Electro-optomechanical switch via tunable bistability and four-wave mixing

We investigate the tunable bistable behavior of a hybrid nano-electro-optomechanical system(NEOMS) composed of S-shaped in the presence of two-level atoms, trapped inside a Fabry–Pérot cavity, and driven by a strong driving field and a weak probe field. The bistable behavior of the steady-state photon number and the mechanical steady-state positions are discussed. Further, we tune bistability by tuning all the coupling frequencies involved in the system and amplitude of the driving field. The present study provides the possibility of realization of a controllable optical switch depending on atom-field coupling, optomechanical coupling, electrostatic Coulomb coupling, and threshold power. In addition, we discuss that the non-linear effect of the hybrid NEOMS generates the four-wave mixing(FWM) process. Moreover, we show that the FWM process can be suppressed by the atom-field detuning and cavity-field detuning, which exhibits low photon transmission.

An alternative splicing variant of mineralocorticoid receptor discovered in preeclampsia tissues and its effect on endothelial dysfunction

The pathophysiology of preeclampsia(PE)remains unclear.PE spiral artery remodeling dysfunction and PE offspring cardiovascular future development has been a worldwide concern.We collected placental and umbilical artery samples from normotensive and PE pregnancies.Mineralocorticoid receptor(MR)and its alternative splicing variant(ASV)expression and their biological effects on PE were examined.An MR ASV was found to be highly expressed in all PE samples and slightly expressed in about half of the normotensive samples(umbilical artery,~57.58%;placenta,~36.84%).The MR ASV expression was positively associated with blood pressure in both groups.The MR ASV protein changed the aldosterone-induced expression pattern of MR target genes related to ion exchanges and cell signaling pathways.The MR ASV can also impair the proliferation,migration,and tube formation ability of endothelial cells.These findings indicate that MR ASV in PE placenta plays a pathogenic role in PE pathophysiology,especially in endothelial dysfunction,and the existence of the MR ASV in PE umbilical artery provides a new direction in the study of PE offspring with increased risk of cardiovascular diseases.