Objective To investigate the effects of buccal acupuncture on analgesia,immune indicators,and expression levels of Survivin and Livin proteins in patients with advanced-stage primary liver cancer.Methods Eighty patien...Objective To investigate the effects of buccal acupuncture on analgesia,immune indicators,and expression levels of Survivin and Livin proteins in patients with advanced-stage primary liver cancer.Methods Eighty patients with advanced-stage primary liver cancer were selected and divided into control and treatment groups according to the difference in treatment modalities,with 40 patients in each group.The control group received transcatheter arterial chemoembolization(TACE),and the treatment group received buccal acupuncture in addition to TACE.The recent efficacy,analgesic effect,liver function,serum tumor markers,Survivin and Livin protein expression levels in liver cancer tissue,and immune indexes were analyzed and compared between the two groups.Results The objective response rate(ORR)and disease control rate(DCR)of the treatment group were 37.5%and 77.5%,respectively,which were significantly higher than those of the control group(22.5%and 52.5%),and the recent efficacy of the treatment group was significantly better than that of the control group(P<0.05).The onset of analgesia in the treatment group was significantly faster than that in the control group(P<0.05),the duration of analgesia was significantly longer than that in the control group(P<0.05),and the numeric rating scale(NRS)score of pain after treatment was significantly lower than that in the control group(P<0.05).In the treatment group,the aspartate aminotransferase(AST),alanine aminotransferase(ALT),and albumin/globulin(A/G)were significantly lower than those in the control group(P<0.05),and the serum levels of alpha-fetoprotein(AFP),alpha-L-fucosidase(AFU),and carcinoembryonic antigen(CEA)were significantly lower than those in the control group(P<0.05),and the expression levels of Survivin and Livin in liver cancer tissue were significantly lower than those in the control group(P<0.05);CD4^(+)and CD4^(+)/CD8+in the treatment group were significantly higher than those in the control group,and CD8+was significantly lower than that in the control group after treatment(P<0.05).Conclusion Buccal acupuncture can reduce the degree of pain and liver function damage in patients with advanced-stage primary liver cancer and lower the serum tumor marker levels,and its mechanism of action may be related to the down-regulation of Survivin and Livin protein expression levels in the liver cancer tissue and the regulation of the immune function.展开更多
Objective:To observe the clinical efficacy of electroacupuncture(EA)in controlling myopia in children and its effect on retinal blood flow.Methods:Sixty-eight myopic children were randomly divided into an observation ...Objective:To observe the clinical efficacy of electroacupuncture(EA)in controlling myopia in children and its effect on retinal blood flow.Methods:Sixty-eight myopic children were randomly divided into an observation group and a control group,with 34 cases in each group.The control group was given auricular acupressure treatment alone,and the observation group was treated with EA once a week in addition to the treatment used in the control group.The spherical equivalent refraction(SER)and axial length(AL)were measured at baseline,and after 3 months and 6 months of treatment.Optical coherence tomography angiography was used to measure the vessel density(VD)and perfusion density(PD)in the surface layer of the retina.Results:After 3 months and 6 months of treatment,the changes in SER between the two groups were not statistically significant(P>0.05).After 3 months of treatment,the changes in AL between the two groups were not statistically significant(P>0.05);after 6 months of treatment,the change amount of AL in the observation group was smaller than that in the control group(P<0.05);after 3 months and 6 months of treatment,the changes in VD and PD in the surface layer of the retina in the observation group were significantly greater than those in the control group(P<0.01).Conclusion:EA treatment once a week for 6 months can delay the increase of AL and improve the retinal surface blood flow in myopic children.展开更多
Objective:To evaluate the therapeutic efficacy of acupuncture plus Dang Gui Bu Xue Qu Feng Tang for benign essential blepharospasm(BEB).Methods:A prospective randomized controlled trial was performed.A total of 105 pa...Objective:To evaluate the therapeutic efficacy of acupuncture plus Dang Gui Bu Xue Qu Feng Tang for benign essential blepharospasm(BEB).Methods:A prospective randomized controlled trial was performed.A total of 105 participants were randomized 1:1:1 into an acupuncture group,a herbal medicine group and an acupuncture plus herbal medicine group.Participants in the acupuncture group received manual acupuncture treatment,twice a week.Participants in the herbal medicine group received Dang Gui Bu Xue Qu Feng Tang,oral administration,once a day.Participants in the acupuncture plus herbal medicine group received both treatments.The therapeutic effects of the three groups were evaluated after four weeks of treatment.The primary outcome was the Jankovic rating scale(JRS)score,and the secondary outcome was the blepharospasm disability index(BSDI)score.Results:After four weeks of treatment,the JRS total scores significantly decreased in all three groups versus baseline(P<0.05).A greater reduction in the JRS total score was reported in participants in the acupuncture plus herbal medicine group(P<0.05),but there was no significant difference between the acupuncture group and the herbal medicine group(P>0.05).The acupuncture plus herbal medicine group had a greater decrease in the JRS severity score than the herbal medicine group(P<0.05).The reduction in the JRS frequency score was not significantly different among the three groups(P>0.05).The BSDI scores significantly decreased in all three groups versus baseline(P<0.05),but the reduction in the BSDI score was insignificantly different among the three groups(P>0.05).Conclusion:It is effective in the treatment of BEB either to use acupuncture and Dang Gui Bu Xue Qu Feng Tang alone or in combination.The combination therapy shows a more significant effect than either of the treatment alone.展开更多
Objective:To observe the safety of the Song-Relaxing and Zhen-Vibrating abdomen manipulation in treating patients with prediabetes and its effects on blood glucose and lipid metabolism.Methods:One hundred and two pati...Objective:To observe the safety of the Song-Relaxing and Zhen-Vibrating abdomen manipulation in treating patients with prediabetes and its effects on blood glucose and lipid metabolism.Methods:One hundred and two patients with prediabetes were divided into a manipulation group and a control group according to the random number table method,with 51 cases in each group.All patients received the general behavioral intervention for prediabetes,with additional Song-Relaxing and Zhen-Vibrating abdomen manipulation in the manipulation group and oral metformin hydrochloride tablets in the control group.Both groups received the intervention for six months.Results:Fourteen patients dropped out during the treatment,and a total of 88 patients completed the trial,including 45 cases in the manipulation group and 43 cases in the control group.After the treatment,the prediabetes control rate was 93.3%in the manipulation group and 74.4%in the control group,and the difference between the two groups was statistically significant(P<0.05);no patient in the manipulation group progressed to diabetes,while the rate of conversion to diabetes in the control group was 6.9%,with a significant difference between the two groups(P<0.05).After the treatment,the body mass index(BMI),glycosylated hemoglobin A1c(HbA1c),fasting plasma glucose(FPG),2-hour postload plasma glucose(2hPG)level during an oral glucose tolerance test(OGTT),fasting insulin(FINS),homeostasis model assessment-2 of insulin resistance(HOMA2-IR),total cholesterol(TC),and triglycerides(TG)decreased in both groups versus baseline,with significant differences within the groups;the levels of all indicators were lower in the manipulation group than in the control group(P<0.05),and the differences between the two groups were more prominent at the sixth month(P<0.01).At the sixth month,the high-density lipoprotein cholesterol(HDL-C)in the manipulation group was increased,while there was no significant change in the control group.In the control group,three patients reported mild gastrointestinal reactions at the initial dosing,which improved after medication adjustment.No other adverse events were observed in either group.Conclusion:Both metformin hydrochloride tablets and the Song-Relaxing and Zhen-Vibrating abdomen manipulation can improve blood glucose and lipid metabolism and reduce insulin resistance and clinical discomfort in patients with prediabetes,but the Song-Relaxing and Zhen-Vibrating abdomen manipulation has higher efficacy and safety.展开更多
Objective To observe the efficacy of mild moxibustion combined with arthroscopic meniscal repair in the treatment of meniscal injury and to explore its action mechanism.Methods Ninety-eight patients with meniscal inju...Objective To observe the efficacy of mild moxibustion combined with arthroscopic meniscal repair in the treatment of meniscal injury and to explore its action mechanism.Methods Ninety-eight patients with meniscal injury were divided into a surgery group and a moxibustion plus surgery group by the random number table method,with 49 cases in each group.Both groups received arthroscopic meniscal repair,and the moxibustion plus surgery group was treated with add-on mild moxibustion.The Lysholm score,visual analog scale(VAS)score,and mobility of the affected knee were measured before and after treatment,and transforming growth factor(TGF)-β1 and platelet-derived growth factor(PDGF)levels were measured in the fluid of the affected knee joint.The healing of the meniscus was recorded at a follow-up visit 3 months after the surgery.Results After treatment,the Lysholm score increased,the VAS score decreased in both groups,and the intra-group differences in both groups were statistically significant(P<0.05).The Lysholm score was higher in the moxibustion plus surgery group than in the surgery group,and the VAS score was lower in the moxibustion plus surgery group than in the surgery group.The differences between groups in both scores were statistically significant(P<0.05).The mobility of the affected knee joint increased in both groups(P<0.05),and it was greater in the moxibustion plus surgery group than in the surgery group(P<0.05).When compared with pretreatment,the levels of TGF-β1 and PDGF in the fluid of the knee joint increased in both groups(P<0.05),and the levels of TGF-β1 and PDGF in the fluid of the affected knee joint were higher in the moxibustion plus surgery group than in the surgery group(P<0.05).The healing of the meniscus in the moxibustion plus surgery group was significantly better than that in the surgery group at the follow-up visit 3 months after the surgery(P<0.05).Conclusion The effect of mild moxibustion combined with arthroscopic meniscal repair is better than the surgery alone in improving knee function,relieving pain,increasing mobility of the affected knee,and promoting meniscal healing,which may be related to the up-regulation of TGF-β1 and PDGF levels in the fluid of knee joint.展开更多
文摘Objective To investigate the effects of buccal acupuncture on analgesia,immune indicators,and expression levels of Survivin and Livin proteins in patients with advanced-stage primary liver cancer.Methods Eighty patients with advanced-stage primary liver cancer were selected and divided into control and treatment groups according to the difference in treatment modalities,with 40 patients in each group.The control group received transcatheter arterial chemoembolization(TACE),and the treatment group received buccal acupuncture in addition to TACE.The recent efficacy,analgesic effect,liver function,serum tumor markers,Survivin and Livin protein expression levels in liver cancer tissue,and immune indexes were analyzed and compared between the two groups.Results The objective response rate(ORR)and disease control rate(DCR)of the treatment group were 37.5%and 77.5%,respectively,which were significantly higher than those of the control group(22.5%and 52.5%),and the recent efficacy of the treatment group was significantly better than that of the control group(P<0.05).The onset of analgesia in the treatment group was significantly faster than that in the control group(P<0.05),the duration of analgesia was significantly longer than that in the control group(P<0.05),and the numeric rating scale(NRS)score of pain after treatment was significantly lower than that in the control group(P<0.05).In the treatment group,the aspartate aminotransferase(AST),alanine aminotransferase(ALT),and albumin/globulin(A/G)were significantly lower than those in the control group(P<0.05),and the serum levels of alpha-fetoprotein(AFP),alpha-L-fucosidase(AFU),and carcinoembryonic antigen(CEA)were significantly lower than those in the control group(P<0.05),and the expression levels of Survivin and Livin in liver cancer tissue were significantly lower than those in the control group(P<0.05);CD4^(+)and CD4^(+)/CD8+in the treatment group were significantly higher than those in the control group,and CD8+was significantly lower than that in the control group after treatment(P<0.05).Conclusion Buccal acupuncture can reduce the degree of pain and liver function damage in patients with advanced-stage primary liver cancer and lower the serum tumor marker levels,and its mechanism of action may be related to the down-regulation of Survivin and Livin protein expression levels in the liver cancer tissue and the regulation of the immune function.
文摘Objective:To observe the clinical efficacy of electroacupuncture(EA)in controlling myopia in children and its effect on retinal blood flow.Methods:Sixty-eight myopic children were randomly divided into an observation group and a control group,with 34 cases in each group.The control group was given auricular acupressure treatment alone,and the observation group was treated with EA once a week in addition to the treatment used in the control group.The spherical equivalent refraction(SER)and axial length(AL)were measured at baseline,and after 3 months and 6 months of treatment.Optical coherence tomography angiography was used to measure the vessel density(VD)and perfusion density(PD)in the surface layer of the retina.Results:After 3 months and 6 months of treatment,the changes in SER between the two groups were not statistically significant(P>0.05).After 3 months of treatment,the changes in AL between the two groups were not statistically significant(P>0.05);after 6 months of treatment,the change amount of AL in the observation group was smaller than that in the control group(P<0.05);after 3 months and 6 months of treatment,the changes in VD and PD in the surface layer of the retina in the observation group were significantly greater than those in the control group(P<0.01).Conclusion:EA treatment once a week for 6 months can delay the increase of AL and improve the retinal surface blood flow in myopic children.
文摘Objective:To evaluate the therapeutic efficacy of acupuncture plus Dang Gui Bu Xue Qu Feng Tang for benign essential blepharospasm(BEB).Methods:A prospective randomized controlled trial was performed.A total of 105 participants were randomized 1:1:1 into an acupuncture group,a herbal medicine group and an acupuncture plus herbal medicine group.Participants in the acupuncture group received manual acupuncture treatment,twice a week.Participants in the herbal medicine group received Dang Gui Bu Xue Qu Feng Tang,oral administration,once a day.Participants in the acupuncture plus herbal medicine group received both treatments.The therapeutic effects of the three groups were evaluated after four weeks of treatment.The primary outcome was the Jankovic rating scale(JRS)score,and the secondary outcome was the blepharospasm disability index(BSDI)score.Results:After four weeks of treatment,the JRS total scores significantly decreased in all three groups versus baseline(P<0.05).A greater reduction in the JRS total score was reported in participants in the acupuncture plus herbal medicine group(P<0.05),but there was no significant difference between the acupuncture group and the herbal medicine group(P>0.05).The acupuncture plus herbal medicine group had a greater decrease in the JRS severity score than the herbal medicine group(P<0.05).The reduction in the JRS frequency score was not significantly different among the three groups(P>0.05).The BSDI scores significantly decreased in all three groups versus baseline(P<0.05),but the reduction in the BSDI score was insignificantly different among the three groups(P>0.05).Conclusion:It is effective in the treatment of BEB either to use acupuncture and Dang Gui Bu Xue Qu Feng Tang alone or in combination.The combination therapy shows a more significant effect than either of the treatment alone.
文摘Objective:To observe the safety of the Song-Relaxing and Zhen-Vibrating abdomen manipulation in treating patients with prediabetes and its effects on blood glucose and lipid metabolism.Methods:One hundred and two patients with prediabetes were divided into a manipulation group and a control group according to the random number table method,with 51 cases in each group.All patients received the general behavioral intervention for prediabetes,with additional Song-Relaxing and Zhen-Vibrating abdomen manipulation in the manipulation group and oral metformin hydrochloride tablets in the control group.Both groups received the intervention for six months.Results:Fourteen patients dropped out during the treatment,and a total of 88 patients completed the trial,including 45 cases in the manipulation group and 43 cases in the control group.After the treatment,the prediabetes control rate was 93.3%in the manipulation group and 74.4%in the control group,and the difference between the two groups was statistically significant(P<0.05);no patient in the manipulation group progressed to diabetes,while the rate of conversion to diabetes in the control group was 6.9%,with a significant difference between the two groups(P<0.05).After the treatment,the body mass index(BMI),glycosylated hemoglobin A1c(HbA1c),fasting plasma glucose(FPG),2-hour postload plasma glucose(2hPG)level during an oral glucose tolerance test(OGTT),fasting insulin(FINS),homeostasis model assessment-2 of insulin resistance(HOMA2-IR),total cholesterol(TC),and triglycerides(TG)decreased in both groups versus baseline,with significant differences within the groups;the levels of all indicators were lower in the manipulation group than in the control group(P<0.05),and the differences between the two groups were more prominent at the sixth month(P<0.01).At the sixth month,the high-density lipoprotein cholesterol(HDL-C)in the manipulation group was increased,while there was no significant change in the control group.In the control group,three patients reported mild gastrointestinal reactions at the initial dosing,which improved after medication adjustment.No other adverse events were observed in either group.Conclusion:Both metformin hydrochloride tablets and the Song-Relaxing and Zhen-Vibrating abdomen manipulation can improve blood glucose and lipid metabolism and reduce insulin resistance and clinical discomfort in patients with prediabetes,but the Song-Relaxing and Zhen-Vibrating abdomen manipulation has higher efficacy and safety.
文摘Objective To observe the efficacy of mild moxibustion combined with arthroscopic meniscal repair in the treatment of meniscal injury and to explore its action mechanism.Methods Ninety-eight patients with meniscal injury were divided into a surgery group and a moxibustion plus surgery group by the random number table method,with 49 cases in each group.Both groups received arthroscopic meniscal repair,and the moxibustion plus surgery group was treated with add-on mild moxibustion.The Lysholm score,visual analog scale(VAS)score,and mobility of the affected knee were measured before and after treatment,and transforming growth factor(TGF)-β1 and platelet-derived growth factor(PDGF)levels were measured in the fluid of the affected knee joint.The healing of the meniscus was recorded at a follow-up visit 3 months after the surgery.Results After treatment,the Lysholm score increased,the VAS score decreased in both groups,and the intra-group differences in both groups were statistically significant(P<0.05).The Lysholm score was higher in the moxibustion plus surgery group than in the surgery group,and the VAS score was lower in the moxibustion plus surgery group than in the surgery group.The differences between groups in both scores were statistically significant(P<0.05).The mobility of the affected knee joint increased in both groups(P<0.05),and it was greater in the moxibustion plus surgery group than in the surgery group(P<0.05).When compared with pretreatment,the levels of TGF-β1 and PDGF in the fluid of the knee joint increased in both groups(P<0.05),and the levels of TGF-β1 and PDGF in the fluid of the affected knee joint were higher in the moxibustion plus surgery group than in the surgery group(P<0.05).The healing of the meniscus in the moxibustion plus surgery group was significantly better than that in the surgery group at the follow-up visit 3 months after the surgery(P<0.05).Conclusion The effect of mild moxibustion combined with arthroscopic meniscal repair is better than the surgery alone in improving knee function,relieving pain,increasing mobility of the affected knee,and promoting meniscal healing,which may be related to the up-regulation of TGF-β1 and PDGF levels in the fluid of knee joint.
