Sonodynamic therapy(SDT)exhibits noninvasive and accuracy in cancer treatment,and has aroused widespread attention.However,the low quantum yield of inorganic sonosensitizers under ultrasound(US)stimulation leads to un...Sonodynamic therapy(SDT)exhibits noninvasive and accuracy in cancer treatment,and has aroused widespread attention.However,the low quantum yield of inorganic sonosensitizers under ultrasound(US)stimulation leads to unsatisfactory efficacy.In this work,an urchin-like piezoelectric ZnSnO_(3)/Cu_(3)P p-n heterojunction was constructed as an efficient sonosensitizer for enhanced SDT.The p-n heterojunction formation narrows the band bandgap and increases the piezoelectric property,which contribute to the promotion of carrier separation and suppression of carrier recombination,resulting in enhanced SDT.Moreover,under tumor microenvironment(TME)with over produced H_(2)O_(2)and glutathione(GSH),Cu_(3)P NNs induce chemodynamic therapy(CDT)by initiating a Fenton-like reaction and depleting GSH,leading to increased cellular oxidative damage.With the combination effect,the Zn Sn O_(3)/Cu_(3)P heterojunction demonstrates a 70%tumor growth inhibition rate in 4T1 tumor mice model.This piezoelectric heterojunction achieves the combined treatment of SDT and CDT,and opens new possibilities for the application of SDT in tumor therapy.展开更多
Photocaged fluorophores with photoactivatable characteristics presented important applications in imaging the biological structures and processes.Taking advantage of their super-resolution imaging merits to manipulate...Photocaged fluorophores with photoactivatable characteristics presented important applications in imaging the biological structures and processes.Taking advantage of their super-resolution imaging merits to manipulate and visualize anti-cancer treatment is always a goal of modern clinical medicine.Traditional photodynamic therapy(PDT) is a noninvasive treatment but limited in intracellular oxygen content.Type I PDT and photoacid therapy(PAT) are two effective supplements of traditional PDT especially in hypoxic condition.Herein,a novel white-light-driven fluorescence switch(7H-dibenzo[c,g]carbazol-7-yl)(2-iodophenyl)methanone(2IB) was designed and synthesized as an unprecedent “all in one” platform for stochastic optical reconstruction microscopy(STORM) imaging guided Type Ⅰ/Ⅱ PDT and PAT.The experimental and theoretical studies revealed that the working mechanism is based on two competing paths under excitation:photosensitization and photocyclization reaction.Efficient intersystem crossing(ISC) ensured the generation of reactive oxygen species(ROS) for PDT,while low energy barrier facilitated the photocyclization reaction that simultaneously yielded emissive fluorophores(2IBC) and H^(+) for super-resolution imaging and photoacid,respectively.Impressively,the fluorescent intensity of mitochondria-targeted 2IBC was positively correlated with treatment efficacy,which is beneficial to spatiotemporally visualized therapeutic process and outcome.As a result,superior anti-tumor performance was achieved in vitro and in vivo.This contribution provided a multifunctional nanodrug paradigm for multimode cancer diagnosis and treatment.展开更多
It is important to regulate the concentration of reactive oxygen species(ROS)in cells since they play important roles in metabolism.Thus,developing nanoreagents to control the ROS is critical.Herein,tellurium-doped ca...It is important to regulate the concentration of reactive oxygen species(ROS)in cells since they play important roles in metabolism.Thus,developing nanoreagents to control the ROS is critical.Herein,tellurium-doped carbon quantum dots(Te-CDs)were developed by a simple and efficient hydrothermal method,which can scavenge H2O2 to protect cells under ambient condition,but generateáOH under 808 nm irradiation as photodynamic application.This contribution presented a kind of novel CDs with dual-functions,which can potentially regulate ROS under different conditions.展开更多
基金supported by the National Nature Science Foundation(No.82072065)the Fundamental Research Funds for the Central Universities(No.E2EG6802X2)the National Youth Talent Support Program。
文摘Sonodynamic therapy(SDT)exhibits noninvasive and accuracy in cancer treatment,and has aroused widespread attention.However,the low quantum yield of inorganic sonosensitizers under ultrasound(US)stimulation leads to unsatisfactory efficacy.In this work,an urchin-like piezoelectric ZnSnO_(3)/Cu_(3)P p-n heterojunction was constructed as an efficient sonosensitizer for enhanced SDT.The p-n heterojunction formation narrows the band bandgap and increases the piezoelectric property,which contribute to the promotion of carrier separation and suppression of carrier recombination,resulting in enhanced SDT.Moreover,under tumor microenvironment(TME)with over produced H_(2)O_(2)and glutathione(GSH),Cu_(3)P NNs induce chemodynamic therapy(CDT)by initiating a Fenton-like reaction and depleting GSH,leading to increased cellular oxidative damage.With the combination effect,the Zn Sn O_(3)/Cu_(3)P heterojunction demonstrates a 70%tumor growth inhibition rate in 4T1 tumor mice model.This piezoelectric heterojunction achieves the combined treatment of SDT and CDT,and opens new possibilities for the application of SDT in tumor therapy.
基金supported by Beijing Natural Science Foundation(Z210017)the National Natural Science Foundation of China(21774130 and 51925306)the Science and Technology Innovation Commission of Shenzhen(JCYJ20220530150604009)。
基金supported by the Beijing Natural Science Foundation(Z210017)the National Natural Science Foundation of China(21774130,51925306)+4 种基金the National Key R&D Program of China(2018FYA 0305800)the Key Research Program of Frontier Sciences,Chinese Academy of Sciences(QYZDB-SSW-JSC046)the Strategic Priority Research ProgramChinese Academy of Sciences(XDB28000000)University of Chinese Academy of Sciences。
文摘Photocaged fluorophores with photoactivatable characteristics presented important applications in imaging the biological structures and processes.Taking advantage of their super-resolution imaging merits to manipulate and visualize anti-cancer treatment is always a goal of modern clinical medicine.Traditional photodynamic therapy(PDT) is a noninvasive treatment but limited in intracellular oxygen content.Type I PDT and photoacid therapy(PAT) are two effective supplements of traditional PDT especially in hypoxic condition.Herein,a novel white-light-driven fluorescence switch(7H-dibenzo[c,g]carbazol-7-yl)(2-iodophenyl)methanone(2IB) was designed and synthesized as an unprecedent “all in one” platform for stochastic optical reconstruction microscopy(STORM) imaging guided Type Ⅰ/Ⅱ PDT and PAT.The experimental and theoretical studies revealed that the working mechanism is based on two competing paths under excitation:photosensitization and photocyclization reaction.Efficient intersystem crossing(ISC) ensured the generation of reactive oxygen species(ROS) for PDT,while low energy barrier facilitated the photocyclization reaction that simultaneously yielded emissive fluorophores(2IBC) and H^(+) for super-resolution imaging and photoacid,respectively.Impressively,the fluorescent intensity of mitochondria-targeted 2IBC was positively correlated with treatment efficacy,which is beneficial to spatiotemporally visualized therapeutic process and outcome.As a result,superior anti-tumor performance was achieved in vitro and in vivo.This contribution provided a multifunctional nanodrug paradigm for multimode cancer diagnosis and treatment.
基金the National Natural Foundation of China(21774130 and 51925306)National Key R&D Program of China(2018FYA0305800)+4 种基金the Key Research Program of Frontier Sciences,Chinese Academy of Sciences(QYZDB-SSW-JSC046)Key Research Program of the Chinese Academy of Sciences(XDPB08-2)the Strategic Priority Research Program of Chinese Academy of Sciences(XDB28000000)the International Partnership Program of Chinese Academy of Sciences(211211KYSB20170014)University of Chinese Academy of Sciences。
文摘It is important to regulate the concentration of reactive oxygen species(ROS)in cells since they play important roles in metabolism.Thus,developing nanoreagents to control the ROS is critical.Herein,tellurium-doped carbon quantum dots(Te-CDs)were developed by a simple and efficient hydrothermal method,which can scavenge H2O2 to protect cells under ambient condition,but generateáOH under 808 nm irradiation as photodynamic application.This contribution presented a kind of novel CDs with dual-functions,which can potentially regulate ROS under different conditions.
