Relationship between contrast sensitivity and corneal shape following overnight orthokeratology

AIM: To evaluate the relationship between contrast sensitivity(CS) and corneal shape following overnight orthokeratology(OK). METHODS: We conducted a retrospective clinical study of 80 lens-wearing myopia patients, all of whom had undergone OK and had been evaluated by Orbscan II topography. We measured the surface irregularity index(SIRI) of corneal topography at 3 and 5 mm, the size of the flattened central corneal curvature of OK lens(zone A), the size of the cornea altered by OK lens(zone B), the size of the pupillary area at the corneal level(zone C), the area of crossover between zones A and C(zone AC), the area of crossover between zones B and C(BC), the ratio of BC to B(BC/B), and the ratio of AC to C(AC/C). CS was evaluated using the CSV-1000 with spatial frequencies of 3, 6, 12, and 18 cycles/degree(CPD). RESULTS: Multiple correlation analyses indicated significant negative correlations between CS, zone C, BC/B, and 3-mm SIRI(all P<0.01). There were no significant differences between CS, zone B, AC/A, or 5-mm SIRI(P=0.60, 0.94 and 0.11, respectively). Zone C was negatively correlated with 3, 6, 12, and 18 CPD. 5-mm SIRI were negatively correlated with 6, 12, and 18 CPD. BC/C was negatively correlated with 6 and 18 CPD. AC/C was positively correlated with 3 CPD. CONCLUSION: Zone C, 3-mm SIRI and BC/B affect the CS following overnight OK.

Change in foveal position based on age and axial length in high myopic eyes

AIM：To evaluate the influence of age and axial length（AL） on the position of the fovea in patients with high myopia（HM）.METHODS：In this prospective study,96 patients（186 eyes） with HM were consecutively recruited from the Third Affiliated Hospital of Nanchang University.DRI-OCT Atlantis,fundus imaging,and IOL Master were used in this study.Three indices were measured：the distance between the fovea and the optic nerve head（ONH） center（DFO）,the vertical distance between the fovea and the horizontal line pass of the ONH center（VDFO）,and the horizontal distance between the fovea and the vertical line pass of the ONH center（HDFO）.These measurements were used to analyze the effects of different age groups（A1,A2,A3 groups） and AL（AL1,AL2,AL3,AL4 groups） on these indices.RESULTS：The results showed that there was no statistical significance in DFO among the age and AL groups（F=0.46,0.37;P=0.62,0.76,respectively）.In HDFO,there was also no statistical significance among the age and AL groups（F=0.10,0.48;P=0.90,0.69,respectively）.In VDFO,however,the difference in the age and AL groups was statistically significant（F=3.21,3.12;P=0.04,0.02,respectively）.Thus,VDFO were correlated with age and AL（r=0.21,0.23,all P〈0.01）,while HDFO and DFO were not correlated with age and AL（r=0.30,P〉0.05）.CONCLUSION：In high myopia,the foveal position changes mainly in the vertical direction along with factors of age and AL.