Quantitative identification of compounds-dependent on-modules and differential allosteric modules from homologous ischemic networks

Module-based methods have made much progress in deconstructing biological networks.However,it is a great challenge to quantitatively compare the topological structural variations of modules(allosteric modules,AMs)under different situations.A total of 23,42 and 15co-expression modules were identified in baicalin(BA),jasminoidin(JA)and ursodeoxycholic acid(UA)in a global anti-ischemic mice network,respectively.Then,we integrated the methods of module-based consensus ratio(MCR)and modified Z summary module statistic to validate 12 BA,22 JA and 8 UA on-modules based on comparing with vehicle.The MCRs for pairwise comparisons were 1.55%(BA vs JA),1.45%(BA vs UA),and1.27%(JA vs UA),respectively.Five conserved allosteric modules(CAMs)and 17 unique allosteric modules(UAMs)were identified among these groups.In conclusion,module-centric analysis may provide us a unique approach to understand multiple pharmacological mechanisms associated with differential phenotypes in the era of modular pharmacology.

老年综合评估在慢阻肺护理中的临床应用分析

目的探究分析老年综合评估在慢性阻塞性肺疾病(慢阻肺)护理中的临床应用。方法 93例老年慢阻肺患者,随机分为实验组(47例)和对照组(46例)。实验组采用老年综合评估,对照组采用一般护理评估。比较两组患者的临床护理效果。结果干预前,两组患者症状评分、活动评分、影响评分、肺功能评分比较差异无统计学意义(t=0.9901、0.2558、0.4716、1.2418,P>0.05)。干预后,实验组患者症状评分、活动评分、影响评分明显低于对照组,肺功能评分明显高于对照组,差异具有统计学意义(t=4.0755、4.8927、6.7148、2.3815,P<0.05)。结论对老年慢阻肺患者实施老年综合评估能够有效提升护理水平,临床效果显著,值得推广使用。