Under the background of new engineering,the reform of the comprehensive practical course system for mechanical and electronic engineering majors actively responds to the challenges posed by the new round of technologi...Under the background of new engineering,the reform of the comprehensive practical course system for mechanical and electronic engineering majors actively responds to the challenges posed by the new round of technological revolution and industrial transformation to higher education,cultivating top-notch innovative intellectuals with comprehensive engineering qualities,meeting the requirements of being able to solve complex engineering problems rather than just cognitive capabilities,forming two core courses through reconstructing and reshaping the core courses of the major.The core courses include Drive,Measurement,and Control I and Drive,Measurement,and Control II,which highlight the comprehensive framework of mechanical and electronic engineering professional knowledge,continuing the comprehensive practical course system based on the unity of knowledge and practice,following the trend of new engineering,highlighting the practicality of professional innovation,assisting engineering education reform,and promoting high-quality development of new engineering professionals cultivation.展开更多
BACKGROUND:A20 may be a neuroprotective factor.Herein,we aimed to investigate whether serum A20 levels were associated with disease severity,delayed cerebral ischemia(DCI),and outcome after aneurysmal subarachnoid hem...BACKGROUND:A20 may be a neuroprotective factor.Herein,we aimed to investigate whether serum A20 levels were associated with disease severity,delayed cerebral ischemia(DCI),and outcome after aneurysmal subarachnoid hemorrhage(aSAH).METHODS:In this prospective cohort study containing 112 aSAH patients and 112 controls,serum A20 levels were quantified.At 90 d poststroke,Modified Rankin Scale(MRS) scores≥3 were defined as a poor outcome.All correlations and associations were assessed using multivariate analysis.RESULTS:Compared with controls,there was a significant elevation of serum A20 levels in patients(median 123.7 pg/mL vs.25.8 pg/mL;P<0.001).Serum A20 levels were independently correlated with Hunt-Hess scores(β 9.854;95% confidence interval [95% CI] 2.481-17.227,P=0.009) and modified Fisher scores(β 10.349,95% CI 1.273-19.424,P=0.026).Independent associations were found between serum A20 levels and poor outcome(odds ratio [OR] 1.015,95%CI 1.000-1.031,P=0.047) and DCI(OR 1.018,95% CI 1.001-1.035,P=0.042).Areas under the curve for predicting poor outcome and DCI were 0.771(95% CI 0.682-0.845) and 0.777(95% CI 0.688-0.850),respectively.Serum A20 levels ≥128.15 pg/mL predicted poor outcome,with a sensitivity of 73.9% and specificity of 74.2%,and A20 levels ≥160.55 pg/mL distinguished the risk of DCI with65.5% sensitivity and 89.2% specificity.Its ability to predict poor outcome and DCI was similar to those of Hunt-Hess scores and modified Fisher scores(both P>0.05).CONCLUSION:Enhanced serum A20 levels are significantly associated with stroke severity and poor clinical outcome after aSAH,implying that serum A20 may be a potential prognostic biomarker for aSAH.展开更多
With the arrival of the intelligence era of Industry 4.0,social development has shown complex and diversified characteristics,gradually forming an innovation ecological environment constructed by vertical interaction ...With the arrival of the intelligence era of Industry 4.0,social development has shown complex and diversified characteristics,gradually forming an innovation ecological environment constructed by vertical interaction of multi-layer innovation systems and horizontal collaboration of multiple organizations and departments,which has posed extremely challenging requirements for higher engineering education to cultivate engineering talents with comprehensive engineering qualities who can solve complex engineering problems.However,practical engineering problems may involve a complex knowledge chain of interdisciplinary and multi-disciplinary cross-coupling.Therefore,higher engineering education needs to form a new interdisciplinary and multi-disciplinary integrated engineering innovation talent training system.Based on the characteristics of the mechanical and electronic engineering major,we will reshape and reconstruct the core courses of the mechanical and electronic engineering major.Two core courses are formed:Drive and Measurement and Control I and Drive and Measurement and Control II,with information flow and energy flow as the main lines,following up with the comprehensive practical curriculum system based on the unity of knowledge and practice and ability-oriented thinking,supporting teaching objectives,promoting students’individual development,and providing guidelines for relevant curriculum reforms.展开更多
Using of diffractive optical elements (DOE) in the Schupmann system offer a new way for the construction of ultra-large aperture telescope. The Fresnel Corrector, one of the DOEs, is the key device in the Schupmann sy...Using of diffractive optical elements (DOE) in the Schupmann system offer a new way for the construction of ultra-large aperture telescope. The Fresnel Corrector, one of the DOEs, is the key device in the Schupmann system, which is used to correct the chromatic aberration introduced by the diffractive primary lens called Magnifying Glass. Generally, in a large aperture telescope (>20 m), the Fresnel Corrector is a diffractive lens with a large aperture and a small f-number, which is difficult to process. In this article, an improved device with a small F number but a large rim feature size, called amplitude and phase hybrid modulation Fresnel diffractive optical element (APHMFDOE), is used here as the Fresnel corrector. First, APHMFDOE with appropriate parameters is designed to match the dispersion of the Magnifying Glass so that the system meets the achromatic condition. Second, the optical characteristics of this improved system are simulated and compared with those of the general system based on the conventional Fresnel corrector. Our approach introduces a new dispersion correction device, which not only can eliminate the chromatic aberration caused by Magnifying Glass, but also can reduce the processing difficulty of Fresnel Corrector.展开更多
According to the GFCI ranking from 2018-2020,Hong Kong fell from third to sixth,surpassing cities in other Asian countries and some inland cities in China.Hong Kong’s marginalization has intensified because of the im...According to the GFCI ranking from 2018-2020,Hong Kong fell from third to sixth,surpassing cities in other Asian countries and some inland cities in China.Hong Kong’s marginalization has intensified because of the impact of the new crown epidemic and anti-repair incidents.However,Hong Kong’s marginalization is indeed somewhat inappropriate.As far as the situation is concerned,Hong Kong still has a strong competitiveness,although it is lagging behind,but Hong Kong should think deeply about the strategy and system of“one country,two systems”,believe in the country’s strategic intention and adjust its state in time to re-exclude the public’s understanding of its marginalization.展开更多
This article introduces a cable-driven lower limb rehabilitation robot with movable distal anchor points(M-CDLR).The traditional cable-driven parallel robots(CDPRs)control the moving platform by changing the length of...This article introduces a cable-driven lower limb rehabilitation robot with movable distal anchor points(M-CDLR).The traditional cable-driven parallel robots(CDPRs)control the moving platform by changing the length of cables,M-CDLR can also adjust the position of the distal anchor point when the moving platform moves.The M-CDLR this article proposed has gait and single-leg training modes,which correspond to the plane and space motion of the moving platform,respectively.After introducing the system structure configuration,the generalized kinematics and dynamics of M-CDLR are established.The fully constrained CDPRs can provide more stable rehabilitation training than the under-constrained one but requires more cables.Therefore,a motion planning method for the movable distal anchor point of M-CDLR is proposed to realize the theoretically fully constrained with fewer cables.Then the expected trajectory of the moving platform is obtained from the motion capture experiment,and the motion planning of M-CDLR under two training modes is simulated.The simulation results verify the effectiveness of the proposed motion planning method.This study serves as a basic theoretical study of the structure optimization and control strategy of M-CDLR.展开更多
We report a broadband two-dimensional(2 D) Kerr and Raman–Kerr frequency comb generation in a silica bottle resonator accounting for azimuthal and axial degrees of freedom and pioneer a method that allows for control...We report a broadband two-dimensional(2 D) Kerr and Raman–Kerr frequency comb generation in a silica bottle resonator accounting for azimuthal and axial degrees of freedom and pioneer a method that allows for controlled and reversible switching between a four wave mixing(FWM) state and a stimulated Raman scattering state. The repetition rate of the Raman–Kerr comb is not an integer number of the free spectral range, which spans more than 242 nm with hundreds of teeth. We show that, experimentally and numerically, multiple 2 D comb regimes can be selectively accessed via dispersion engineering by exciting different orders of axial modes or modifying the curvature of the axial profile, involving cascaded FWM, Raman lasing, and Raman-assisted FWM. The effect of axial curvature on dispersion is associated with the axial mode number in bottle resonators. Our approach enables dispersion and spectral engineering flexibility in any resonator with localized axial modes.展开更多
Microresonator-based optical frequency combs are broadband light sources consisting of equally spaced and coherent narrow lines,which are extremely promising for applications in molecular spectroscopy and sensing in t...Microresonator-based optical frequency combs are broadband light sources consisting of equally spaced and coherent narrow lines,which are extremely promising for applications in molecular spectroscopy and sensing in the mid-infrared(MIR)spectral region.There are still great challenges in exploring how to improve materials for microresonator fabrication,extend spectral bandwidth of parametric combs,and realize fully stabilized soliton MIR frequency combs.Here,we present an effective scheme for broadband MIR optical frequency comb generation in a MgF_(2) crystalline microresonator pumped by the quantum cascade laser.The spectral evolution dynamics of the MIR Kerr frequency comb is numerically investigated,revealing the formation mechanism of the microresonator soliton comb via scanning the pump-resonance detuning.We also experimentally implement the modulation instability state MIR frequency comb generation in MgF_(2) resonators covering from 3380 nm to 7760 nm.This work proceeds microresonator-based comb technology toward a miniaturization MIR spectroscopic device that provides potential opportunities in many fields such as fundamental physics and metrology.展开更多
文摘Under the background of new engineering,the reform of the comprehensive practical course system for mechanical and electronic engineering majors actively responds to the challenges posed by the new round of technological revolution and industrial transformation to higher education,cultivating top-notch innovative intellectuals with comprehensive engineering qualities,meeting the requirements of being able to solve complex engineering problems rather than just cognitive capabilities,forming two core courses through reconstructing and reshaping the core courses of the major.The core courses include Drive,Measurement,and Control I and Drive,Measurement,and Control II,which highlight the comprehensive framework of mechanical and electronic engineering professional knowledge,continuing the comprehensive practical course system based on the unity of knowledge and practice,following the trend of new engineering,highlighting the practicality of professional innovation,assisting engineering education reform,and promoting high-quality development of new engineering professionals cultivation.
基金financially supported by grants from Key Research and Development Projects of Zhejiang Province (2020C03071)the Construction Fund of Medical Key Disciplines of Hangzhou (OO20200485, OO20200055)。
文摘BACKGROUND:A20 may be a neuroprotective factor.Herein,we aimed to investigate whether serum A20 levels were associated with disease severity,delayed cerebral ischemia(DCI),and outcome after aneurysmal subarachnoid hemorrhage(aSAH).METHODS:In this prospective cohort study containing 112 aSAH patients and 112 controls,serum A20 levels were quantified.At 90 d poststroke,Modified Rankin Scale(MRS) scores≥3 were defined as a poor outcome.All correlations and associations were assessed using multivariate analysis.RESULTS:Compared with controls,there was a significant elevation of serum A20 levels in patients(median 123.7 pg/mL vs.25.8 pg/mL;P<0.001).Serum A20 levels were independently correlated with Hunt-Hess scores(β 9.854;95% confidence interval [95% CI] 2.481-17.227,P=0.009) and modified Fisher scores(β 10.349,95% CI 1.273-19.424,P=0.026).Independent associations were found between serum A20 levels and poor outcome(odds ratio [OR] 1.015,95%CI 1.000-1.031,P=0.047) and DCI(OR 1.018,95% CI 1.001-1.035,P=0.042).Areas under the curve for predicting poor outcome and DCI were 0.771(95% CI 0.682-0.845) and 0.777(95% CI 0.688-0.850),respectively.Serum A20 levels ≥128.15 pg/mL predicted poor outcome,with a sensitivity of 73.9% and specificity of 74.2%,and A20 levels ≥160.55 pg/mL distinguished the risk of DCI with65.5% sensitivity and 89.2% specificity.Its ability to predict poor outcome and DCI was similar to those of Hunt-Hess scores and modified Fisher scores(both P>0.05).CONCLUSION:Enhanced serum A20 levels are significantly associated with stroke severity and poor clinical outcome after aSAH,implying that serum A20 may be a potential prognostic biomarker for aSAH.
文摘With the arrival of the intelligence era of Industry 4.0,social development has shown complex and diversified characteristics,gradually forming an innovation ecological environment constructed by vertical interaction of multi-layer innovation systems and horizontal collaboration of multiple organizations and departments,which has posed extremely challenging requirements for higher engineering education to cultivate engineering talents with comprehensive engineering qualities who can solve complex engineering problems.However,practical engineering problems may involve a complex knowledge chain of interdisciplinary and multi-disciplinary cross-coupling.Therefore,higher engineering education needs to form a new interdisciplinary and multi-disciplinary integrated engineering innovation talent training system.Based on the characteristics of the mechanical and electronic engineering major,we will reshape and reconstruct the core courses of the mechanical and electronic engineering major.Two core courses are formed:Drive and Measurement and Control I and Drive and Measurement and Control II,with information flow and energy flow as the main lines,following up with the comprehensive practical curriculum system based on the unity of knowledge and practice and ability-oriented thinking,supporting teaching objectives,promoting students’individual development,and providing guidelines for relevant curriculum reforms.
文摘Using of diffractive optical elements (DOE) in the Schupmann system offer a new way for the construction of ultra-large aperture telescope. The Fresnel Corrector, one of the DOEs, is the key device in the Schupmann system, which is used to correct the chromatic aberration introduced by the diffractive primary lens called Magnifying Glass. Generally, in a large aperture telescope (>20 m), the Fresnel Corrector is a diffractive lens with a large aperture and a small f-number, which is difficult to process. In this article, an improved device with a small F number but a large rim feature size, called amplitude and phase hybrid modulation Fresnel diffractive optical element (APHMFDOE), is used here as the Fresnel corrector. First, APHMFDOE with appropriate parameters is designed to match the dispersion of the Magnifying Glass so that the system meets the achromatic condition. Second, the optical characteristics of this improved system are simulated and compared with those of the general system based on the conventional Fresnel corrector. Our approach introduces a new dispersion correction device, which not only can eliminate the chromatic aberration caused by Magnifying Glass, but also can reduce the processing difficulty of Fresnel Corrector.
文摘According to the GFCI ranking from 2018-2020,Hong Kong fell from third to sixth,surpassing cities in other Asian countries and some inland cities in China.Hong Kong’s marginalization has intensified because of the impact of the new crown epidemic and anti-repair incidents.However,Hong Kong’s marginalization is indeed somewhat inappropriate.As far as the situation is concerned,Hong Kong still has a strong competitiveness,although it is lagging behind,but Hong Kong should think deeply about the strategy and system of“one country,two systems”,believe in the country’s strategic intention and adjust its state in time to re-exclude the public’s understanding of its marginalization.
基金funded by the National Natural Science Foundation of China,Grant Number:52175006.
文摘This article introduces a cable-driven lower limb rehabilitation robot with movable distal anchor points(M-CDLR).The traditional cable-driven parallel robots(CDPRs)control the moving platform by changing the length of cables,M-CDLR can also adjust the position of the distal anchor point when the moving platform moves.The M-CDLR this article proposed has gait and single-leg training modes,which correspond to the plane and space motion of the moving platform,respectively.After introducing the system structure configuration,the generalized kinematics and dynamics of M-CDLR are established.The fully constrained CDPRs can provide more stable rehabilitation training than the under-constrained one but requires more cables.Therefore,a motion planning method for the movable distal anchor point of M-CDLR is proposed to realize the theoretically fully constrained with fewer cables.Then the expected trajectory of the moving platform is obtained from the motion capture experiment,and the motion planning of M-CDLR under two training modes is simulated.The simulation results verify the effectiveness of the proposed motion planning method.This study serves as a basic theoretical study of the structure optimization and control strategy of M-CDLR.
基金National Natural Science Foundation of China(62005071)Natural Science Foundation of Anhui Province(2008085QF312)+1 种基金Fundamental Research Funds for the Central Universities(JZ2019HGBZ0122,JZ2019H GTA0050)National Key Research and Development Program of China(2019YFE010747)。
文摘We report a broadband two-dimensional(2 D) Kerr and Raman–Kerr frequency comb generation in a silica bottle resonator accounting for azimuthal and axial degrees of freedom and pioneer a method that allows for controlled and reversible switching between a four wave mixing(FWM) state and a stimulated Raman scattering state. The repetition rate of the Raman–Kerr comb is not an integer number of the free spectral range, which spans more than 242 nm with hundreds of teeth. We show that, experimentally and numerically, multiple 2 D comb regimes can be selectively accessed via dispersion engineering by exciting different orders of axial modes or modifying the curvature of the axial profile, involving cascaded FWM, Raman lasing, and Raman-assisted FWM. The effect of axial curvature on dispersion is associated with the axial mode number in bottle resonators. Our approach enables dispersion and spectral engineering flexibility in any resonator with localized axial modes.
基金National Natural Science Foundation of China(61635013)Natural Science Basic Research Program of Shaanxi Province(2022JC-43)。
文摘Microresonator-based optical frequency combs are broadband light sources consisting of equally spaced and coherent narrow lines,which are extremely promising for applications in molecular spectroscopy and sensing in the mid-infrared(MIR)spectral region.There are still great challenges in exploring how to improve materials for microresonator fabrication,extend spectral bandwidth of parametric combs,and realize fully stabilized soliton MIR frequency combs.Here,we present an effective scheme for broadband MIR optical frequency comb generation in a MgF_(2) crystalline microresonator pumped by the quantum cascade laser.The spectral evolution dynamics of the MIR Kerr frequency comb is numerically investigated,revealing the formation mechanism of the microresonator soliton comb via scanning the pump-resonance detuning.We also experimentally implement the modulation instability state MIR frequency comb generation in MgF_(2) resonators covering from 3380 nm to 7760 nm.This work proceeds microresonator-based comb technology toward a miniaturization MIR spectroscopic device that provides potential opportunities in many fields such as fundamental physics and metrology.
