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Aldh2 deficiency plays a dual role in lung tumorigenesis and tumor progression
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作者 Hongjia Zhang Xueqian Sun +19 位作者 Zhanming li Tingting liu Fang Zhang Xinyu Meng kaimi li Jianhua Xu Wei He Bo Jing Tong Wang Na Ni Beibei Sun Feng Yao Yadi Wu Qi Wang Jing Du Eugene Y.Chin Binhua P.Zhou Ping Jiang lishun Wang Jiong Deng 《Genes & Diseases》 SCIE CSCD 2024年第3期144-147,共4页
Alcohol consumption contributes to global mortality and cancer development.Acetaldehyde(ACE),the oxidized metabolite of alcohol,is highly reactive towards DNA,resulting in DNA adducts.ACE can be detoxified to acetate ... Alcohol consumption contributes to global mortality and cancer development.Acetaldehyde(ACE),the oxidized metabolite of alcohol,is highly reactive towards DNA,resulting in DNA adducts.ACE can be detoxified to acetate by acetaldehyde dehydrogenase type 2(ALDH2).ALDH2 deficiency can lead to ACE accumulation and DNA damage. 展开更多
关键词 MORTALITY DAMAGE ALDH2
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