Objective: To study the effect of dexmedetomidine combined with sevoflurane on myocardial injury and oxidative stress response after non-cardiac surgery in patients with coronary heart disease. Methods: A total of 104...Objective: To study the effect of dexmedetomidine combined with sevoflurane on myocardial injury and oxidative stress response after non-cardiac surgery in patients with coronary heart disease. Methods: A total of 104 patients with coronary heart disease who received abdominal operation in the First Affiliated Hospital of Guangzhou Medical University between March 2015 and February 2017 were selected and randomly divided into control group (group C), dexmedetomidine group (group D), sevoflurane group (group S) and dexmedetomidine +sevoflurane group (group D+S), the anesthesia was observed, and serum levels of myocardial injury markers, vasoactive molecules and oxidative stress indexes were detected before operation and 24 h after operation. Results: The extubation time, PACU staying time and ICU staying time as well as the incidence of postoperative arrhythmias and dysarteriotony were not significantly different among the four groups;24 h after the surgery, H-FABP, cTnI, CK-MB, Myo, NT-proBNP, NT-proANP, AT-II, ALD, IMA and MDA contents in serum as well as Nrf-2 and ARE expression in peripheral blood of four groups of patients were significantly higher than those before operation, H-FABP, cTnI, CK-MB, Myo, NT-proBNP, NT-proANP, AT-II, ALD, IMA and MDA contents in serum as well as Nrf-2 and ARE expression in peripheral blood of group D, group S and group D+S were significantly lower than those of group C, and H-FABP, cTnI, CK-MB, Myo, NT-proBNP, NT-proANP, AT-II, ALD, IMA and MDA contents in serum as well as Nrf-2 and ARE expression in peripheral blood of group D+S were significantly lower than those of group D and group S. Conclusion: Dexmedetomidine combined with sevoflurane can reduce the myocardial injury and oxidative stress response after non-cardiac surgery in patients with coronary heart disease.展开更多
文摘Objective: To study the effect of dexmedetomidine combined with sevoflurane on myocardial injury and oxidative stress response after non-cardiac surgery in patients with coronary heart disease. Methods: A total of 104 patients with coronary heart disease who received abdominal operation in the First Affiliated Hospital of Guangzhou Medical University between March 2015 and February 2017 were selected and randomly divided into control group (group C), dexmedetomidine group (group D), sevoflurane group (group S) and dexmedetomidine +sevoflurane group (group D+S), the anesthesia was observed, and serum levels of myocardial injury markers, vasoactive molecules and oxidative stress indexes were detected before operation and 24 h after operation. Results: The extubation time, PACU staying time and ICU staying time as well as the incidence of postoperative arrhythmias and dysarteriotony were not significantly different among the four groups;24 h after the surgery, H-FABP, cTnI, CK-MB, Myo, NT-proBNP, NT-proANP, AT-II, ALD, IMA and MDA contents in serum as well as Nrf-2 and ARE expression in peripheral blood of four groups of patients were significantly higher than those before operation, H-FABP, cTnI, CK-MB, Myo, NT-proBNP, NT-proANP, AT-II, ALD, IMA and MDA contents in serum as well as Nrf-2 and ARE expression in peripheral blood of group D, group S and group D+S were significantly lower than those of group C, and H-FABP, cTnI, CK-MB, Myo, NT-proBNP, NT-proANP, AT-II, ALD, IMA and MDA contents in serum as well as Nrf-2 and ARE expression in peripheral blood of group D+S were significantly lower than those of group D and group S. Conclusion: Dexmedetomidine combined with sevoflurane can reduce the myocardial injury and oxidative stress response after non-cardiac surgery in patients with coronary heart disease.
