B cells are a heterogeneous population,which have distinct functions of antigen presentation,activating T cells,and secreting antibodies,cytokines as well as protease.It is supposed that the balance among these B cell...B cells are a heterogeneous population,which have distinct functions of antigen presentation,activating T cells,and secreting antibodies,cytokines as well as protease.It is supposed that the balance among these B cells subpopulation(resting B cells,activated B cells,Bregs,and other differentiated B cells)will determine the ultimate role of B cells in tumor immunity.There has been increasing evidence supporting opposite roles of B cells in tumor immunity,though there are no general acceptable phenotypes for them.Recent years,a new designated subset of B cells identified as Bregs has emerged from immunosuppressive and/or regulatory functions in tumor immune responses.Therefore,transferring activated B cells would be possible to become a promising strategy against tumor via conquering the immunosuppressive status of B cells in future.Understanding the potential mechanism of double-edge role of B cells will help researchers utilize activated B cells to improve their anti-tumor response.Moreover,the molecular pathways related to B cell differentiation are involved in its tumor-promoting effect,such as NF-κB,STAT3,BTK.So,we review the molecular and signaling pathway mechanisms of B cells involved in both tumor-promoting and tumor-suppressive immunity,in order to help researchers optimize B cells to fight cancer better.展开更多
文摘B cells are a heterogeneous population,which have distinct functions of antigen presentation,activating T cells,and secreting antibodies,cytokines as well as protease.It is supposed that the balance among these B cells subpopulation(resting B cells,activated B cells,Bregs,and other differentiated B cells)will determine the ultimate role of B cells in tumor immunity.There has been increasing evidence supporting opposite roles of B cells in tumor immunity,though there are no general acceptable phenotypes for them.Recent years,a new designated subset of B cells identified as Bregs has emerged from immunosuppressive and/or regulatory functions in tumor immune responses.Therefore,transferring activated B cells would be possible to become a promising strategy against tumor via conquering the immunosuppressive status of B cells in future.Understanding the potential mechanism of double-edge role of B cells will help researchers utilize activated B cells to improve their anti-tumor response.Moreover,the molecular pathways related to B cell differentiation are involved in its tumor-promoting effect,such as NF-κB,STAT3,BTK.So,we review the molecular and signaling pathway mechanisms of B cells involved in both tumor-promoting and tumor-suppressive immunity,in order to help researchers optimize B cells to fight cancer better.
