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图像重建及3D虚拟现实技术在经蝶垂体瘤手术中的应用 被引量:5
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作者 张锐 孟令雷 +2 位作者 孔世奇 李辉 霍贵通 《系统医学》 2018年第14期133-135,共3页
目的通过计算机软件的图像重建技术(3Dslicer,www.slicer.org),将术前CT,MRI断层扫描图像转换为3D虚拟可视图像,可用于模拟手术入路并了解蝶窦内解剖情况。方法选取2017年1月—2017年6月在邢台市人民医院神经外三科接受手术治疗的垂体... 目的通过计算机软件的图像重建技术(3Dslicer,www.slicer.org),将术前CT,MRI断层扫描图像转换为3D虚拟可视图像,可用于模拟手术入路并了解蝶窦内解剖情况。方法选取2017年1月—2017年6月在邢台市人民医院神经外三科接受手术治疗的垂体瘤患者6例,常规术前检查行垂体MRI平扫强化,蝶窦CT,获取图像文件后导入计算机,使用3Dslicr软件重建后,可得到蝶鞍区3D虚拟图像。结果 6例手术顺利,术中图像与术前3D重建图像基本一致,可以指导手术,避免手术方向的偏离,降低了大血管损伤的几率。结论通过术前图像重建以及3D虚拟现实技术的应用,可以在术前帮助医生更好的理解MRI,CT断层图像,熟悉蝶窦内解剖情况,避免手术路径偏航,降低了手术中颈动脉损伤的风险。 展开更多
关键词 图像重建 图像引导 内镜经鼻入路3Dslicer软件
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细菌纤维素覆膜硅油纸制备食品包装材料的研究 被引量:2
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作者 陈璇琪 徐雅玲 +4 位作者 胡歆笛 柳蕲津 孔世齐 王红霞 安润知 《浙江化工》 CAS 2022年第9期25-29,共5页
目的:研究一种培养薄膜细菌纤维素复合材料用作食品包装材料的可行性。方法:以涂布硅油纸为基体材料,通过添加木醋杆菌菌液培养基进行浅盘培养,可得到细菌纤维素薄膜制备覆膜材料。结果:细菌纤维素薄膜可和硅油纸紧密结合,覆膜细菌纤维... 目的:研究一种培养薄膜细菌纤维素复合材料用作食品包装材料的可行性。方法:以涂布硅油纸为基体材料,通过添加木醋杆菌菌液培养基进行浅盘培养,可得到细菌纤维素薄膜制备覆膜材料。结果:细菌纤维素薄膜可和硅油纸紧密结合,覆膜细菌纤维素产量随着培养基用量的增加而增加。添加浓度为5%的蒙脱土悬浮液,可得到最高细菌纤维素产量;添加浓度为8%的蒙脱土悬浮液,其阻水性能最好。结论:红茶培养基比传统常规培养基更能促进细菌纤维素的生产。在培养基中添加不同浓度的蒙脱土悬浮液可同时改善细菌纤维素产量、覆膜表面的耐水性能和复合材料的机械性能。 展开更多
关键词 细菌纤维素 覆膜复合材料 木醋杆菌 耐水性
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Targeting c-Myc on cell growth and vascular endothelial growth factor expression in IN500 glioblastoma cells 被引量:2
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作者 HU Yu-hua kong shi-qi +2 位作者 kong Hai-bo WU Jian-liang CHEN Ze 《Chinese Medical Journal》 SCIE CAS CSCD 2012年第11期2025-2031,共7页
Background The level of c-Myc is closely associated with high pathological grade and the poor prognosis of gliomas. Vascular endothelial growth factor (VEGF) is the most important angiogenic factor that potently sti... Background The level of c-Myc is closely associated with high pathological grade and the poor prognosis of gliomas. Vascular endothelial growth factor (VEGF) is the most important angiogenic factor that potently stimulates the proliferation and migration of vascular endothelial cells. This study aimed to address the biological importance of c-Myc in the development of gliomas, we downregulated the expression of c-Myc in the human glioblastoma cell line IN500 and studied the in vitro effect on cellular growth, proliferation, and apoptosis and the expression of VEGF and the in vivo effect on tumor formation in a xenograft mouse model. Methods IN500A cells were stably transfected with shRNA-expressing plasmids for either c-Myc (pCMYC-shRNA) or as a control (pCtrl-shRNA). Following establishment of stable cells, the mRNA expressions of c-Myc and VEGF were examined by reverse transcription (RT)-PCR, and c-Myc and VEGF proteins by Western blotting and immunohistochemistry. Cell-cycle progression and apoptosis were determined by flow cytometry. The in vivo effect of targeting c-Myc was determined by subcutaneous injection of stable cells into immunodeficient nude mice. Results The stable transfection of pCMYC-shRNA successfully knocked down the steady-state mRNA and protein levels of c-Myc in IN500, which positively correlated with the downregulation of VEGF. Downregulating c-Myc in vitro also led to G1-S arrest and enhanced apoptosis. In vivo, targeting c-Myc reduced xenograft tumor formation and resulted in significantly smaller tumors. Conclusions c-Myc has multiple functions in glioblastoma development that include regulating cell-cycle, apoptosis, and VEGF expression. Targeting c-Myc expression may be a promising therapy for malignant glioma. 展开更多
关键词 C-MYC RNA interference IN5OOA cells cell proliferation apoptosis vascular endothelial growth factor GLIOMA
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