A rapid and sensitive method for analyzing trace b-blockers in complex biological samples,which involved magnetic solid-phase extraction(MSPE)coupled with Fourier transform ion cyclotron resonance mass spectrometry(FT...A rapid and sensitive method for analyzing trace b-blockers in complex biological samples,which involved magnetic solid-phase extraction(MSPE)coupled with Fourier transform ion cyclotron resonance mass spectrometry(FTICR-MS),was developed.Novel nanosilver-functionalized magnetic nanoparticles with an interlayer of poly(3,4-dihydroxyphenylalanine)(polyDOPA@Ag-MNPs)were synthesized and used as MSPE adsorbents to extract trace b-blockers from biological samples.After extraction,the analytes loaded on the polyDOPA@Ag-MNPs were desorbed using an organic solvent and analyzed by FTICR-MS.The method was rapid and sensitive,with a total detection procedure of less than 10 min as well as limits of detection and quantification in the ranges of 3.5-6.8 pg/mL and 11.7-22.8 pg/mL,respectively.The accuracy of the method was also desirable,with recoveries ranging from 80.9%to 91.0%following the detection of analytes in human blood samples.All the experimental results demonstrated that the developed MSPE-FTICR-MS method was suitable for the rapid and sensitive analysis of trace b-blockers in complex biological samples.展开更多
The aim of this paper is to prove a new version of the Riesz-Thorin interpolation theorem on L^(P)(C,H).In the sense of Cullen-regular,we show Hadamard’s three-lines theorem by means of the Maximum modulus principle ...The aim of this paper is to prove a new version of the Riesz-Thorin interpolation theorem on L^(P)(C,H).In the sense of Cullen-regular,we show Hadamard’s three-lines theorem by means of the Maximum modulus principle on a symmetric slice domain.In addition,two applications of the Riesz-Thorin theorem are presented.Finally,we investigate two kinds of Calderón’s complex interpolation methods in LP(C,H).展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.:21976168,22127810,and 22004113)Key Research and Development Program of Guangdong Province(Grant No.:2020B1111350002)+1 种基金Guangdong Basic and Applied Basic Research Foundation(Grant No.:2019A1515110420)GDAS0 Project of Science and Technology Development(Grant No.:2021GDASYL-20210103034).
文摘A rapid and sensitive method for analyzing trace b-blockers in complex biological samples,which involved magnetic solid-phase extraction(MSPE)coupled with Fourier transform ion cyclotron resonance mass spectrometry(FTICR-MS),was developed.Novel nanosilver-functionalized magnetic nanoparticles with an interlayer of poly(3,4-dihydroxyphenylalanine)(polyDOPA@Ag-MNPs)were synthesized and used as MSPE adsorbents to extract trace b-blockers from biological samples.After extraction,the analytes loaded on the polyDOPA@Ag-MNPs were desorbed using an organic solvent and analyzed by FTICR-MS.The method was rapid and sensitive,with a total detection procedure of less than 10 min as well as limits of detection and quantification in the ranges of 3.5-6.8 pg/mL and 11.7-22.8 pg/mL,respectively.The accuracy of the method was also desirable,with recoveries ranging from 80.9%to 91.0%following the detection of analytes in human blood samples.All the experimental results demonstrated that the developed MSPE-FTICR-MS method was suitable for the rapid and sensitive analysis of trace b-blockers in complex biological samples.
基金supported by the Innovation Research for the Postgrad-uates of Guangzhou University(2020GDJC-D06)supported by the National Natural Science Foundation of China(12071229)。
文摘The aim of this paper is to prove a new version of the Riesz-Thorin interpolation theorem on L^(P)(C,H).In the sense of Cullen-regular,we show Hadamard’s three-lines theorem by means of the Maximum modulus principle on a symmetric slice domain.In addition,two applications of the Riesz-Thorin theorem are presented.Finally,we investigate two kinds of Calderón’s complex interpolation methods in LP(C,H).
