Cluster analysis of Qian Jing-hua’s experience in treatment of lung cancer

Objective to analyze the rule of drug use in treating lung cancer disease by using the theory of fuzheng and dispelling evil in traditional Chinese medicine by data mining.Methods:By following Dr.Qianjinghua's outpatient department,we collected the prescription for the treatment of lung cancer by using frequency analysis,association rule analysis and cluster analysis.Results:746 prescriptions were included in this study,commonly used drugs 170 flavors.Traditional Chinese medicine with a high frequency of use were Baihuasheshecao(Hedyotis diffusa),Maorenshen(Actinidia valvata Dunn),Shishangbai(Selaginella doederleinii Hieron),Shijianchuan(Salvia chinensis Benth),Huangqi(Astragali Radix),Sanyeqing(Tetrastlgma hemsleyanum),Baimaoteng(HerbaSolani),Zhuling(Polyporus),Nvzhenzi(Ligustrum lucidum Ait)etc.Through the analysis of association rule,we find out the core prescription according to the support degree(10%,20%,30%)and the confidence degree,and set the correlation degree to 8 and punishment degree to 2.Finally:The core prescription efficacy of the drug group was analyzed and the theoretical connotation of preventive treatment of disease was obtained.Conclusion:The core prescription of preventive treatment of disease is to clear up heat and detoxification on the basis of strengthening the spleen,replenishing qi and tonifying kidney.The use of blood supplements and yin tonics throughout the course is reduced during treatments.The treatments also pay attention to the function of spleen and stomach of lung cancer patients,and adjust heat and detoxification force according to different conditions of patients and pay attention to the relief of patients’emotions.

The molecular mechanism of meridian qi sensory transmission by heat-sensitive moxibustion in the treatment of cerebral infarction

Background:To explore the potential mechanism of thermal moxibustion in the treatment of i schemic strok e by using the method of network pharmacology and to partially explain the mechanism of acupoint meridian qi sense transmission.Methods:In this project,a training set was formed by researching the intersection of the reported components of M ugwort leaves that entered the blood after combustion and obtained the targets of heat-sensitive moxibustion meridian qi sensing and thermal effect by querying the literature.The Encyclopedia of Tr ad itional Chinese Medicine is used to search and screen the highly active chemical constituents of Artemisia argyi to predict potential targets;search i schemic strok e-related targets through GeneCards,O nline Mendelian Inheritance in Man,Drugbank databases.Gene Oncology functional analysis and Kyoto Encyclopedia of Genes and Genomes signaling pathway enrichment analysis were performed on the potential targets of the blood components of Artemisia argyi and molecular docking simulated the binding activity of key candidate active components and core genes.Results:192 ischemic stroke disease targets with r elevance score greater than 10 were screened out for analysis.Through the database Encyclopedia of Tr ad itional Chinese Medicine query of the action targets(243)of Mugwort leaves and the intersection of heat-sensitive moxibustion effect targets and ischemic stroke-related targets,a Venn diagram was drawn and a total of 17 were obtained.Finally,the effective components of Mugwort leaves into the blood were screened out.Five main volatile components were molecularly docked with 17 targets and 9 targets of acupoint meridian gas sensing/thermal effect.The docking results showed that the main volatile components showed good affinities for binding to key targets,respectively.Conclusion:Using the characteristics of“multi-component-multi-target-multi-pathway”of traditional Chinese medicine,the potential mechanism of action of Artemisia argyi in the treatment of i schemic strok e is explored,which provides a certain basis for the follow-up scientific research and clinical application of Artemisia argyi in the treatment of IS.