The flotation of hemimorphite using the S(Ⅱ)–Pb(Ⅱ)–xanthate process,which includes sulfidization with sodium sulfide,activation by lead cations,and subsequent flotation with xanthate,was investigated.The flotation...The flotation of hemimorphite using the S(Ⅱ)–Pb(Ⅱ)–xanthate process,which includes sulfidization with sodium sulfide,activation by lead cations,and subsequent flotation with xanthate,was investigated.The flotation results indicated that hemimorphite floats when the S(Ⅱ)–Pb(Ⅱ)–xanthate process is used; a maximum recovery of approximately 90% was obtained.Zeta-potential,contact-angle,scanning electron microscopy–energy-dispersive spectrometry(SEM–EDS),and diffuse-reflectance infrared Fourier transform spectroscopy(DRIFTS) measurements were used to characterize the activation products on the hemimorphite surface and their subsequent interaction with sodium butyl xanthate(SBX).The results showed that a Zn S coating formed on the hemimorphite surface after the sample was conditioned in an Na2 S solution.However,the formation of a Zn S coating on the hemimorphite surface did not improve hemimorphite flotation.With the subsequent addition of lead cations,Pb S species formed on the mineral surface.The formation of the Pb S species on the surface of hemimorphite significantly increased the adsorption capacity of SBX,forming lead xanthate(referred to as chemical adsorption) and leading to a substantial improvement in hemimorphite flotation.Our results indicate that the addition of lead cations is a critical step in the successful flotation of hemimorphite using the sulfidization–lead ion activation–xanthate process.展开更多
A simple and rapid UPLC–MS/MS method to simultaneously determine gemcitabine and its L-carnitine ester derivative(2’-deoxy-2’, 2’-difluoro-N-((4-amino-4-oxobutanoyl) oxy)-4-(trimethyl amm-onio) butanoate-cytidine,...A simple and rapid UPLC–MS/MS method to simultaneously determine gemcitabine and its L-carnitine ester derivative(2’-deoxy-2’, 2’-difluoro-N-((4-amino-4-oxobutanoyl) oxy)-4-(trimethyl amm-onio) butanoate-cytidine, JDR) in rat plasma was developed and validated.The conventional plasma sample preparation method of nucleoside analogues is solidphase extraction(SPE) which is time-consuming and cost-expensive. In this study, gradient elution with small particles size solid phase was applied to effectively separate gemcitabine and JDR, and protein precipitation pretreatment was adopted to remove plasma protein and extract the analytes with high recovery(>81%). Method validation was performed as per the FDA guidelines, and the standard curves were found to be linear in the range of 5–4000 ng/ml for JDR and 4–4000 ng/ml for gemcitabine, respectively. The lower limit of quantitation(LLOQ)of gemcitabine and JDR was 4 and 5 ng/ml, respectively. The intra-day and inter-day precision and accuracy results were within the acceptable limits. Finally, the developed method was successfully applied to investigate the pharmacokinetic studies of JDR and gemcitabine after oral administration to rats.展开更多
Lithium-rich layered oxides(LrLOs) deliver extremely high specific capacities and are considered to be promising candidates for electric vehicle and smart grid applications. However, the application of LrLOs needs fur...Lithium-rich layered oxides(LrLOs) deliver extremely high specific capacities and are considered to be promising candidates for electric vehicle and smart grid applications. However, the application of LrLOs needs further understanding of the structural complexity and dynamic evolution of monoclinic and rhombohedral phases, in order to overcome the issues including voltage decay, poor rate capability, initial irreversible capacity loss and etc. The development of aberration correction for the transmission electron microscope and concurrent progress in electron spectroscopy, have fueled rapid progress in the understanding of the mechanism of such issues. New techniques based on the transmission electron microscope are first surveyed, and the applications of these techniques for the study of the structure, migration of transition metal, and the activation of oxygen of LrLOs are then explored in detail, with a particular focus on the mechanism of voltage decay.展开更多
Water conveyance tunnels usually experience high internal water pressures and complex soil conditions.Therefore,shield tunnels with double-lining structure have been adopted because of their high bearing capacity.The ...Water conveyance tunnels usually experience high internal water pressures and complex soil conditions.Therefore,shield tunnels with double-lining structure have been adopted because of their high bearing capacity.The effect of the interface between the segmental and inner linings on the bearing capacity has been widely investigated;however,the effect of soil on the internal water pressure bearing capacity has not been emphasized enough.Therefore,in this study,model tests and an analytical solution are presented to elucidate the effect of soil on the internal water pressure bearing capacity.First,model tests are conducted on double-lining models under sandy soil and highly weathered argillaceous siltstone conditions.The internal force and earth pressure under these different soil conditions are then compared to reveal the contribution of soil to the internal water pressure bearing capacity.Following this,an analytical solution,considering the soil–double-lining interaction,is proposed to further investigate the contribution of the soil.The analytical solution is verified with model tests.The analytical solution is in good agreement with the model test results and can be used to evaluate the mechanical behavior of the double-lining and soil contribution.The effect of soil on the bearing capacity is found to be related with the elastic modulus of the soil and the deformation state of the double-lining.Before the double-lining cracks,the sandy soil contributes 3.7%of the internal water pressure but the contribution of the soil rises to 10.4%when it is the highly weathered argillaceous siltstone.After the double-lining cracks,the soil plays an important role in bearing internal water pressure.The soil contributions of sandy soil and highly weathered argillaceous siltstones are 10.5%and 27.8%,respectively.The effect of soil should be considered in tunnel design with the internal water pressure.展开更多
In order to study the Yamabe changing-sign problem,Bahri and Xu proposed a conjecture which is a universal inequality for p points in R^(m).They have verified the conjecture for p≤3.In this paper,we first simplify th...In order to study the Yamabe changing-sign problem,Bahri and Xu proposed a conjecture which is a universal inequality for p points in R^(m).They have verified the conjecture for p≤3.In this paper,we first simplify this conjecture by giving two sufficient and necessary conditions inductively.Then we prove the conjecture for the basic case m=1 with arbitrary p.In addition,for the cases when p=4,5 and m≥2,we manage to reduce them to the basic case m=1 and thus prove them as well.展开更多
基金financially supported by the State Key Development Program for Basic Research of China (No.2014CB643402)the Collaborative Innovation Center for Clean and Efficient Utilization of Strategic Metal Mineral Resources of Central South University
文摘The flotation of hemimorphite using the S(Ⅱ)–Pb(Ⅱ)–xanthate process,which includes sulfidization with sodium sulfide,activation by lead cations,and subsequent flotation with xanthate,was investigated.The flotation results indicated that hemimorphite floats when the S(Ⅱ)–Pb(Ⅱ)–xanthate process is used; a maximum recovery of approximately 90% was obtained.Zeta-potential,contact-angle,scanning electron microscopy–energy-dispersive spectrometry(SEM–EDS),and diffuse-reflectance infrared Fourier transform spectroscopy(DRIFTS) measurements were used to characterize the activation products on the hemimorphite surface and their subsequent interaction with sodium butyl xanthate(SBX).The results showed that a Zn S coating formed on the hemimorphite surface after the sample was conditioned in an Na2 S solution.However,the formation of a Zn S coating on the hemimorphite surface did not improve hemimorphite flotation.With the subsequent addition of lead cations,Pb S species formed on the mineral surface.The formation of the Pb S species on the surface of hemimorphite significantly increased the adsorption capacity of SBX,forming lead xanthate(referred to as chemical adsorption) and leading to a substantial improvement in hemimorphite flotation.Our results indicate that the addition of lead cations is a critical step in the successful flotation of hemimorphite using the sulfidization–lead ion activation–xanthate process.
基金the financial support from the National Natural Science Foundation of China (No. 81173009)Technology Bureau in Shenyang (No. ZCJJ2013402)+2 种基金the financial support from Project for New Century Excellent Talents of Ministry of Education (No.NCET-12-1015)Specific Science Foundation of Shenyang Pharmaceutical University (No. ZCJJ2014409)National Undergraduate Training Program for Innovation and Entrepreneurship (2016)
文摘A simple and rapid UPLC–MS/MS method to simultaneously determine gemcitabine and its L-carnitine ester derivative(2’-deoxy-2’, 2’-difluoro-N-((4-amino-4-oxobutanoyl) oxy)-4-(trimethyl amm-onio) butanoate-cytidine, JDR) in rat plasma was developed and validated.The conventional plasma sample preparation method of nucleoside analogues is solidphase extraction(SPE) which is time-consuming and cost-expensive. In this study, gradient elution with small particles size solid phase was applied to effectively separate gemcitabine and JDR, and protein precipitation pretreatment was adopted to remove plasma protein and extract the analytes with high recovery(>81%). Method validation was performed as per the FDA guidelines, and the standard curves were found to be linear in the range of 5–4000 ng/ml for JDR and 4–4000 ng/ml for gemcitabine, respectively. The lower limit of quantitation(LLOQ)of gemcitabine and JDR was 4 and 5 ng/ml, respectively. The intra-day and inter-day precision and accuracy results were within the acceptable limits. Finally, the developed method was successfully applied to investigate the pharmacokinetic studies of JDR and gemcitabine after oral administration to rats.
基金finically supported by the National Key Research and Development Program of China (Grant No. 2016YFB0100100)Strategic Priority Research Program of Chinese Academy of Sciences (CAS, Grant No. XDA09010101)Ningbo Key Science and Technology Projects "Industrial Application Development of Graphene" (Grant No. 2014S10008)
文摘Lithium-rich layered oxides(LrLOs) deliver extremely high specific capacities and are considered to be promising candidates for electric vehicle and smart grid applications. However, the application of LrLOs needs further understanding of the structural complexity and dynamic evolution of monoclinic and rhombohedral phases, in order to overcome the issues including voltage decay, poor rate capability, initial irreversible capacity loss and etc. The development of aberration correction for the transmission electron microscope and concurrent progress in electron spectroscopy, have fueled rapid progress in the understanding of the mechanism of such issues. New techniques based on the transmission electron microscope are first surveyed, and the applications of these techniques for the study of the structure, migration of transition metal, and the activation of oxygen of LrLOs are then explored in detail, with a particular focus on the mechanism of voltage decay.
基金the Innovation Program of Shanghai Municipal Education Commission(No.2019-01-0700-07-456 E00051)the National Natural Science Foundation of China(Nos.51978517,52090082,and 52108381)the Shanghai Science and Technology Committee Program(Nos.21DZ1200601 and 20DZ1201404)。
文摘Water conveyance tunnels usually experience high internal water pressures and complex soil conditions.Therefore,shield tunnels with double-lining structure have been adopted because of their high bearing capacity.The effect of the interface between the segmental and inner linings on the bearing capacity has been widely investigated;however,the effect of soil on the internal water pressure bearing capacity has not been emphasized enough.Therefore,in this study,model tests and an analytical solution are presented to elucidate the effect of soil on the internal water pressure bearing capacity.First,model tests are conducted on double-lining models under sandy soil and highly weathered argillaceous siltstone conditions.The internal force and earth pressure under these different soil conditions are then compared to reveal the contribution of soil to the internal water pressure bearing capacity.Following this,an analytical solution,considering the soil–double-lining interaction,is proposed to further investigate the contribution of the soil.The analytical solution is verified with model tests.The analytical solution is in good agreement with the model test results and can be used to evaluate the mechanical behavior of the double-lining and soil contribution.The effect of soil on the bearing capacity is found to be related with the elastic modulus of the soil and the deformation state of the double-lining.Before the double-lining cracks,the sandy soil contributes 3.7%of the internal water pressure but the contribution of the soil rises to 10.4%when it is the highly weathered argillaceous siltstone.After the double-lining cracks,the soil plays an important role in bearing internal water pressure.The soil contributions of sandy soil and highly weathered argillaceous siltstones are 10.5%and 27.8%,respectively.The effect of soil should be considered in tunnel design with the internal water pressure.
基金partially supported by Beijing Natural Science Foundation(Grant No.Z190003)partially supported by National Sciences Foundation of USA(Grant No.DMS-19-08513)。
文摘In order to study the Yamabe changing-sign problem,Bahri and Xu proposed a conjecture which is a universal inequality for p points in R^(m).They have verified the conjecture for p≤3.In this paper,we first simplify this conjecture by giving two sufficient and necessary conditions inductively.Then we prove the conjecture for the basic case m=1 with arbitrary p.In addition,for the cases when p=4,5 and m≥2,we manage to reduce them to the basic case m=1 and thus prove them as well.