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Screening and Identifying of Interaction Protein AtL5 in Arabidopsis thaliana
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作者 Jianzhong Huang Xiaoju Zhong +6 位作者 Xiuying Guan Peng Jia Hongbin Zhang kai chen Zhuojun Li Guangyu chen Chuitang Zeng 《Journal of Biosciences and Medicines》 2024年第7期184-193,共10页
Research background: The Arabidopsis-resistance protein L5 (AT1G12290) can trigger cell death in Nicotiana benthamiana, which is a characteristic function of an NBS-LRR (Nucleotide-Binding Sites and Leucine-Rich Repea... Research background: The Arabidopsis-resistance protein L5 (AT1G12290) can trigger cell death in Nicotiana benthamiana, which is a characteristic function of an NBS-LRR (Nucleotide-Binding Sites and Leucine-Rich Repeat) protein activation. Purpose: To explore the function and molecular regulatory network of L5. Method: We employed yeast two-hybrid technology to search for interacting proteins of L5, combined with laser confocal microscopy to observe the subcellular localization of these candidate proteins, and analyzed the impact of these proteins on L5 function using an Agrobacterium mediated transient expression system. Results: Seven candidate interacting proteins were identified from the Arabidopsis cDNA library, including PPA1 (AT1G01050), RIN4 (AT3G25070), LSU1 (AT3G49580), BZIP24 (AT3G51960), BOI (AT4G19700), RING/U (AT4G22250) and PPA3 (AT2G46860). Functional analysis of these candidate interacting proteins showed that they participated in multiple pathways, including biological and abiotic stress, programmed cell death, protein degradation, material metabolism and transcriptional regulation. The results of laser confocal microscopy manifested that RIN4 was only localized on the plasma membrane (PM), and RING/U was mainly associated with the PM. PPA1, PPA3, LSU1, BZIP24, and BOI all emerged nuclear and cytoplasmic localization. The results of the transient assay proclaimed that both BOI and RING/U can inhibit cell death caused by L5. Conclusions: These results indicate that L5 immune receptors may participate in various pathways, and their protein levels and activities are strictly regulated at multiple levels, providing a basis for elucidating the mechanism of L5 immune receptors in Arabidopsis resistance. 展开更多
关键词 Cell Death NBS-LRR Nicotiana benthamiana Yeast Two-Hybrid
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Dissecting Multiple Arabidopsis CC-NBS-LRR Proteins Structure and Localization
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作者 Jianzhong Huang Xiuying Guan +6 位作者 Xiaoju Zhong Peng Jia Hongbin Zhang kai chen Zhuojun Li Guangyu chen Chuitang Zeng 《Journal of Biosciences and Medicines》 2024年第7期87-99,共13页
NBS-LRR (nucleotide binding sites and leucine rich repeat) protein plays a crucial role as sentries and as defense activators in plants. The structure and function of NBS-LRR proteins are closely related. Previous art... NBS-LRR (nucleotide binding sites and leucine rich repeat) protein plays a crucial role as sentries and as defense activators in plants. The structure and function of NBS-LRR proteins are closely related. Previous articles have announced that the activated ZAR1 (HopZ-Activated Resistance 1) forms a pentamer in the plasma membrane, which is a calcium permeable channel that can trigger plant immune signaling and cell death. However, the structure of galore NBS-LRRs in Arabidopsis is not yet clear. The functional sites of distinct NBS-LRR in cells may vary. In addition, identifying pathogens and activating defense regions may occur in different subcellular compartments. Therefore, dissecting the specific structure and positioning of NBS-LRRs is an indispensable step in understanding their functions. In this article, we exploit AlphaFold to predict the structure of some designed NBS-LRRs, and utilize Agroinfiltration transient expression system, combined with biochemical fractionation, to dissect the localization of these NBS-LRR receptors from Arabidopsis. Structural data indicates that the identified NBS-LRRs share analogous conformation. Membrane fractionation assay demonstrates these NBS-LRRs are mainly associated with the membrane. These data show that the Ca2+-permeable channel activity may be evolutionarily conserved in NBS-LRR of Arabidopsis, and this study provides some reference clues for analyzing the structure and localization patterns of other plant immune receptors. 展开更多
关键词 ARABIDOPSIS Calcium Permeation Channel PENTAMER Plasma Membrane
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三种同分异构的双苯并吩噻嗪材料的合成、理论计算及光物理性质
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作者 王鹤然 陈凯 +5 位作者 伏硕 王晧暄 袁加轩 胡星奕 许文娟 密保秀 《物理化学学报》 SCIE CAS CSCD 北大核心 2024年第1期48-56,共9页
吩噻嗪及其衍生物材料是一类重要的多环芳烃材料,在光电子领域有着广泛的应用。其中,基于苯并噻嗪材料的研究相对较少。在本文中,我们分别在吩噻嗪的1,2-、2,3-和3,4-位引入苯基,制备了三种同分异构的双苯并吩噻嗪化合物D-PTZa、D-PTZb... 吩噻嗪及其衍生物材料是一类重要的多环芳烃材料,在光电子领域有着广泛的应用。其中,基于苯并噻嗪材料的研究相对较少。在本文中,我们分别在吩噻嗪的1,2-、2,3-和3,4-位引入苯基,制备了三种同分异构的双苯并吩噻嗪化合物D-PTZa、D-PTZb和D-PTZc,研究了它们的构效关系,并与双吩噻嗪化合物(D-PTZ)进行了对比。研究发现,D-PTZb和D-PTZc的HOMO和LUMO分布与D-PTZ的类似;对于D-PTZa,其1,2-位引入的苯基与中间的苯环空间张力较大,造成空间结构极度扭曲,性质比较特殊。并苯的引入可以有效增加分子的共轭长度,使得最大吸收波长发生红移;在2,3-位引入苯基可以有效地稳定HOMO能级,使基于π→π*跃迁的能隙稍有增大,呈现蓝光发射,溶液的荧光量子产率为1.7%;而在3,4-位引入苯基使LUMO分布更加趋向于线型,从而使LUMO更加稳定,使基于π→π*跃迁的能隙降低,其最大发射峰位于520 nm处,呈现黄绿光发射,溶液荧光量子产率为13%。此外并入苯环之后,空间张力增大,化合物的分解温度降低。我们的分子设计和结构–性质关系的研究可以为设计新的吩噻嗪材料提供基础指导。 展开更多
关键词 苯并吩噻嗪 有机光电材料 密度泛函理论 空穴-电子分析 前线轨道分布 光物理性质
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高性能锂离子电池用N掺杂C-Sn交联纳米纤维自支撑电极的理性设计 被引量:1
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作者 李莹 赵钰燊 +3 位作者 陈凯 刘旭 伊廷锋 陈立锋 《物理化学学报》 SCIE CAS CSCD 北大核心 2024年第3期33-43,共11页
为了提高碳材料作为锂离子电池负极材料的比容量,将氮掺杂的碳纤维与高容量的Sn进行复合。通过静电纺丝及低温碳化制备了均匀镶嵌Sn纳米颗粒的氮掺杂碳纳米纤维(C-Sn)复合膜。该复合膜直接用作自支撑锂离子电池负极时表现出较好的电化... 为了提高碳材料作为锂离子电池负极材料的比容量,将氮掺杂的碳纤维与高容量的Sn进行复合。通过静电纺丝及低温碳化制备了均匀镶嵌Sn纳米颗粒的氮掺杂碳纳米纤维(C-Sn)复合膜。该复合膜直接用作自支撑锂离子电池负极时表现出较好的电化学性能,Sn的引入显著提高了碳纳米纤维膜的电化学性能。碳均匀包覆Sn后形成的纤维结构可以促进离子电子的传导,并能有效缓冲Sn纳米粒子在循环过程中的体积变化,从而有效抑制粉化与团聚。Sn含量约为25.6%的CSn-2电极具有最高的比容量和更优异的倍率性能。电化学测试结果表明,在2A·g^(-1)的电流密度下,充放电循环1000圈后充电(放电)比容量为412.7(413.5)mAh·g^(-1)。密度泛函理论(DFT)计算结果表明,N掺杂非晶碳与锂具有良好的亲和性,有利于将合金化反应之后形成的SnxLiy合金锚定在碳表面,进而缓解了充放电过程中的Sn的体积变化。本文为高性能储锂材料的设计提供了一种切实可行的策略。 展开更多
关键词 自支撑电极 碳纤维 金属锡 锂离子电池 循环稳定性
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A Single-Board Integrated Millimeter-Wave Asymmetric Full-Digital Beamforming Array for B5G/6G Applications
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作者 Qingqing Lin Jun Xu +9 位作者 kai chen Long Wang Wei Li Zhiqiang Yu Guangqi Yang Jianyi Zhou Zhe chen Jixin chen Xiaowei Zhu Wei Hong 《Engineering》 SCIE EI CAS CSCD 2024年第10期35-50,共16页
In this article,a single-board integrated millimeter-wave(mm-Wave)asymmetric full-digital beamforming(AFDBF)array is developed for beyond-fifth-generation(B5G)and sixth-generation(6G)communications.The proposed integr... In this article,a single-board integrated millimeter-wave(mm-Wave)asymmetric full-digital beamforming(AFDBF)array is developed for beyond-fifth-generation(B5G)and sixth-generation(6G)communications.The proposed integrated array effectively addresses the challenge of arranging a large number of ports in a full-digital array by designing vertical connections in a three-dimensional space and successfully integrating full-digital transmitting(Tx)and receiving(Rx)arrays independently in a single board.Unlike the traditional symmetric array,the proposed asymmetric array is composed of an 8×8 Tx array arranged in a square shape and an 8+8 Rx array arranged in an L shape.The center-to-center distance between two adjacent elements is 0.54k0 for both the Tx and Rx arrays,where k0 is the free-space wavelength at 27 GHz.The proposed AFDBF array possesses a more compact structure and lower system hardware cost and power consumption compared with conventional brick-type full-digital arrays.In addition,the energy efficiency of the proposed AFDBF array outperforms that of a hybrid beamforming array.The measurement results indicate that the operating frequency band of the proposed array is 24.25–29.50 GHz.An eight-element linear array within the Tx array can achieve a scanning angle ranging from-47°to+47°in both the azimuth and the elevation planes,and the measured scanning range of each eight-element Rx array is–45°to+45°.The measured maximum effective isotropic radiated power(EIRP)of the eight-element Tx array is 43.2 dBm at 28.0 GHz(considering the saturation point).Furthermore,the measured error vector magnitude(EVM)is less than 3%when 64-quadrature amplitude modulation(QAM)waveforms are used. 展开更多
关键词 Full-digital beamforming array Asymmetric structure Single-board integrated Beyond fifth-generation and sixthgeneration Millimeter-wave communication Complex modulation Printed circuit board Vertical connection
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Strengthening effect of prefabrication(10-12)tensile twinning on AZ80+0.4%Ce magnesium alloy and inhibition mechanism of discontinuous precipitation
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作者 Zhen Wang Xi Zhao +5 位作者 Zhimin Zhang Yaojin Wu kai chen Xianwei Ren Dengkui Wang Wei Wang 《Journal of Magnesium and Alloys》 SCIE EI CAS CSCD 2024年第5期1918-1930,共13页
This paper provided an effective method to further improve the mechanical properties of the AZ80+0.4%Ce magnesium alloy wheel spoke.The effect of high strength and ductility was obtained with a yield strength of 295.3... This paper provided an effective method to further improve the mechanical properties of the AZ80+0.4%Ce magnesium alloy wheel spoke.The effect of high strength and ductility was obtained with a yield strength of 295.36 MPa,an elongation of 10%,by the combination of pre-deformation(7%deformation)and two-stage aging treatment(120℃/9 h+175℃/24 h).The evolution of the microstructure and properties of the alloy was explored under the coupling conditions of different pre-deformation degrees and multi-stage aging.The results show that,pre-deformation introduced a large number of(1012)tensile twinning and dislocations,which greatly promoted the probability of continuous precipitates(CPs)appearing.On the contrary,the discontinuous precipitates(DPs)were limited by the vertical and horizontal twin structure.As a result,the pre-nucleation method of two-stage aging increased the proportion of CPs by 34%-38%.Owing to the DPs was effectively suppressed,the alloy's yield strength has been greatly improved.Besides,under multi-stage aging,the twin boundaries induce protruding nucleation to form static recrystallization by hindering the migration of dislocations,and the matrix swallows the twins,then the texture gradually tilts from the two poles to the basal plane.As an important supplement,the grain refinement and oblique texture promoted the improvement of the yield strength of the component. 展开更多
关键词 Magnesium alloy Pre-deformed Two-stage aging Tensile twinning Continuous precipitates Texture
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A novel Effective Panicle Number per Plant 4 haplotype enhances grain yield by coordinating panicle number and grain number in rice
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作者 Yun Wang Xiaoqian Wang +6 位作者 Laiyuan Zhai Sundus Zafar Congcong Shen Shuangbing Zhu kai chen Yun Wang Jianlong Xu 《The Crop Journal》 SCIE CSCD 2024年第1期202-212,共11页
Increasing effective panicle number per plant(EPN)is one approach to increase yield potential in rice.However,molecular mechanisms underlying EPN remain unclear.In this study,we integrated mapbased cloning and genome-... Increasing effective panicle number per plant(EPN)is one approach to increase yield potential in rice.However,molecular mechanisms underlying EPN remain unclear.In this study,we integrated mapbased cloning and genome-wide association analysis to identify the EPN4 gene,which is allelic to NARROW LEAF1(NAL1).Overexpression lines containing the Teqing allele(TQ)of EPN4 had significantly increased EPN.NIL-EPN4^(TQ) in japonica(geng)cultivar Lemont(LT)exhibited significantly improved EPN but decreased grain number and flag leaf size relative to LT.Haplotype analysis indicated that accessions with EPN4-1 had medium EPN,medium grain number,and medium grain weight,but had the highest grain yield among seven haplotypes,indicating that EPN4-1 is an elite haplotype of EPN4 for positive coordination of the three components of grain yield.Furthermore,accessions carrying the combination of EPN4-1 and haplotype GNP1-6 of GNP1 for grain number per panicle showed higher grain yield than those with other allele combinations.Therefore,pyramiding of EPN4-1 and GNP1-6 could be a preferred approach to obtain high yield potential in breeding. 展开更多
关键词 RICE Effective panicle number per plant Grain number per panicle HAPLOTYPE Grain yield potential
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Genome-wide association study of seedling nitrogen-use efficiency-associated traits in common wheat(Triticum aestivum L.)
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作者 Huawei Shi Weichong Wang +14 位作者 Lifeng Gao Jirong Wu chengmei Hu Huishu Yan Yugang Shi Ning Li Youzhi Ma Yongbin Zhou Zhaoshi Xu Jun chen Wensi Tang kai chen Daizhen Sun Yuxiang Wu Ming chen 《The Crop Journal》 SCIE CSCD 2024年第1期222-231,共10页
Nitrogen(N)fertilizer application is essential for crop-plant growth and development.Identifying genetic loci associated with N-use efficiency(NUE)could increase wheat yields and reduce environmental pollution caused ... Nitrogen(N)fertilizer application is essential for crop-plant growth and development.Identifying genetic loci associated with N-use efficiency(NUE)could increase wheat yields and reduce environmental pollution caused by overfertilization.We subjected a panel of 389 wheat accessions to N and chlorate(a nitrate analog)treatments to identify quantitative trait loci(QTL)controlling NUE-associated traits at the wheat seedling stage.Genotyping the panel with a 660K single-nucleotide polymorphism(SNP)array,we identified 397 SNPs associated with N-sensitivity index and chlorate inhibition rate.These SNPs were merged into 49 QTL,of which eight were multi-environment stable QTL and 27 were located near previously reported QTL.A set of 135 candidate genes near the 49 QTL included TaBOX(F-box family protein)and TaERF(ethylene-responsive transcription factor).A Tabox mutant was more sensitive to low-N stress than the wild-type plant.We developed two functional markers for Hap 1,the favorable allele of TaBOX. 展开更多
关键词 WHEAT NUE Genome-wide association study Nitrogen sensitive index Chlorate inhibition rate
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Bearing Fault Diagnosis Based on Deep Discriminative Adversarial Domain Adaptation Neural Networks
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作者 Jinxi Guo kai chen +5 位作者 Jiehui Liu Yuhao Ma Jie Wu Yaochun Wu Xiaofeng Xue Jianshen Li 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第3期2619-2640,共22页
Intelligent diagnosis driven by big data for mechanical fault is an important means to ensure the safe operation ofequipment. In these methods, deep learning-based machinery fault diagnosis approaches have received in... Intelligent diagnosis driven by big data for mechanical fault is an important means to ensure the safe operation ofequipment. In these methods, deep learning-based machinery fault diagnosis approaches have received increasingattention and achieved some results. It might lead to insufficient performance for using transfer learning alone andcause misclassification of target samples for domain bias when building deep models to learn domain-invariantfeatures. To address the above problems, a deep discriminative adversarial domain adaptation neural networkfor the bearing fault diagnosis model is proposed (DDADAN). In this method, the raw vibration data are firstlyconverted into frequency domain data by Fast Fourier Transform, and an improved deep convolutional neuralnetwork with wide first-layer kernels is used as a feature extractor to extract deep fault features. Then, domaininvariant features are learned from the fault data with correlation alignment-based domain adversarial training.Furthermore, to enhance the discriminative property of features, discriminative feature learning is embeddedinto this network to make the features compact, as well as separable between classes within the class. Finally, theperformance and anti-noise capability of the proposedmethod are evaluated using two sets of bearing fault datasets.The results demonstrate that the proposed method is capable of handling domain offset caused by differentworkingconditions and maintaining more than 97.53% accuracy on various transfer tasks. Furthermore, the proposedmethod can achieve high diagnostic accuracy under varying noise levels. 展开更多
关键词 Fault diagnosis transfer learning domain adaptation discriminative feature learning correlation alignment
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A method for cleaning wind power anomaly data by combining image processing with community detection algorithms
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作者 Qiaoling Yang kai chen +2 位作者 Jianzhang Man Jiaheng Duan Zuoqi Jin 《Global Energy Interconnection》 EI CSCD 2024年第3期293-312,共20页
Current methodologies for cleaning wind power anomaly data exhibit limited capabilities in identifying abnormal data within extensive datasets and struggle to accommodate the considerable variability and intricacy of ... Current methodologies for cleaning wind power anomaly data exhibit limited capabilities in identifying abnormal data within extensive datasets and struggle to accommodate the considerable variability and intricacy of wind farm data.Consequently,a method for cleaning wind power anomaly data by combining image processing with community detection algorithms(CWPAD-IPCDA)is proposed.To precisely identify and initially clean anomalous data,wind power curve(WPC)images are converted into graph structures,which employ the Louvain community recognition algorithm and graph-theoretic methods for community detection and segmentation.Furthermore,the mathematical morphology operation(MMO)determines the main part of the initially cleaned wind power curve images and maps them back to the normal wind power points to complete the final cleaning.The CWPAD-IPCDA method was applied to clean datasets from 25 wind turbines(WTs)in two wind farms in northwest China to validate its feasibility.A comparison was conducted using density-based spatial clustering of applications with noise(DBSCAN)algorithm,an improved isolation forest algorithm,and an image-based(IB)algorithm.The experimental results demonstrate that the CWPAD-IPCDA method surpasses the other three algorithms,achieving an approximately 7.23%higher average data cleaning rate.The mean value of the sum of the squared errors(SSE)of the dataset after cleaning is approximately 6.887 lower than that of the other algorithms.Moreover,the mean of overall accuracy,as measured by the F1-score,exceeds that of the other methods by approximately 10.49%;this indicates that the CWPAD-IPCDA method is more conducive to improving the accuracy and reliability of wind power curve modeling and wind farm power forecasting. 展开更多
关键词 Wind turbine power curve Abnormal data cleaning Community detection Louvain algorithm Mathematical morphology operation
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Enhanced picosecond terahertz wave generation based on cascade effects in a terahertz parametric generator
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作者 张敬喜 王与烨 +5 位作者 徐炳烽 陈锴 刘紫鲲 马鸿儒 徐德刚 姚建铨 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第8期271-275,共5页
Enhanced terahertz wave generation via a Stokes cascade process has been demonstrated using picosecond pulse pumped terahertz parametric generation at 1 kHz repetition rate.Clear cascade saturation of terahertz output... Enhanced terahertz wave generation via a Stokes cascade process has been demonstrated using picosecond pulse pumped terahertz parametric generation at 1 kHz repetition rate.Clear cascade saturation of terahertz output was observed,and the corresponding cascade-Stokes spectra were analyzed.The maximum terahertz wave average power was 22μW under a pump power of 30 W,whereas the maximum power conversion efficiency was 8×10^(-7)under a pump power of 21 W.The THz power fluctuation was measured to be about 1%in 20 min.This THz parametric source with a relatively stable output is suitable for a variety of practical applications. 展开更多
关键词 terahertz parametric generation stimulated polariton cascade effect CLN crystal
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Effects of Mg-doping temperature on the structural and electrical properties of nonpolar a-plane p-type GaN films
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作者 陈凯 赵见国 +9 位作者 丁宇 胡文晓 刘斌 陶涛 庄喆 严羽 谢自力 常建华 张荣 郑有炓 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第1期631-636,共6页
Nonpolar(11–20) a-plane p-type GaN films were successfully grown on r-plane sapphire substrate with the metal–organic chemical vapor deposition(MOCVD) system. The effects of Mg-doping temperature on the structural a... Nonpolar(11–20) a-plane p-type GaN films were successfully grown on r-plane sapphire substrate with the metal–organic chemical vapor deposition(MOCVD) system. The effects of Mg-doping temperature on the structural and electrical properties of nonpolar p-type GaN films were investigated in detail. It is found that all the surface morphology, crystalline quality, strains, and electrical properties of nonpolar a-plane p-type GaN films are interconnected, and are closely related to the Mg-doping temperature. This means that a proper performance of nonpolar p-type GaN can be expected by optimizing the Mg-doping temperature. In fact, a hole concentration of 1.3×10^(18)cm^(-3), a high Mg activation efficiency of 6.5%,an activation energy of 114 me V for Mg acceptor, and a low anisotropy of 8.3% in crystalline quality were achieved with a growth temperature of 990℃. This approach to optimizing the Mg-doping temperature of the nonpolar a-plane p-type GaN film provides an effective way to fabricate high-efficiency optoelectronic devices in the future. 展开更多
关键词 nonpolar a-plane GaN film Mg-doping temperature strains activation efficiency
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NνDEx-100 conceptual design report
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作者 Xi-Guang Cao Yan-Long Chang +35 位作者 kai chen Emilio Ciuffoli Li-Min Duan Dong-Liang Fang Chao-Song Gao Surja K.Ghorui Peng-Chong Hu Qiang Hu Si-Yuan Huang Ze-Yu Huang Lei Lang Yu-Lan Li Zhi-Jie Li Tian-Yu Liang Jun Liu chen-Gui Lu Fa-Tai Mai Yuan Mei Hao Qiu Xiang-Ming Sun Xiao-Xing Tang Hu-Lin Wang Qian-Ming Wang Le Xiao Mu-Yun Xiao Jian-Yu Xin Nu Xu Peng Yang Yi-chen Yang Zhen Yang Zong-Yang Yu Dong-Liang Zhang Jun-Wei Zhang cheng-Xin Zhao Dou Zhu NνDEx-100 collaboration 《Nuclear Science and Techniques》 SCIE EI CAS CSCD 2024年第1期18-33,共16页
Observing nuclear neutrinoless double beta (0vββ) decay would be a revolutionary result in particle physics.Observing such a decay would prove that the neutrinos are their own antiparticles,help to study the absolut... Observing nuclear neutrinoless double beta (0vββ) decay would be a revolutionary result in particle physics.Observing such a decay would prove that the neutrinos are their own antiparticles,help to study the absolute mass of neutrinos,explore the origin of their mass,and may explain the matter-antimatter asymmetry in our universe by lepton number violation.We propose developing a time projection chamber (TPC) using high-pressure ^(82)SeF_(6) gas and Topmetal silicon sensors for readout in the China Jinping Underground Laboratory (CJPL) to search for neutrinoless double beta decay of82Se,called the NvDEx experiment.Besides being located at CJPL with the world’s thickest rock shielding,NvDEx combines the advantages of the high Qββ(2.996 MeV) of82Se and the TPC’s ability to distinguish signal and background events using their different topological characteristics.This makes NvDEx unique,with great potential for low-background and high-sensitivity 0 vββsearches.NvDEx-100,a NvDEx experiment phase with 100 kg of SeF_(6)gas,is being built,with plans to complete installation at CJPL by 2025.This report introduces 0 vββ physics,the NvDEx concept and its advantages,and the schematic design of NvDEx-100,its subsystems,and background and sensitivity estimation. 展开更多
关键词 Neutrinoless double beta decay Time projection chamber ^(82)SeF_(6) China Jinping Underground Laboratory
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Boosting Adversarial Training with Learnable Distribution
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作者 kai chen Jinwei Wang +2 位作者 James Msughter Adeke Guangjie Liu Yuewei Dai 《Computers, Materials & Continua》 SCIE EI 2024年第3期3247-3265,共19页
In recent years,various adversarial defense methods have been proposed to improve the robustness of deep neural networks.Adversarial training is one of the most potent methods to defend against adversarial attacks.How... In recent years,various adversarial defense methods have been proposed to improve the robustness of deep neural networks.Adversarial training is one of the most potent methods to defend against adversarial attacks.However,the difference in the feature space between natural and adversarial examples hinders the accuracy and robustness of the model in adversarial training.This paper proposes a learnable distribution adversarial training method,aiming to construct the same distribution for training data utilizing the Gaussian mixture model.The distribution centroid is built to classify samples and constrain the distribution of the sample features.The natural and adversarial examples are pushed to the same distribution centroid to improve the accuracy and robustness of the model.The proposed method generates adversarial examples to close the distribution gap between the natural and adversarial examples through an attack algorithm explicitly designed for adversarial training.This algorithm gradually increases the accuracy and robustness of the model by scaling perturbation.Finally,the proposed method outputs the predicted labels and the distance between the sample and the distribution centroid.The distribution characteristics of the samples can be utilized to detect adversarial cases that can potentially evade the model defense.The effectiveness of the proposed method is demonstrated through comprehensive experiments. 展开更多
关键词 Adversarial training feature space learnable distribution distribution centroid
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Pan-cancer analysis of RNA 5-methylcytosine reader (ALYREF)
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作者 XING YE ZHOUTING TUO +10 位作者 kai chen RUIchenG WU JIE WANG QINGXIN YU LUXIA YE AKIRA MIYAMOTO KOO HAN YOO CHI ZHANG WURAN WEI DENGXIONG LI DECHAO FENG 《Oncology Research》 SCIE 2024年第3期503-515,共13页
The incre asing interest in RNA modifications has signifcantly advanced epigenomic and epitranscriptomic technologies.This study focuses on the immuno oncological impact of ALYREF in human cancer through a pan-cancer ... The incre asing interest in RNA modifications has signifcantly advanced epigenomic and epitranscriptomic technologies.This study focuses on the immuno oncological impact of ALYREF in human cancer through a pan-cancer analysis,enhancing understanding of this gene's role in cancer.We observed differential ALYREF expression between tumor and normal samples,correl ating strongly with prognosis in various cancers,particularly kidney renal papillary cell carcinoma(KIRP)and liver hepatocellular carcinoma(LIHC).ALYREF showed a negative correlation with most tumor-infitrating cells in lung squamous cell carcinoma(LUSC)and lymphoid neoplasm difuse large B-cell lymphoma(DLBC),while positive correlations were noted in IIHC,kidney chromophobe(KICH),mesothelioma(MESO),KIRP,pheochromocytoma and paraganglioma(PARD),and glioma(GBMLGG).Aditionally,ALYREF expression was closely associated with tumor heterogeneity,stemness indices,and a high mutation rate in TP53 across these cancers.In conclusion,ALYREF may serve as an oncogenic biomarker in numerous cancers,meriting further research attention. 展开更多
关键词 Pan-cancer RNA 5-methylcytosine ALYREF Immwno-oncological efects
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Sinomenine increases osteogenesis in mice with ovariectomyinduced bone loss by modulating autophagy
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作者 Hai-Xiang Xiao Lei Yu +7 位作者 Yu Xia kai chen Wen-Ming Li Gao-Ran Ge Wei Zhang Qing Zhang Hong-Tao Zhang De-Chun Geng 《World Journal of Stem Cells》 SCIE 2024年第5期486-498,共13页
BACKGROUND A decreased autophagic capacity of bone marrow mesenchymal stromal cells(BMSCs)has been suggested to be an important cause of decreased osteogenic differentiation.A pharmacological increase in autophagy of ... BACKGROUND A decreased autophagic capacity of bone marrow mesenchymal stromal cells(BMSCs)has been suggested to be an important cause of decreased osteogenic differentiation.A pharmacological increase in autophagy of BMSCs is a potential therapeutic option to increase osteoblast viability and ameliorate osteoporosis.AIM To explore the effects of sinomenine(SIN)on the osteogenic differentiation of BMSCs and the underlying mechanisms.METHODS For in vitro experiments,BMSCs were extracted from sham-treated mice and ovariectomized mice,and the levels of autophagy markers and osteogenic differentiation were examined after treatment with the appropriate concen-trations of SIN and the autophagy inhibitor 3-methyladenine.In vivo,the therapeutic effect of SIN was verified by establishing an ovariectomy-induced mouse model and by morphological and histological assays of the mouse femur.RESULTS SIN reduced the levels of AKT and mammalian target of the rapamycin(mTOR)phosphorylation in the phosphatidylinositol 3-kinase(PI3K)/AKT/mTOR signaling pathway,inhibited mTOR activity,and increased autophagy ability of BMSCs,thereby promoting the osteogenic differentiation of BMSCs and effectively alleviating bone loss in ovariectomized mice in vivo.CONCLUSION The Chinese medicine SIN has potential for the treatment of various types of osteoporosis,bone homeostasis disorders,and autophagy-related diseases. 展开更多
关键词 SINOMENINE OSTEOGENESIS AUTOPHAGY OVARIECTOMY OSTEOPOROSIS
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Transglutaminase 2 serves as a pathogenic hub gene of KRAS mutant colon cancer based on integrated analysis
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作者 Wei-Bin Peng Yu-Ping Li +1 位作者 Yong Zeng kai chen 《World Journal of Gastrointestinal Oncology》 SCIE 2024年第5期2074-2090,共17页
BACKGROUND Colon cancer is acknowledged as one of the most common malignancies worldwide,ranking third in United States regarding incidence and mortality.Notably,approximately 40%of colon cancer cases harbor oncogenic... BACKGROUND Colon cancer is acknowledged as one of the most common malignancies worldwide,ranking third in United States regarding incidence and mortality.Notably,approximately 40%of colon cancer cases harbor oncogenic KRAS mutations,resulting in the continuous activation of epidermal growth factor receptor signaling.AIM To investigate the key pathogenic genes in KRAS mutant colon cancer holds considerable importance.METHODS Weighted gene co-expression network analysis,in combination with additional bioinformatics analysis,were conducted to screen the key factors driving the progression of KRAS mutant colon cancer.Meanwhile,various in vitro experiments were also conducted to explore the biological function of transglutaminase 2(TGM2).RESULTS Integrated analysis demonstrated that TGM2 acted as an independent prognostic factor for progression-free survival.Immunohistochemical analysis on tissue microarrays revealed that TGM2 was associated with an elevated probability of perineural invasion in patients with KRAS mutant colon cancer.Additionally,biological roles of the key gene TGM2 was also assessed,suggesting that the downregulation of TGM2 attenuated the proliferation,invasion,and migration of the KRAS mutant colon cancer cell line.CONCLUSION This study underscores the potential significance of TGM2 in the progression of KRAS mutant colon cancer.This insight not only offers a theoretical foundation for therapeutic approaches but also highlights the need for additional clinical trials and fundamental research to support our preliminary findings. 展开更多
关键词 Colon cancer KRAS mutation Transglutaminase 2 Weighted gene co-expression network analysis
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An organic visible-photocatalytic-adsorbence mechanism to high-efficient removal of heavy metal antimony ions
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作者 Linji Yang Ke Sun +11 位作者 Tao Liu Ciyuan Huang Libin Zhang Yang Zhou kai chen Shangfei Yao Ziyang Zhang chenfu Zhao Hongxiang Zhu Bingsuo Zou Shuangfei Wang Dongfeng Xue 《Materials Reports(Energy)》 EI 2024年第3期49-59,共11页
Purification of emerging heavy metal antimony contaminated water based on advanced ingenious strategies.An activated modified coconut shell charcoal(CSC)was synthesized and evaluated as a substrate-supported loaded or... Purification of emerging heavy metal antimony contaminated water based on advanced ingenious strategies.An activated modified coconut shell charcoal(CSC)was synthesized and evaluated as a substrate-supported loaded organic photovoltaic material,PM6:PYIT:PM6-b-PYIT,to prepare a surprisingly highly efficient,stable,environmentally friendly,and recyclable organic photocatalyst(CSC–N–P.P.P),which showed excellent effects on the simultaneous removal of Sb(Ⅲ)and Sb(Ⅴ).The removal efficiency of CSC-N-P.P.P on Sb(Ⅲ)and Sb(Ⅴ)reached an amazing 99.9%in quite a short duration of 15 min.At the same time,under ppb level and indoor visible light(~1 W m^(2)),it can be treated to meet the drinking water standards set by the European Union and the U.S.National Environmental Protection Agency in 5 min,and even after 25 cycles of recycling,the efficiency is still maintained at about 80%,in addition to the removal of As(Ⅲ),Cd(Ⅱ),Cr(Ⅵ),and Pb(Ⅱ)can also be realized.The catalyst not only solves the problems of low reuse rate,difficult structure adjustment and high energy consumption of traditional photocatalysts but also has strong applicability and practical significance.The pioneering approach provides a much-needed solution strategy for removing highly toxic heavy metal antimony pollution from the environment. 展开更多
关键词 Organic photocatalyst PHOTOCATALYSIS Purification Indoor visible light
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Sorafenib plus transarterial chemoembolization vs sorafenib alone for patients with advanced hepatocellular carcinoma: A systematic review and meta-analysis
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作者 Hong-Jie Yang Bin Ye +2 位作者 Jia-Xu Liao Lei Lei kai chen 《World Journal of Hepatology》 2024年第1期91-102,共12页
BACKGROUND Although the past decade has seen remarkable advances in treatment options for hepatocellular carcinoma(HCC),the dismal overall prognosis still envelops HCC patients.Several comparative trials have been con... BACKGROUND Although the past decade has seen remarkable advances in treatment options for hepatocellular carcinoma(HCC),the dismal overall prognosis still envelops HCC patients.Several comparative trials have been conducted to study whether transarterial chemoembolization(TACE)could improve clinical outcomes in patients receiving sorafenib for advanced HCC;however,the findings have been inconsistent.AIM To study the potential synergies and safety of sorafenib plus TACE vs sorafenib alone for treating advanced HCC,by performing a systematic review and metaanalysis.METHODS This study was conducted following the PRISMA statement.A systematic literature search was conducted using the Cochrane Library,Embase,PubMed,and Web of Science databases.Data included in the present work were collected from patients diagnosed with advanced HCC receiving sorafenib plus TACE or sorafenib alone.Data synthesis and meta-analysis were conducted using Review Manager software.RESULTS The present study included 2780 patients from five comparative clinical trials(1 was randomized control trial and 4 were retrospective studies).It was found that patients receiving sorafenib plus TACE had better prognoses in terms of overall survival(OS),with a combined hazard ratio(HR)of 0.65[95%confidence interval(95%CI):0.46–0.93,P=0.02,n=2780].Consistently,progression free survival(PFS)and time to progression(TTP)differed significantly between the sorafenib plus TACE arm and sorafenib arm(PFS:HR=0.62,95%CI:0.40–0.96,P=0.03,n=443;TTP:HR=0.73,95%CI:0.64-0.83,P<0.00001,n=2451).Disease control rate(DCR)was also significantly increased by combination therapy(risk ratio=1.36,95%CI:1.02-1.81,P=0.04,n=641).Regarding safety,the incidence of any adverse event(AE)was increased due to the addition of TACE;however,no significant difference was found in grade≥3 AEs.CONCLUSION The combination of sorafenib with TACE has superior efficacy to sorafenib monotherapy,as evidenced by prolonged OS,PFS,and TTP,as well as increased DCR.Additional high-quality trials are essential to further validate the clinical benefit of this combination in the treatment of advanced HCC. 展开更多
关键词 Hepatocellular carcinoma SORAFENIB Transarterial chemoembolization Systematic review META-ANALYSIS
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基于无人机携带自主避障功能研究
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作者 陈凯 朱建军 +3 位作者 李汶翰 王远新 竺子淞 付坤 《现代工业经济和信息化》 2024年第5期79-81,共3页
针对解决心脏病患者和突发事故导致需要做心肺复苏的人的需求,提出了一种无人机携带自主避障功能研究的方法。通过双目摄像头、毫米波雷达、红外测距传感器三者完成无人机的避障功能,通过所设计的一款磁吸装置以及配套的收纳盒装置以完... 针对解决心脏病患者和突发事故导致需要做心肺复苏的人的需求,提出了一种无人机携带自主避障功能研究的方法。通过双目摄像头、毫米波雷达、红外测距传感器三者完成无人机的避障功能,通过所设计的一款磁吸装置以及配套的收纳盒装置以完成无人机的携带功能。 展开更多
关键词 自主避障 红外测距 无人机 抗干扰 AED
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