The power generated by flexible wearable devices(FWDs)is normally insufficient to eradicate bacteria,and many conventional antibacterial strategies are also not suitable for flexible and wearable applications because ...The power generated by flexible wearable devices(FWDs)is normally insufficient to eradicate bacteria,and many conventional antibacterial strategies are also not suitable for flexible and wearable applications because of the strict mechanical and electrical requirements.Here,polypyrrole(PPy),a conductive polymer with a high mass density,is used to form a nanostructured surface on FWDs for antibacterial purposes.The conductive films with PPy nanorods(PNRs)are found to sterilize 98.2±1.6%of Staphylococcus aureus and 99.6±0.2%of Escherichia coli upon mild electrification(1 V).Bacteria killing stems from membrane stress produced by the PNRs and membrane depolarization caused by electrical neutralization.Additionally,the PNR films exhibit excellent biosafety and electrical stability.The results represent pioneering work in fabricating antibacterial components for FWDs by comprehensively taking into consideration the required conductivity,mechanical properties,and biosafety.展开更多
As an important phenomenon to monitor disease development,cell signaling usually takes place at the interface between organisms/cells or between organisms/cells and abiotic materials.Therefore,finding a strategy to bu...As an important phenomenon to monitor disease development,cell signaling usually takes place at the interface between organisms/cells or between organisms/cells and abiotic materials.Therefore,finding a strategy to build the specific biomedical interfaces will help regulate information transmission and produce better therapeutic results to benefit patients.In the past decades,plasmas containing energetic and active species have been employed to construct various interfaces to meet biomedical demands such as bacteria inactivation,tissue regeneration,cancer therapy,and so on.Based on the potent functions of plasma modified surfaces,this mini-review is aimed to summarize the state-of-art plasma-activated interfaces and provide guidance to researchers to select the proper plasma and processing conditions to design and prepare interfaces with the optimal biological and related functions.After a brief introduction,plasma-activated interfaces are described and categorized according to different criteria including direct plasma-cells interfaces and indirect plasma-material-cells interfaces and recent research activities on the application of plasma-activated interfaces are described.The authors hope that this mini-review will spur interdisciplinary research efforts in this important area and expedite associated clinical applications.展开更多
基金The authors acknowledge the financial support from Hong Kong PDFS-RGC Postdoctoral Fellowship Scheme(PDFS2122-1S08 and CityU 9061014)Hong Kong HMRF(Health and Medical Research Fund)(2120972 and CityU 9211320)National Natural Science Foundation of China(81903057 and 31922040).
文摘The power generated by flexible wearable devices(FWDs)is normally insufficient to eradicate bacteria,and many conventional antibacterial strategies are also not suitable for flexible and wearable applications because of the strict mechanical and electrical requirements.Here,polypyrrole(PPy),a conductive polymer with a high mass density,is used to form a nanostructured surface on FWDs for antibacterial purposes.The conductive films with PPy nanorods(PNRs)are found to sterilize 98.2±1.6%of Staphylococcus aureus and 99.6±0.2%of Escherichia coli upon mild electrification(1 V).Bacteria killing stems from membrane stress produced by the PNRs and membrane depolarization caused by electrical neutralization.Additionally,the PNR films exhibit excellent biosafety and electrical stability.The results represent pioneering work in fabricating antibacterial components for FWDs by comprehensively taking into consideration the required conductivity,mechanical properties,and biosafety.
基金This work was supported by City University of Hong Kong Strategic Research Grant(SRG)No.7005264,Guangdong-Hong Kong Technology Cooperation Funding Scheme(TCFS)No.GHP/085/18SZ(CityU 9440230)Hong Kong Research Grants Council General Research Funds(GRF)No.CityU 11205617.
文摘As an important phenomenon to monitor disease development,cell signaling usually takes place at the interface between organisms/cells or between organisms/cells and abiotic materials.Therefore,finding a strategy to build the specific biomedical interfaces will help regulate information transmission and produce better therapeutic results to benefit patients.In the past decades,plasmas containing energetic and active species have been employed to construct various interfaces to meet biomedical demands such as bacteria inactivation,tissue regeneration,cancer therapy,and so on.Based on the potent functions of plasma modified surfaces,this mini-review is aimed to summarize the state-of-art plasma-activated interfaces and provide guidance to researchers to select the proper plasma and processing conditions to design and prepare interfaces with the optimal biological and related functions.After a brief introduction,plasma-activated interfaces are described and categorized according to different criteria including direct plasma-cells interfaces and indirect plasma-material-cells interfaces and recent research activities on the application of plasma-activated interfaces are described.The authors hope that this mini-review will spur interdisciplinary research efforts in this important area and expedite associated clinical applications.
