in Guangdong Province.
文摘There is no efficient tracking system available for the therapeutic molecules delivered to cartilage.The dense matrix covering the cartilage surface is the main biological barrier that the therapeutic molecules must overcome.In this study,we aimed to establish a system that can dynamically and effectively track the therapeutic molecules delivered to cartilage.To this aim,we adopted bovine and human cartilage explants as ex vivo models for chondrocyte-targeted exosome dispersion.The efficiency of drug delivery was evaluated using frozen sections.The results of this study showed that the penetration and distribution of chondrocyte-targeted exosomes in cartilage explants can be tracked dynamically.Thus,ex vivo cartilage explants provide an effective and economic system to evaluate therapeutic drugs encapsulated in chondrocyte-targeted exosomes in preclinical studies.
文摘We have read with great interest the article "Heterotopic ossification after arthroscopy for hip impingement syndrome" by Gao et al.[1] The authors showed the incidence of heterotopic ossification (HO) is an observed complication after hip arthroscopy for hip impingement syndrome which is not common (5.4%,13/242) and most HO has no or little effect on clinical symptoms.We also agree with them that oral nonsteroidal anti-inflammatory drugs (NSAIDs) are beneficial in the prevention of HO after primary hip arthroscopy.Although we agree with the conclusion similar to our previous studies in the clinic,there are some issues we like to comment on.
