A novel copper metabolism-related signature model for predicting the prognosis,target drugs,and immunotherapy in stomach adenocarcinoma

Stomach adenocarcinoma(STAD)is one of the most common gastric neoplasms with a high death rate.Therefore,there is an urgent need to propose an efficient therapy for STAD.Copper plays key roles in regulating the distribution of immune cells and affecting the tumor immune escape,and may be a novel indicator of immunotherapy in STAD.However,the specific impact of copper metabolism-related genes(CMRGs)on the patient’s prognosis,tumor microenvironment,and immunotherapeutic response remains unelucidated.

Design of readout electronics based on peak-holding circuit and multiplexer for a fast neutron spectrometer

Background Fast neutron detection is meaningful in many research fields such as space environment monitoring.A scintillating fiber array model for fast neutron detection was proposed and developed in 1980s.Aerospace applications of the model require electronics in small size.Purpose To design a dedicated electronic system to readout and process the 384-channel signals from scintillating fiber array,and to use the designed system to fabricate a neutron detector for aerospace applications.Methods With the method of nuclear recoil,fast neutron is detected by tracking recoil proton of n–p scatter in scintillating plastic fibers.Using the peak-holding circuits and multiplexers,the system size and power consumption were reduced.Results The detector fabricated with the designed system,had 34 cm×34 cm×27 cm mechanical size,20.4 kg weight,and 30.05W power consumption.Comparing to traditional waveform sampling electronics,the designed electronics was highly integrated and had a small size.The readout electronics also gave a better energy resolution of 39%in neutron detection,while the energy resolution was 43%in previous version.Conclusion In this study,a highly integrated readout electronic system was designed and verified.The detector using the system gave good performance.The designed electronics had potential development in fast neutron detection and other high energy physics detection system.

Development of a fast neutron spectrometer based on a plastic fiber array

Objective A three-dimensional position-sensitive fast neutron spectrometer is designed to measure fast neutron spectrum over 10 MeV.Methods The detector consists of a 16×16 mutually perpendicular plastic scintillation fiber array coupled to 2×2 Hamamatsu H8500C position-sensitive photomultiplier tubes by optical fibers.The fiber array is fabricated with 0.5 mm×3 mm fibers and 3-mm square fibers.Results Due to the combined application of different sizes of fibers,the detector can broaden energy dynamic range and meanwhile have good detection efficiency.The method of the combined application of different sizes of plastic fibers in the array may provide a solution to measure wider energy range of solar neutrons.Conclusion In this paper,we used FLUKA to simulate the performance of the detector model and report the results of experimental studies with neutrons from a pulsed D-T neutron.