利用ToF-SIMS和Rf-GDOES深度剖析技术研究柔性衬底上的隔热多层膜

目的:探究隔热多层膜VG1的层结构和光学性能。方法:利用飞行时间二次离子质谱(Time of Flight Secondary Ion Mass Spectroscopy, ToF-SIMS)和射频辉光放电发射光谱(Radio-Frequency Glow Dis-charge Optical Emission Spectroscopy, Rf-GDOES)深度剖析技术,对PET柔性衬底上的隔热多层膜进行了成分分布和层结构的对比研究。利用Mixing-Roughness-Information (MRI)模型对测量的深度剖析谱进行了定量分析,并利用分光光度计对多层膜的光学性能进行表征。结果:通过深度剖析的定量分析,确定了所研究隔热多层膜主要组成元素的成分随深度变化的分布为:Nb2O5 (~25 nm)/AZO (Ag) (~10 nm)/Nb2O5 (~50 nm)/AZO (Ag) (~10 nm)/Nb2O5 (~25 nm),整个薄膜厚度约为120 nm。利用深度剖析数据拟合获得的粗糙度参数随深度变化的关系,估算出ToF-SIMS和Rf-GDOES深度剖析溅射到第二个Ag峰前界面处的粗糙度分别为1.2 nm和4.6 nm。对透过率的表征发现,该多层膜样品较PET衬底可见光的透过率增加了11%,而红外光的透过率降低了66%。结论:利用Rf-GDOES和ToF-SIMS溅射深度剖析定量分析技术,确定了柔性衬底上隔热功能薄膜的元素成分分布、膜厚及膜层间界面粗糙度,并利用分光光度计定量确定了该隔热功能多层膜的透过率。

200-nm long TiO_2 nanorod arrays for efficient solid-state Pb S quantum dot-sensitized solar cellsR

To ensure the infiltration of spiro-OMeTAD into the quantum dot-sensitized photoanode and to consider the limit of the hole diffusion length in the spiro-OMeTAD layer, a rutile TiO2 nanorod array with a length of 200 nm, a diameter of 20 nm and an areal density of 720 ram 2 was successfully prepared using a hydrothermal method with an aqueous-grown solution of 38 mM titanium isopropoxide and 6 M hydrochloric acid at 170 ℃ for 75 min. PbS quantum dots were deposited by a spin coating-assisted successive ionic layer adsorption and reaction （spin-SILAR）, and all solid-state PbS quantum dot-sensitized TiO2 nanorod array solar cells were fabricated using spiro-OMeTAD as electrolytes. The results revealed that the average crystal size of PbS quantum dots was -78 nm using Pb（NO3）2 as the lead source and remain unchanged with the increase of the number of spin-SILAR cycles. The all solid-state PbS quantum dot-sensitized TiO2 nanorod array solar cells with spin-SILAR cycle numbers of 20, 30 and 40 achieved the photoelectric conversion efficiencies of 3.74%, 4.12% and 3.11%, respectively, under AM 1.5 G illumination （100 mW/cm2）.

Repurposing of berbamine hydrochloride to inhibit Ebola virus by targeting viral glycoprotein

Ebola virus(EBOV)infection leads to staggeringly high mortality rate.Effective and low-cost treatments are urgently needed to control frequent EBOV outbreaks in Africa.In this study,we report that a natural compound called berbamine hydrochloride strongly inhibits EBOV replication in vitro and in vivo.Our work further showed that berbamine hydrochloride acts by directly binding to the cleaved EBOV glycoprotein(GPcl),disrupting GPcl interaction with viral receptor Niemann-Pick C1,thus blocking the fusion of viral and cellular membranes.Our data support the probability of developing anti-EBOV small molecule drugs by targeting viral GPcl.More importantly,since berbamine hydrochloride has been used in clinic to treat leukopenia,it holds great promise of being quickly repurposed as an anti-EBOV drug.

The pyrolysis preparation of the compact and full-coverage AgSbS_(2) thin films and the photovoltaic performance of the corresponding solar cells

The preparation of the compact and full-coverage AgSbS;thin films is firstly reported using the pyrolysis of the Ag-butyldithiocarbamate and Sb-butyldithiocarbamate complex solution in DMF.The influence of the preparation temperature on the crystal phase,optical absorption,morphology of the AgSbS;thin films is systematically investigated.The AgSbS;thin films at 150°C for 30 min are composed of the individual nanoparticles with the particle sizes of 30–60 nm.When the AgSbS_(2)thin films are further heated at 350℃for 2 min,the individual AgSbS_(2)nanoparticles are melted together and the grain boundary between the AgSbS_(2)nanoparticles disappear.The solar cells with the architecture of FTO/compact TiO_(2)/AgSbS_(2)/spiro-OMe TAD/Au achieve the photoelectric conversion efficiency(PCE)of 2.09%,along with the open-circuit voltage of 0.44 V,the short-circuit photocurrent density of 10.49 m A cm^(-2),the fill factor of 0.45.The PCE of 2.09%is the highest value for the AgSbS_(2)solar cells.

Observation of oxygen evolution over a {Ni12}-cluster-based metal-organic framework

The development of efficient electrocatalysts based on non-noble metals for oxygen evolution reaction(OER) remains an important and challenging task. Multinuclear transition-metal clusters with high structural stability are promising OER catalysts but their catalytic role is poorly understood. Here we report the crystallographic observation of OER activity over robust {Ni12}-clusters immobilised in a porous metal-organic framework, NKU-100, by single-crystal X-ray diffraction as a function of external applied potential. We observed the aggregation of confined oxygen species around the {Ni12}-cluster as a function of applied potential during the electrocatalytic process. The refined occupancy of these oxygen species shows a strong correlation with the variation of current density. This study demonstrates that the enrichment of oxygen species in the secondary coordination sphere of multinuclear transition-metal clusters can promote the OER activity.

N-(2-Phenoxy)ethyl imidazo[1,2-a]pyridine-3-carboxamides containing various amine moieties:Design,synthesis and antitubercular activity

Seven 2,6-disubstituted N-(2-phenoxy)ethyl imidazo[1,2-a]pyridine-3-carboxamide series containing various amine moieties were designed and synthesized as new anti-TB agents.Many of them show excellent in vitro activity against both drug-sensitive MTB strain H37Rv and two MDR-MTB clinical isolates(MIC:<0.002-0.030 μg/mL).Compounds 2f,5e and 5g display acceptable safety and pharmacokinetic profiles,opening a new direction for further development.

Design,synthesis and antimycobacterial activity of novel nitrobenzamide derivatives

We report herein the design and synthesis of a series of novel nitrobenzamide derivatives. Results reveal that many of them display considerable in vitro antitubercular activity. Four N-benzyl or N- (pyridine-2-yl)methyl 3,5-dinitrobenzamides A6, All, Cl and C4 have not only the same excellent MIC values of<0.016 μg/mL against both drug-sensitive MTB strain H37 Rv and two drug-resistant clinical isolates as PBTZ169 and the lead 1, but also acceptable safety indices (SI > 1500), opening a new direction for further development.