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中医治疗结肠癌相关性Lambert-Eaton肌无力综合征1例报道
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作者 柯见龙 李梓涵 +2 位作者 吴国玉 王小艳 熊绍权 《中医肿瘤学杂志》 2021年第6期72-76,共5页
本文报道介绍一例临床接诊的结肠腺癌术后化疗后继发Lambert-Eaton肌无力综合征的罕见病例,经由中药处方五苓散合补中益气汤加减治疗后患者肌无力症状得以控制,摆脱轮椅,生存质量提高。诊疗过程中主要运用的《黄帝内经》“治痿独取阳明... 本文报道介绍一例临床接诊的结肠腺癌术后化疗后继发Lambert-Eaton肌无力综合征的罕见病例,经由中药处方五苓散合补中益气汤加减治疗后患者肌无力症状得以控制,摆脱轮椅,生存质量提高。诊疗过程中主要运用的《黄帝内经》“治痿独取阳明”相关理论,通过辨证论治,取掉较好疗效,本文就疾病机理、中医辨治思路进行探讨,以供临床参考。 展开更多
关键词 LAMBERT-EATON肌无力综合征 结肠癌 《黄帝内经》 太阴阳明
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AY358935基因抗水疱口炎病毒的作用及其机制探讨
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作者 黎光平 柯见龙 +5 位作者 吕盼盼 朱茜 王翠 王金阳 申显英 熊绍权 《四川大学学报(医学版)》 CAS CSCD 北大核心 2019年第4期540-545,共6页
目的初步探讨本课题组前期克隆的AY358935基因对水疱口炎病毒(vesicular stomatitis virus,VSV)的作用及机制。方法将构建完整的pcDNA3.1-AY358935质粒及pcDNA3.1空载体分别稳定转染HEK293细胞,并以VSV感染已转染上述基因或空白的HEK29... 目的初步探讨本课题组前期克隆的AY358935基因对水疱口炎病毒(vesicular stomatitis virus,VSV)的作用及机制。方法将构建完整的pcDNA3.1-AY358935质粒及pcDNA3.1空载体分别稳定转染HEK293细胞,并以VSV感染已转染上述基因或空白的HEK293细胞,感染复数(multiplicity of infection,MOI)为0.001。蚀斑分析法检测以上3组细胞上清液中不同时间点的病毒滴度,感染VSV 24 h后用台盼蓝排斥试验检测各组细胞死亡率;对稳定转染目的基因的细胞提取总RNA,进行全基因组cDNA芯片分析。结果①病毒滴度:感染VSV 12 h后,pcDNA3.1-AY358935组细胞上清病毒滴度较pcDNA3.1组和空白组低。18 h时3组病毒滴度分别为(7.16±2.33)×10^5 PFU/mL、(6.25±2.05)×10^6 PFU/mL、(7.75±2.54)×10^6 PFU/mL,pcDNA3.1-AY358935组细胞上清病毒滴度与其余两组的差异接近10倍(P<0.01);②细胞死亡率:病毒感染24 h后,pcDNA3.1-AY358935组、pcDNA3.1组和空白组的细胞死亡率分别为(35.00±6.68)%、(78.33±15.03)%和(83.34±14.98)%,pcDNA3.1-AY358935组的细胞死亡率较其余两组降低(P<0.01);③基因芯片分析结果:与pcDNA3.1空载体组比较,稳定转染pcDNA3.1-AY358935的细胞有30个基因表达上调在3倍以上,其中,干扰素激活基因、干扰素效应基因、细胞因子与趋化因子所占比例分别为27%、17%、20%。结论 AY358935基因具有抗VSV作用,其机制可能涉及干扰素相关的天然免疫应答。 展开更多
关键词 AY358935基因 VSV 干扰素
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Usage of Chinese Herbs in Cancer Patients in Southern China:A Survey
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作者 XIONG Shao-quan CHEN Yu +9 位作者 WANG Li-juan LYU Pan-pan LIAO Wan WANG Cui ke jian-long ZHU Xi WANG Jin-yang SHEN Xian-ying LI Guang-ping LIN Li-zhu 《Chinese Journal of Integrative Medicine》 SCIE CAS CSCD 2021年第7期502-508,共7页
Objective To study the use of Chinese medicine(CM)in cancer patients in southern China.Methods A total of 1,950 cancer patients finished questionnaires in four provinces in southern China.The survey included socio-dem... Objective To study the use of Chinese medicine(CM)in cancer patients in southern China.Methods A total of 1,950 cancer patients finished questionnaires in four provinces in southern China.The survey included socio-demographic and clinical characteristics of participants,dosage forms,efficacy,and side effects.Results The study results showed that cancer patients with higher education(>12 years)were more likely to accept the treatment of Chinese herbs.There were 54.61%(1,065 cases)of patients chose Chinese herbs for the initial treatment and 14.46%(282 cases)chose Chinese herbs as monotherapy.Most patients(54.51%,1,063 cases)continuously used CM for more than 6 months,and a few of them(212 cases)used CM for up to 3 years.All kinds of dosage forms of CM had been used,including CM decoction,CM patent prescription and CM injection.Concerning the efficacy in the view of patients,40.31%(786 cases)believed that it would be effective to take Chinese herbs before they starting the anti-cancer treatment,and the percentage increased to 81.08%after 1-month CM treatment.The effect of Chinese herbs was mainly demonstrated by symptom relief and improvement of quality of life,and 8.31%(162 cases)of patients experienced control of tumor growth and decreased tumor markers.Furthermore,only 14.31%(279 cases)participants reported that they experienced side effects during CM treatment.Conclusion This large scale investigation reflects the current situation of domestic CM usage objectively and comprehensively,which might provide new ways for cancer treatment. 展开更多
关键词 Chinese medicine HERBS cancer South China efficacy side and toxic effect
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