Over the past two decades,superhydrophobic surfaces that are easily created have aroused considerable attention for their superior performances in various applications at room temperature.Nowadays,there is a growing d...Over the past two decades,superhydrophobic surfaces that are easily created have aroused considerable attention for their superior performances in various applications at room temperature.Nowadays,there is a growing demand in special fields for the development of surfaces that can resist wetting by high-temperature molten droplets(>1200°C)using facile design and fabrication strategies.Herein,bioinspired directional structures(BDSs)were prepared on Y2O3-stabilized ZrO2(YSZ)surfaces using femtosecond laser ablation.Benefiting from the anisotropic energy barriers,the BDSs featured with no additional modifiers showed a remarkable increase from 9.2°to 60°in the contact angle of CaO–MgO–Al2O3–SiO2(CMAS)melt and a 70.1%reduction in the spreading area of CMAS at 1250°C,compared with polished super-CMAS-melt-philic YSZ surfaces.Moreover,the BDSs demonstrated exceptional wetting inhibition even at 1400°C,with an increase from 3.3°to 31.3°in contact angle and a 67.9%decrease in spreading area.This work provides valuable insight and a facile preparation strategy for effectively inhibiting the wetting of molten droplets on super-melt-philic surfaces at extremely high temperatures.展开更多
OBJECTIVE: To evaluate the predictive value of magnetic resonance cholangiography (MRC) in selected patients before laparoscopic cholecystectomy (LC). METHODS: Patients with risk factors for common bile duct (CBD) sto...OBJECTIVE: To evaluate the predictive value of magnetic resonance cholangiography (MRC) in selected patients before laparoscopic cholecystectomy (LC). METHODS: Patients with risk factors for common bile duct (CBD) stones scheduled for elective LC from March 1999 to May 2001, underwent MRC followed by endoscopic retrograde cholangiography (ERC) to detect the stones and the accuracy of MRC. Selection of suspected patients was based on clinical, ultrasonographic, and laboratory criteria. RESULTS: During a 26-month period, a total of 267 patients were studied. Seventy-eight MRC identified patients were found to have CBD stones by ERC or laparoscopic cholangiography in the study. Seven of 78 patients were misdiagnosed as having CBD stones by MRC. In this study, MRC had a sensitivity of 100%, a specificity of 96.3%, a positive predictive value of 91.8%, and a negative predictive value of 100% for the detection of common bile duct stones. CONCLUSIONS: With the use of LC, ERC is frequently performed before LC to detect CBD stones; but it is invasive with a well-documented complication rate. MRC is a simple non-invasive method for preoperative screening for CBD stones in at-risk patients. In this study if ERC had been limited to patients with a positive MRC, it would have reduced the need for ERC by 68.2%, and the complications of preoperative examination would be minimized significantly.展开更多
Versatile liquid manipulating surfaces combining patternable and controllable wettability have recently motivated considerable attention owing to their significant advantages in droplet-solid impacting behaviors,micro...Versatile liquid manipulating surfaces combining patternable and controllable wettability have recently motivated considerable attention owing to their significant advantages in droplet-solid impacting behaviors,microdroplet self-removal,and liquid–liquid interface reaction applications.However,developing a facile and efficient method to fabricate these versatile surfaces remains an enormous challenge.In this paper,a strategy for the fabrication of liquid manipulating surfaces with patternable and controllable wettability on Polyimide(PI)film based on femtosecond laser thermal accumulation engineering is proposed.Because of its controllable micro-/nanostructures and chemical composition through adjusting the local thermal accumulation,the wettability of PI film can be tuned from superhydrophilicity(~3.6°)to superhydrophobicity(~151.6°).Furthermore,three diverse surfaces with patternable and heterogeneous wettability were constructed and various applications were successfully realized,including water transport,droplet arrays,and liquid wells.This work may provide a facile strategy for achieving patternable and controllable wettability efficiently and developing multifunctional liquid steering surfaces.展开更多
At present,the domestic agriculture is facing challenges.Farmers' income is relatively low,and more and more rural young workers are divorced from the countryside to work in the relatively developed areas,which ma...At present,the domestic agriculture is facing challenges.Farmers' income is relatively low,and more and more rural young workers are divorced from the countryside to work in the relatively developed areas,which makes agricultural development caught in a vicious circle,so it is difficult to rationally allocate resources and increase industrial vitality.However,the new agricultural system of " Chongzhou Mode" has emerged to indicate a macro direction of agricultural development.In this paper,with " Chongzhou Mode" as the object of study,from the perspective of modern enterprise management,we elaborate some features of this mode such as corporate governance,land transfer cost internalization and human-based management,and explore the role of this mode in promoting employment,Internet +,and reducing market information asymmetry.Finally,we set forth the corresponding展开更多
To improve the nitriding resistance of Zr_(2)Fe alloy,the Ce-added Zr_(2)(Fe_(1-x)Ni_(x))(x=0,0.15,0.3,0.5)alloys were prepared by magnetic levitation melting method.The effects of Ni substitution for Fe on the phase ...To improve the nitriding resistance of Zr_(2)Fe alloy,the Ce-added Zr_(2)(Fe_(1-x)Ni_(x))(x=0,0.15,0.3,0.5)alloys were prepared by magnetic levitation melting method.The effects of Ni substitution for Fe on the phase structure,hydrogen and nitrogen absorption properties of the alloys were investigated by X-ray diffraction,scanning electron microscopy and p-c isotherm measurements.The experimental results show that Ni substitution can effectively inhibit the formation of both α-Zr and ZrFe_(2) phases and promote the formation of C16 structure Zr_(2)(Fe,Ni)phase,causing Ni-substituted alloys to exhibit low nitrogen absorption rate and capacity.At 623 K under 0.5 MPa nitrogen pressure,the nitrogen absorption capacity of Ce-added Zr_(2)(Fe_(0.5)Ni_(0.5))alloy reaches to 0.8 mL/g,much lower than that of Zr_(2)Fe alloy(1.5 mL/g).Ni substitution decreases the crystal cell volume of the C_(16)Zr_(2)(Fe,Ni)phase,resulting in an increase in the hydrogen absorption equilibrium pressure.At 623 K under 0.05 MPa hydrogen pressure,the hydrogen absorption capacity decreases from 1.46 wt%of Zr_(2)Fe alloy to 1.41 wt%of Ce-added Zr_(2)(Fe_(0.5)Ni_(0.5))alloy.展开更多
The electrical performance of radomes on high-speed aircraft can be influenced by the thermal and mechanical loads produced during high-speed flight,which can affect the detection dis-tance and accuracy of the guidanc...The electrical performance of radomes on high-speed aircraft can be influenced by the thermal and mechanical loads produced during high-speed flight,which can affect the detection dis-tance and accuracy of the guidance system.This paper presents a new method that uses the Finite Difference Time Domain(FDTD)method to calculate the electrical performance of radomes under Thermo-Mechanical-Electrical(TME)coupling.This method can accurately characterize the effects of material dielectric temperature drift and structural deformation on the electrical performance of the radome under flight conditions,enabling high-precision full-wave calculations of the broadband electrical performance of the radome.The method initiates by utilizing a Finite Element Grid Model(FE-GM)of the radome to sequentially acquire the radome's response temperature field and structural deformation field through thermal and mechanical simulations.Subsequently,spatial mapping techniques are developed to accurately incorporate the dielectric temperature drift and structural deformation of the radome into its Yee grid Electromagnetic(EM)simulation model.A verification case was designed to test the proposed method,and the results confirmed its high computational accuracy.Additionally,the effectiveness and necessity of the method were further demonstrated by analyzing the electrical performance of a fused silica ceramic radome used on a high-speed aircraft.展开更多
Ionic liquid(IL)as the dispersant can help disperse the organic nanofillers to improve the performance of epoxy resin remarkably.However,the effect of IL on the electrical properties of epoxy composites is not well do...Ionic liquid(IL)as the dispersant can help disperse the organic nanofillers to improve the performance of epoxy resin remarkably.However,the effect of IL on the electrical properties of epoxy composites is not well documented.This comprehensive study consists of the preparation,material characterisation and systematical investigation of electrical properties of 1-Butyl-3-methylimidazole hexafluorophosphate-modified chitin fibre/epoxy composites.The findings show that introducing IL into a chitin/epoxy composite can minimise porosity defects and improve the compatibility between filler and matrix.However,a high concentration of IL induces severe charge injection into chitin/epoxy composites and internal electric field distortion.The addition of 0.75%–1.5%mass fraction IL results in maximum enhancement in the AC breakdown strength of the chitin/epoxy composite(by~71%)compared with the non-IL composites.The nonlinear conductivity and non-uniform charge injection phenomena of IL-modified composites can be attributed to the movement of radicals and anions due to the decomposition of IL.Through this study,it is highly expected that the organic filler dispersion in the epoxy matrix can be optimised by tuning IL to improve the insulation properties.展开更多
New energy storage devices such as batteries and supercapacitors are widely used in various fields because of their irreplaceable excellent characteristics.Because there are relatively few monitoring parameters and li...New energy storage devices such as batteries and supercapacitors are widely used in various fields because of their irreplaceable excellent characteristics.Because there are relatively few monitoring parameters and limited under-standing of their operation,they present problems in accurately predicting their state and controlling operation,such as state of charge,state of health,and early failure indicators.Poor monitoring can seriously affect the performance of energy storage devices.Therefore,to maximize the efficiency of new energy storage devices without damaging the equipment,it is important to make full use of sensing systems to accurately monitor important parameters such as voltage,current,temperature,and strain.These are highly related to their states.Hence,this paper reviews the sensing methods and divides them into two categories:embedded and non-embedded sensors.A variety of measurement methods used to measure the above parameters of various new energy storage devices such as batteries and super-capacitors are systematically summarized.The methods with different innovative points are listed,their advantages and disadvantages are summarized,and the application of optical fiber sensors is emphasized.Finally,the challenges and prospects for these studies are described.The intent is to encourage researchers in relevant fields to study the early warning of safety accidents from the root causes.展开更多
The Safety of The Intended Functionality(SOTIF)challenge represents the triggering condition by elements of a specific scenario and exposes the function limitation of an autonomous vehicle(AV),which leads to hazards.A...The Safety of The Intended Functionality(SOTIF)challenge represents the triggering condition by elements of a specific scenario and exposes the function limitation of an autonomous vehicle(AV),which leads to hazards.As for operationcontent-related features,the scenario is similar to AVs’SOTIF research and development.Therefore,scenario generation is a significant topic for SOTIF verification and validation procedure,especially in the simulation testing of AVs.Thus,in this paper,a well-designed scenario architecture is first defined,with comprehensive scenario elements,to present SOTIF trigger conditions.Then,considering complex traffic disturbance as trigger conditions,a novel SOTIF scenario generation method is developed.An indicator,also known as Scenario Potential Risk,is defined as the combination of the safety control intensity and the prior collision probability.This indicator helps identify critical scenarios in the proposed method.In addition,the corresponding vehicle motion models are established for general straight roads,curved roads,and safety assessment areas.As for the traffic participants’motion model,it is designed to construct the key dynamic events.To efficiently search for critical scenarios with the trigger of complex traffic flow,this scenario is encoded as genes and it is regenerated through selection,mutation,and crossover iteration processes,known as the Genetic Algorithm(GA).Experimental results show that the GA-based method could efficiently construct diverse and critical traffic scenarios,contributing to the construction of the SOTIF scenario library.展开更多
The Hedgehog(HH) signaling pathway plays important roles in gastrointestinal carcinogenesis and the gastrointestinal tumor microenvironment(TME). Aberrant HH signaling activation may accelerate the growth of gastroint...The Hedgehog(HH) signaling pathway plays important roles in gastrointestinal carcinogenesis and the gastrointestinal tumor microenvironment(TME). Aberrant HH signaling activation may accelerate the growth of gastrointestinal tumors and lead to tumor immune tolerance and drug resistance.The interaction between HH signaling and the TME is intimately involved in these processes, for example, tumor growth, tumor immune tolerance, inflammation, and drug resistance. Evidence indicates that inflammatory factors in the TME, such as interleukin 6(IL-6) and interferon-g(IFN-g), macrophages, and T cell-dependent immune responses, play a vital role in tumor growth by affecting the HH signaling pathway. Moreover, inhibition of proliferating cancer-associated fibroblasts(CAFs) and inflammatory factors can normalize the TME by suppressing HH signaling. Furthermore, aberrant HH signaling activation is favorable to both the proliferation of cancer stem cells(CSCs) and the drug resistance of gastrointestinal tumors. This review discusses the current understanding of the role and mechanism of aberrant HH signaling activation in gastrointestinal carcinogenesis, the gastrointestinal TME,tumor immune tolerance and drug resistance and highlights the underlying therapeutic opportunities.展开更多
Programmed cell death 4 (PDCD4) is a RNA-binding protein that acts as a tumor suppressor in many cancer types, including colorectal cancer (CRC). During CRC carcinogenesis, PDCD4 protein levels remarkably decrease...Programmed cell death 4 (PDCD4) is a RNA-binding protein that acts as a tumor suppressor in many cancer types, including colorectal cancer (CRC). During CRC carcinogenesis, PDCD4 protein levels remarkably decrease, but the underlying molecular mechanism for decreased PDCD4 expression is not fully understood. In this study, we performed bioinformatics analysis to identify miRNAs that potentially target PDCD4. We demonstrated miR-181b as a direct regulator of PDCD4. We further showed that activation of IL6/STAT3 signaling pathway increased miR-181b expression and conse- quently resulted in downregulation of PDCD4 in CRC cells. In addition, we investigated the biological effects of PDCD4 inhibition by miR-181b both in vitro and in vivo and found that miR-181b could promote cell proliferation and migration and suppress apoptosis in CRC cells and accelerate tumor growth in xenograft mice, potentially through targeting PDCD4. Taken toge- ther, this study highlights an oncomiR role for miR-181b in regulating PDCD4 in CRC and suggests that miR-181b may be a novel molecular therapeutic target for CRC.展开更多
The emergence of electronic devices has brought earth-shaking changes to people's life.However,an extemal power source may become indispensable to the electronie devices due to the limited capacity of batteries.As...The emergence of electronic devices has brought earth-shaking changes to people's life.However,an extemal power source may become indispensable to the electronie devices due to the limited capacity of batteries.As one of the possible solutions for the extermal power sources,the triboelectric nanogenerator(TENG)provides a novel idea to the increasing mumber of personal electronic devices.TENG is a new type of energy ollector,which has become a hot spot in the field of nanotechnology.It is widely used at the acquisition and conversion of mechan-ical enegy to electrice energy through the principle of electrostatic induction.On this basis,the TENG could be integrated with the energy stonage system into a self-powered system,W hich can supply power to the electronic devices and make them work continuously.In this review,TENG's basic structure as well as its working process and working mode are firstly discussed.The integration method of TENGs with enegy storage systems and the related research status are then introduced in detail.At the end of this paper,we put forward some problems and discuss the prospect in the future.展开更多
Infrared(IR)thermal imaging has aroused great interest due to its wide application in medical,scientific,and military fields.Most reported approaches for regulating thermal radiation are aimed to realize IR camouflage...Infrared(IR)thermal imaging has aroused great interest due to its wide application in medical,scientific,and military fields.Most reported approaches for regulating thermal radiation are aimed to realize IR camouflage and are not applicable to enhance thermal imaging.Here,we introduce a simple and effective method to process porous glass by femtosecond laser scanning,where distributed nanocavities and nanowires were produced,which caused improvement of the treated glass emissivity.The as-prepared sample possessed better IR thermal radiation performance but lower transmittance to visible light.We also demonstrated its applicability by placing it in different backgrounds,where the IR image temperature of laser-treated glass was closer to the actual environment,and this strategy may provide a new vision for enhanced thermal imaging.展开更多
基金This work was supported by National Natural Science Foundation of China(No.52105212)Sichuan Science and Technology Program(No.2023NSFSC0863)China Postdoctoral Science Foundation(No.2021M702712).
文摘Over the past two decades,superhydrophobic surfaces that are easily created have aroused considerable attention for their superior performances in various applications at room temperature.Nowadays,there is a growing demand in special fields for the development of surfaces that can resist wetting by high-temperature molten droplets(>1200°C)using facile design and fabrication strategies.Herein,bioinspired directional structures(BDSs)were prepared on Y2O3-stabilized ZrO2(YSZ)surfaces using femtosecond laser ablation.Benefiting from the anisotropic energy barriers,the BDSs featured with no additional modifiers showed a remarkable increase from 9.2°to 60°in the contact angle of CaO–MgO–Al2O3–SiO2(CMAS)melt and a 70.1%reduction in the spreading area of CMAS at 1250°C,compared with polished super-CMAS-melt-philic YSZ surfaces.Moreover,the BDSs demonstrated exceptional wetting inhibition even at 1400°C,with an increase from 3.3°to 31.3°in contact angle and a 67.9%decrease in spreading area.This work provides valuable insight and a facile preparation strategy for effectively inhibiting the wetting of molten droplets on super-melt-philic surfaces at extremely high temperatures.
文摘OBJECTIVE: To evaluate the predictive value of magnetic resonance cholangiography (MRC) in selected patients before laparoscopic cholecystectomy (LC). METHODS: Patients with risk factors for common bile duct (CBD) stones scheduled for elective LC from March 1999 to May 2001, underwent MRC followed by endoscopic retrograde cholangiography (ERC) to detect the stones and the accuracy of MRC. Selection of suspected patients was based on clinical, ultrasonographic, and laboratory criteria. RESULTS: During a 26-month period, a total of 267 patients were studied. Seventy-eight MRC identified patients were found to have CBD stones by ERC or laparoscopic cholangiography in the study. Seven of 78 patients were misdiagnosed as having CBD stones by MRC. In this study, MRC had a sensitivity of 100%, a specificity of 96.3%, a positive predictive value of 91.8%, and a negative predictive value of 100% for the detection of common bile duct stones. CONCLUSIONS: With the use of LC, ERC is frequently performed before LC to detect CBD stones; but it is invasive with a well-documented complication rate. MRC is a simple non-invasive method for preoperative screening for CBD stones in at-risk patients. In this study if ERC had been limited to patients with a positive MRC, it would have reduced the need for ERC by 68.2%, and the complications of preoperative examination would be minimized significantly.
基金This research is supported by National Natural Science Foundation of China(Nos.52075557,51805553)Natural Science Foundation of Hunan Province(No.2021JJ20067)+1 种基金The Science and Technology Innovation Program of Hunan Province(No.2021RC3011)Open access funding provided by Shanghai Jiao Tong University
文摘Versatile liquid manipulating surfaces combining patternable and controllable wettability have recently motivated considerable attention owing to their significant advantages in droplet-solid impacting behaviors,microdroplet self-removal,and liquid–liquid interface reaction applications.However,developing a facile and efficient method to fabricate these versatile surfaces remains an enormous challenge.In this paper,a strategy for the fabrication of liquid manipulating surfaces with patternable and controllable wettability on Polyimide(PI)film based on femtosecond laser thermal accumulation engineering is proposed.Because of its controllable micro-/nanostructures and chemical composition through adjusting the local thermal accumulation,the wettability of PI film can be tuned from superhydrophilicity(~3.6°)to superhydrophobicity(~151.6°).Furthermore,three diverse surfaces with patternable and heterogeneous wettability were constructed and various applications were successfully realized,including water transport,droplet arrays,and liquid wells.This work may provide a facile strategy for achieving patternable and controllable wettability efficiently and developing multifunctional liquid steering surfaces.
文摘At present,the domestic agriculture is facing challenges.Farmers' income is relatively low,and more and more rural young workers are divorced from the countryside to work in the relatively developed areas,which makes agricultural development caught in a vicious circle,so it is difficult to rationally allocate resources and increase industrial vitality.However,the new agricultural system of " Chongzhou Mode" has emerged to indicate a macro direction of agricultural development.In this paper,with " Chongzhou Mode" as the object of study,from the perspective of modern enterprise management,we elaborate some features of this mode such as corporate governance,land transfer cost internalization and human-based management,and explore the role of this mode in promoting employment,Internet +,and reducing market information asymmetry.Finally,we set forth the corresponding
基金the financial support from State Key Laboratory of Advanced Materials for Smart Sensing,GRINM Group Co.,Ltd.
文摘To improve the nitriding resistance of Zr_(2)Fe alloy,the Ce-added Zr_(2)(Fe_(1-x)Ni_(x))(x=0,0.15,0.3,0.5)alloys were prepared by magnetic levitation melting method.The effects of Ni substitution for Fe on the phase structure,hydrogen and nitrogen absorption properties of the alloys were investigated by X-ray diffraction,scanning electron microscopy and p-c isotherm measurements.The experimental results show that Ni substitution can effectively inhibit the formation of both α-Zr and ZrFe_(2) phases and promote the formation of C16 structure Zr_(2)(Fe,Ni)phase,causing Ni-substituted alloys to exhibit low nitrogen absorption rate and capacity.At 623 K under 0.5 MPa nitrogen pressure,the nitrogen absorption capacity of Ce-added Zr_(2)(Fe_(0.5)Ni_(0.5))alloy reaches to 0.8 mL/g,much lower than that of Zr_(2)Fe alloy(1.5 mL/g).Ni substitution decreases the crystal cell volume of the C_(16)Zr_(2)(Fe,Ni)phase,resulting in an increase in the hydrogen absorption equilibrium pressure.At 623 K under 0.05 MPa hydrogen pressure,the hydrogen absorption capacity decreases from 1.46 wt%of Zr_(2)Fe alloy to 1.41 wt%of Ce-added Zr_(2)(Fe_(0.5)Ni_(0.5))alloy.
文摘The electrical performance of radomes on high-speed aircraft can be influenced by the thermal and mechanical loads produced during high-speed flight,which can affect the detection dis-tance and accuracy of the guidance system.This paper presents a new method that uses the Finite Difference Time Domain(FDTD)method to calculate the electrical performance of radomes under Thermo-Mechanical-Electrical(TME)coupling.This method can accurately characterize the effects of material dielectric temperature drift and structural deformation on the electrical performance of the radome under flight conditions,enabling high-precision full-wave calculations of the broadband electrical performance of the radome.The method initiates by utilizing a Finite Element Grid Model(FE-GM)of the radome to sequentially acquire the radome's response temperature field and structural deformation field through thermal and mechanical simulations.Subsequently,spatial mapping techniques are developed to accurately incorporate the dielectric temperature drift and structural deformation of the radome into its Yee grid Electromagnetic(EM)simulation model.A verification case was designed to test the proposed method,and the results confirmed its high computational accuracy.Additionally,the effectiveness and necessity of the method were further demonstrated by analyzing the electrical performance of a fused silica ceramic radome used on a high-speed aircraft.
基金Key Project of Natural Science Foundation of Zhejiang Province,Grant/Award Number:LZ22E070001China Postdoctoral Science Fundation,Grant/Award Number:2023M733031。
文摘Ionic liquid(IL)as the dispersant can help disperse the organic nanofillers to improve the performance of epoxy resin remarkably.However,the effect of IL on the electrical properties of epoxy composites is not well documented.This comprehensive study consists of the preparation,material characterisation and systematical investigation of electrical properties of 1-Butyl-3-methylimidazole hexafluorophosphate-modified chitin fibre/epoxy composites.The findings show that introducing IL into a chitin/epoxy composite can minimise porosity defects and improve the compatibility between filler and matrix.However,a high concentration of IL induces severe charge injection into chitin/epoxy composites and internal electric field distortion.The addition of 0.75%–1.5%mass fraction IL results in maximum enhancement in the AC breakdown strength of the chitin/epoxy composite(by~71%)compared with the non-IL composites.The nonlinear conductivity and non-uniform charge injection phenomena of IL-modified composites can be attributed to the movement of radicals and anions due to the decomposition of IL.Through this study,it is highly expected that the organic filler dispersion in the epoxy matrix can be optimised by tuning IL to improve the insulation properties.
基金funded by the Youth Fund of Shandong Province Natural Science Foundation grant number ZR2020QE212Key Projects of Shandong Province Natural Science Foundation grant number ZR2020KF020+2 种基金the Guangdong Provincial Key Lab of Green Chemical Product Technology grant number GC 202111Zhejiang Province Natural Science Foundation grant number LY22E070007National Natural Science Foundation of China grant number 52007170.
文摘New energy storage devices such as batteries and supercapacitors are widely used in various fields because of their irreplaceable excellent characteristics.Because there are relatively few monitoring parameters and limited under-standing of their operation,they present problems in accurately predicting their state and controlling operation,such as state of charge,state of health,and early failure indicators.Poor monitoring can seriously affect the performance of energy storage devices.Therefore,to maximize the efficiency of new energy storage devices without damaging the equipment,it is important to make full use of sensing systems to accurately monitor important parameters such as voltage,current,temperature,and strain.These are highly related to their states.Hence,this paper reviews the sensing methods and divides them into two categories:embedded and non-embedded sensors.A variety of measurement methods used to measure the above parameters of various new energy storage devices such as batteries and super-capacitors are systematically summarized.The methods with different innovative points are listed,their advantages and disadvantages are summarized,and the application of optical fiber sensors is emphasized.Finally,the challenges and prospects for these studies are described.The intent is to encourage researchers in relevant fields to study the early warning of safety accidents from the root causes.
基金the financial support of the National Science Foundation of China Project:U1964203 and 52072215National key R&D Program of China:2020YFB1600303.
文摘The Safety of The Intended Functionality(SOTIF)challenge represents the triggering condition by elements of a specific scenario and exposes the function limitation of an autonomous vehicle(AV),which leads to hazards.As for operationcontent-related features,the scenario is similar to AVs’SOTIF research and development.Therefore,scenario generation is a significant topic for SOTIF verification and validation procedure,especially in the simulation testing of AVs.Thus,in this paper,a well-designed scenario architecture is first defined,with comprehensive scenario elements,to present SOTIF trigger conditions.Then,considering complex traffic disturbance as trigger conditions,a novel SOTIF scenario generation method is developed.An indicator,also known as Scenario Potential Risk,is defined as the combination of the safety control intensity and the prior collision probability.This indicator helps identify critical scenarios in the proposed method.In addition,the corresponding vehicle motion models are established for general straight roads,curved roads,and safety assessment areas.As for the traffic participants’motion model,it is designed to construct the key dynamic events.To efficiently search for critical scenarios with the trigger of complex traffic flow,this scenario is encoded as genes and it is regenerated through selection,mutation,and crossover iteration processes,known as the Genetic Algorithm(GA).Experimental results show that the GA-based method could efficiently construct diverse and critical traffic scenarios,contributing to the construction of the SOTIF scenario library.
基金supported by Scientific Research Project of Shanghai Health and Family Planning Committee (Grant No.201640017, China)National Science and Technology Major Project (Grant No. 2017ZX09304030, China)Shanghai Science and Technology Funds (Grant No. 19ZR1456100, China)。
文摘The Hedgehog(HH) signaling pathway plays important roles in gastrointestinal carcinogenesis and the gastrointestinal tumor microenvironment(TME). Aberrant HH signaling activation may accelerate the growth of gastrointestinal tumors and lead to tumor immune tolerance and drug resistance.The interaction between HH signaling and the TME is intimately involved in these processes, for example, tumor growth, tumor immune tolerance, inflammation, and drug resistance. Evidence indicates that inflammatory factors in the TME, such as interleukin 6(IL-6) and interferon-g(IFN-g), macrophages, and T cell-dependent immune responses, play a vital role in tumor growth by affecting the HH signaling pathway. Moreover, inhibition of proliferating cancer-associated fibroblasts(CAFs) and inflammatory factors can normalize the TME by suppressing HH signaling. Furthermore, aberrant HH signaling activation is favorable to both the proliferation of cancer stem cells(CSCs) and the drug resistance of gastrointestinal tumors. This review discusses the current understanding of the role and mechanism of aberrant HH signaling activation in gastrointestinal carcinogenesis, the gastrointestinal TME,tumor immune tolerance and drug resistance and highlights the underlying therapeutic opportunities.
文摘Programmed cell death 4 (PDCD4) is a RNA-binding protein that acts as a tumor suppressor in many cancer types, including colorectal cancer (CRC). During CRC carcinogenesis, PDCD4 protein levels remarkably decrease, but the underlying molecular mechanism for decreased PDCD4 expression is not fully understood. In this study, we performed bioinformatics analysis to identify miRNAs that potentially target PDCD4. We demonstrated miR-181b as a direct regulator of PDCD4. We further showed that activation of IL6/STAT3 signaling pathway increased miR-181b expression and conse- quently resulted in downregulation of PDCD4 in CRC cells. In addition, we investigated the biological effects of PDCD4 inhibition by miR-181b both in vitro and in vivo and found that miR-181b could promote cell proliferation and migration and suppress apoptosis in CRC cells and accelerate tumor growth in xenograft mice, potentially through targeting PDCD4. Taken toge- ther, this study highlights an oncomiR role for miR-181b in regulating PDCD4 in CRC and suggests that miR-181b may be a novel molecular therapeutic target for CRC.
基金This work was supported by the Project of Shandong Province Higher Educational Science and Technology Program(No.J18KA316)Liaoning Science and Technology Plan(No.20180550573)+1 种基金the Shandong Science and Technology Development Plan(No.2019GGX104019)Guangdong Basic and Applied Basic Research Foundation(No.2019A1515110706).
文摘The emergence of electronic devices has brought earth-shaking changes to people's life.However,an extemal power source may become indispensable to the electronie devices due to the limited capacity of batteries.As one of the possible solutions for the extermal power sources,the triboelectric nanogenerator(TENG)provides a novel idea to the increasing mumber of personal electronic devices.TENG is a new type of energy ollector,which has become a hot spot in the field of nanotechnology.It is widely used at the acquisition and conversion of mechan-ical enegy to electrice energy through the principle of electrostatic induction.On this basis,the TENG could be integrated with the energy stonage system into a self-powered system,W hich can supply power to the electronic devices and make them work continuously.In this review,TENG's basic structure as well as its working process and working mode are firstly discussed.The integration method of TENGs with enegy storage systems and the related research status are then introduced in detail.At the end of this paper,we put forward some problems and discuss the prospect in the future.
基金This work was supported by the National Natural Science Foundation of China(Nos.52075557 and 51805553)Natural Science Foundation of Hunan Province(No.2021JJ20067)+1 种基金Science and Technology Innovation Program of Hunan Province(No.2021RC3011)We thank Wuhan Huaray Ultrafast Fiber Laser Technology Co,Ltd.for their support.
文摘Infrared(IR)thermal imaging has aroused great interest due to its wide application in medical,scientific,and military fields.Most reported approaches for regulating thermal radiation are aimed to realize IR camouflage and are not applicable to enhance thermal imaging.Here,we introduce a simple and effective method to process porous glass by femtosecond laser scanning,where distributed nanocavities and nanowires were produced,which caused improvement of the treated glass emissivity.The as-prepared sample possessed better IR thermal radiation performance but lower transmittance to visible light.We also demonstrated its applicability by placing it in different backgrounds,where the IR image temperature of laser-treated glass was closer to the actual environment,and this strategy may provide a new vision for enhanced thermal imaging.