A new cobalt complex with flavonoid carboxylate ligand was synthesized and characterized. X-ray diffraction data revealed that the compound crystallizes in the monoclinic crystal system, space group P2_1/c with a = 7....A new cobalt complex with flavonoid carboxylate ligand was synthesized and characterized. X-ray diffraction data revealed that the compound crystallizes in the monoclinic crystal system, space group P2_1/c with a = 7.936(3), b = 21.475(7), c = 20.010(7) ?, β = 102.856(14)o, V = 3325(2) ?~3, Z = 4, C_(34)H_(32)CoO_(15), M_r = 739.53, D_c = 1.477 g/cm^3, F(000) = 1532, μ = 0.591 mm^(-1), R = 0.1123 and w R = 0.1419. In the crystal structure, the Co(Ⅱ) shows 6 coordination geometry, and the flavonoid ligand coordinated with the Co(Ⅱ) ion in a monodentate mode. Hydrogen bonding interactions and π-π stacking interactions lead to the three-dimensional stacking of crystal and increase its stability. Moreover, the thermal stability and luminescent properties of the complex are also investigated. The fluorescence of the complex shows a great reduction of the intensity than that of the ligand.展开更多
CD47是一种免疫球蛋白,在多种癌细胞表面过表达。CD47与信号调节蛋白α(signal regulatory protein alpha,SIRPα)形成信号复合物,促使癌细胞从巨噬细胞介导的吞噬作用中逃逸。近年来,CD47已被证明在多种类型的实体肿瘤中高表达,并与患...CD47是一种免疫球蛋白,在多种癌细胞表面过表达。CD47与信号调节蛋白α(signal regulatory protein alpha,SIRPα)形成信号复合物,促使癌细胞从巨噬细胞介导的吞噬作用中逃逸。近年来,CD47已被证明在多种类型的实体肿瘤中高表达,并与患者的不良预后相关。越来越多的研究表明,抑制CD47-SIRPα信号通路可促进适应性免疫反应,增强巨噬细胞对肿瘤细胞的吞噬作用。人源化抗CD47 IgG4单克隆抗体已进入临床试验,用于多种进展期实体瘤和淋巴瘤的治疗,显示出其安全性并在部分患者中取得部分缓解的疗效。本综述描述了CD47的结构和功能以及肿瘤中调控CD47的机制,概述了靶向CD47的治疗性抗体药物的研究进展与其靶向药物较易发生严重不良反应的研究瓶颈,并评估了靶向CD47-SIRPα信号通路在抗癌治疗中的潜力。展开更多
基金supported by the National Natural Science Foundation of China(No.21173074)
文摘A new cobalt complex with flavonoid carboxylate ligand was synthesized and characterized. X-ray diffraction data revealed that the compound crystallizes in the monoclinic crystal system, space group P2_1/c with a = 7.936(3), b = 21.475(7), c = 20.010(7) ?, β = 102.856(14)o, V = 3325(2) ?~3, Z = 4, C_(34)H_(32)CoO_(15), M_r = 739.53, D_c = 1.477 g/cm^3, F(000) = 1532, μ = 0.591 mm^(-1), R = 0.1123 and w R = 0.1419. In the crystal structure, the Co(Ⅱ) shows 6 coordination geometry, and the flavonoid ligand coordinated with the Co(Ⅱ) ion in a monodentate mode. Hydrogen bonding interactions and π-π stacking interactions lead to the three-dimensional stacking of crystal and increase its stability. Moreover, the thermal stability and luminescent properties of the complex are also investigated. The fluorescence of the complex shows a great reduction of the intensity than that of the ligand.
文摘CD47是一种免疫球蛋白,在多种癌细胞表面过表达。CD47与信号调节蛋白α(signal regulatory protein alpha,SIRPα)形成信号复合物,促使癌细胞从巨噬细胞介导的吞噬作用中逃逸。近年来,CD47已被证明在多种类型的实体肿瘤中高表达,并与患者的不良预后相关。越来越多的研究表明,抑制CD47-SIRPα信号通路可促进适应性免疫反应,增强巨噬细胞对肿瘤细胞的吞噬作用。人源化抗CD47 IgG4单克隆抗体已进入临床试验,用于多种进展期实体瘤和淋巴瘤的治疗,显示出其安全性并在部分患者中取得部分缓解的疗效。本综述描述了CD47的结构和功能以及肿瘤中调控CD47的机制,概述了靶向CD47的治疗性抗体药物的研究进展与其靶向药物较易发生严重不良反应的研究瓶颈,并评估了靶向CD47-SIRPα信号通路在抗癌治疗中的潜力。
