The inter-cycle correlation of fission source distributions(FSDs)in the Monte Carlo power iteration process results in variance underestimation of tallied physical quantities,especially in large local tallies.This stu...The inter-cycle correlation of fission source distributions(FSDs)in the Monte Carlo power iteration process results in variance underestimation of tallied physical quantities,especially in large local tallies.This study provides a mesh-free semiquantitative variance underestimation elimination method to obtain a credible confidence interval for the tallied results.This method comprises two procedures:Estimation and Elimination.The FSD inter-cycle correlation length is estimated in the Estimation procedure using the Sliced Wasserstein distance algorithm.The batch method was then used in the elimination procedure.The FSD inter-cycle correlation length was proved to be the optimum batch length to eliminate the variance underestimation problem.We exemplified this method using the OECD sphere array model and 3D PWR BEAVRS model.The results showed that the average variance underestimation ratios of local tallies declined from 37 to 87%to within±5%in these models.展开更多
BACKGROUND Hypereosinophilic syndrome(HES)is classified as primary,secondary or idiopathic.Idiopathic HES(IHES)has a variable clinical presentation and may involve multiple organs causing severe damage.Hepatic sinusoi...BACKGROUND Hypereosinophilic syndrome(HES)is classified as primary,secondary or idiopathic.Idiopathic HES(IHES)has a variable clinical presentation and may involve multiple organs causing severe damage.Hepatic sinusoidal obstruction syndrome(HSOS)is characterized by damage to the endothelial cells of the hepatic sinusoids of the hepatic venules,with occlusion of the hepatic venules,and hepatocyte necrosis.We report a case of IHES with HSOS of uncertain etiology.CASE SUMMARY A 70-year-old male patient was admitted to our hospital with pruritus and a rash on the extremities for>5 mo.He had previously undergone antiallergic treatment and herbal therapy in the local hospital,but the symptoms recurred.Relevant examinations were completed after admission.Bone marrow aspiration biopsy showed a significantly higher percentage of eosinophils(23%)with approximately normal morphology.Ultrasound-guided hepatic aspiration biopsy indicated HSOS.Contrast-enhanced computed tomography(CT)of the upper abdomen showed hepatic venule congestion with hydrothorax and ascites.The patient was initially diagnosed with IHES and hepatic venule occlusion.Prednisone,low molecular weight heparin and ursodeoxycholic acid were given for treatment,followed by discontinuation of low molecular weight heparin due to ecchymosis.Routine blood tests,biochemical tests,and imaging such as enhanced CT of the upper abdomen and pelvis were reviewed regularly.CONCLUSION Hypereosinophilia may play a facilitating role in the occurrence and development of HSOS.展开更多
The use of magnetic nanoparticle(MNP)-labeled immunochromatography test strips(ICTSs) is very important for point-ofcare testing(POCT). However, common diagnostic methods cannot accurately analyze the weak magnetic si...The use of magnetic nanoparticle(MNP)-labeled immunochromatography test strips(ICTSs) is very important for point-ofcare testing(POCT). However, common diagnostic methods cannot accurately analyze the weak magnetic signal from ICTSs, limiting the applications of POCT. In this study, an ultrasensitive multiplex biosensor was designed to overcome the limitations of capturing and normalization of the weak magnetic signal from MNPs on ICTSs. A machine learning model for sandwich assays was constructed and used to classify weakly positive and negative samples, which significantly enhanced the specificity and sensitivity. The potential clinical application was evaluated by detecting 50 human chorionic gonadotropin(HCG) samples and 59 myocardial infarction serum samples. The quantitative range for HCG was 1–1000 mIU mL^(-1) and the ideal detection limit was 0.014 mIU mL^(-1), which was well below the clinical threshold. Quantitative detection results of multiplex cardiac markers showed good linear correlations with standard values. The proposed multiplex assay can be readily adapted for identifying other biomolecules and also be used in other applications such as environmental monitoring, food analysis, and national security.展开更多
A suitable model for high-temperature heat pipe startup is a prerequisite to realizing the numerical simula-tion for the heat pipe cooled reactor startup from the cold state.It is required that this model not only des...A suitable model for high-temperature heat pipe startup is a prerequisite to realizing the numerical simula-tion for the heat pipe cooled reactor startup from the cold state.It is required that this model not only describes the transient behavior during the startup period,but also reduces the computing resources of the heat pipe cooled reactor simulation in the simplest way.In this study,a simplified model that integrates the two-zone and network models is proposed.In this model,vapor flow in the vapor space,evaporation,and condensation in the vapor–liquid interface are decoupled with heat conduction to achieve a fast calculation of the transient characteristics of the heat pipe.An experimental system for a high-temperature heat pipe was developed to validate the proposed model.A potassium heat pipe was utilized as the experimental material.Startup experiments were performed with differ-ent heating powers.Compared with the experimental results,the accuracy of the proposed model was verified.Moreover,the proposed model can predict the vapor flow,pressure drop,and temperature drop in the vapor space.As indicated by the analysis results,the essential requirements for successful startup are also determined.The heat pipe cannot achieve a successful startup until the heating power satisfies these requirements.All the discussions indicate the capability of the proposed model for the simulation of a high-temperature heat pipe startup from the frozen state;hence,can act as a basic tool for the heat pipe cooled reactor simulation.展开更多
In loosely coupled or large-scale problems with high dominance ratios,slow fission source convergence can take extremely long time,reducing Monte Carlo(MC)criticality calculation efficiency.Although various accelerati...In loosely coupled or large-scale problems with high dominance ratios,slow fission source convergence can take extremely long time,reducing Monte Carlo(MC)criticality calculation efficiency.Although various acceleration methods have been developed,some methods cannot reduce convergence times,whereas others have been limited to specific problem geometries.In this study,a new fission source convergence acceleration(FSCA)method,the forced propagation(FP)method,has been proposed,which forces the fission source to propagate and accelerate fission source convergence.Additionally,some stabilization techniques have been designed to render the method more practical.The resulting stabilized method was then successfully implemented in the MC transport code,and its feasibility and effectiveness were tested using the modified OECD/NEA,one-dimensional slab benchmark,and the Hoogenboom full-core problem.The comparison results showed that the FP method was able to achieve efficient FSCA.展开更多
The transport cross-section based on inflow transport approximation can significantly improve the accuracy of light water reactor(LWR)analysis,especially for the treatment of the anisotropic scattering effect.The prev...The transport cross-section based on inflow transport approximation can significantly improve the accuracy of light water reactor(LWR)analysis,especially for the treatment of the anisotropic scattering effect.The previous inflow transport approximation is based on the moderator cross-section and normalized fission source,which is approximated using transport theory.Although the accuracy of reactivity is increased,the P0 flux moment has a large error in the Monte Carlo code.In this study,an improved inflow transport approximation was introduced with homogenization techniques,applying the homogenized cross-section and accurate fission source.The numerical results indicated that the improved inflow transport approximation can increase the P0 flux moment accuracy and maintain the reactivity calculation precision with the previous inflow transport approximation in typical LWR cases.In addition to this investigation,the improved inflow transport approximation is related to the temperature factors.The improved inflow transport approximation is flexible and accurate in the treatment of the anisotropic scattering effect,which can be directly used in the temperature-dependent nuclear data library.展开更多
On-the-fly Doppler broadening of cross sections is important in Monte Carlo simulations,particularly in Monte Carlo neutronics-thermal hydraulics coupling simulations.Methods such as Target Motion Sampling(TMS)and win...On-the-fly Doppler broadening of cross sections is important in Monte Carlo simulations,particularly in Monte Carlo neutronics-thermal hydraulics coupling simulations.Methods such as Target Motion Sampling(TMS)and windowed multipole as well as a method based on regression models have been developed to solve this problem.However,these methods have limitations such as the need for a cross section in an ACE format at a given temperature or a limited application energy range.In this study,a new on-the-fly Doppler broadening method based on a Back Propagation(BP)neural network,called hybrid windowed networks(HWN),is proposed to resolve the resonance energy range.In the HWN method,the resolved resonance energy range is divided into windows to guarantee an even distribution of resonance peaks.BP networks with specially designed structures and training parameters are trained to evaluate the cross section at a base temperature and the broadening coefficient.The HWN method is implemented in the Reactor Monte Carlo(RMC)code,and the microscopic cross sections and macroscopic results are compared.The results show that the HWN method can reduce the memory requirement for cross-sectional data by approximately 65%;moreover,it can generate keff,power distribution,and energy spectrum results with acceptable accuracy and a limited increase in the calculation time.The feasibility and effectiveness of the proposed HWN method are thus demonstrated.展开更多
Objective: Human induced pluripotent stem(i PS) cells exhibit great potential for generating functional human cells for medical therapies. In this paper, we report for use of human i PS cells labeled with fluorescent ...Objective: Human induced pluripotent stem(i PS) cells exhibit great potential for generating functional human cells for medical therapies. In this paper, we report for use of human i PS cells labeled with fluorescent magnetic nanoparticles(FMNPs) for targeted imaging and synergistic therapy of gastric cancer cells in vivo. Methods: Human i PS cells were prepared and cultured for 72 h. The culture medium was collected, and then was coincubated with MGC803 cells. Cell viability was analyzed by the MTT method. FMNP-labeled human i PS cells were prepared and injected into gastric cancer-bearing nude mice. The mouse model was observed using a small-animal imaging system. The nude mice were irradiated under an external alternating magnetic field and evaluated using an infrared thermal mapping instrument. Tumor sizes were measured weekly. Results: iP S cells and the collected culture medium inhibited the growth of MGC803 cells. FMNP-labeled human iP S cells targeted and imaged gastric cancer cells in vivo, as well as inhibited cancer growth in vivo through the external magnetic field. Conclusion: FMNP-labeled human i PS cells exhibit considerable potential in applications such as targeted dual-mode imaging and synergistic therapy for early gastric cancer.展开更多
This paper studies several performance metrics of a wireless-powered decode-and-forward(DF) relay network with imperfect channel state information(CSI). In particular, based on the time switching(TS) protocol, the ene...This paper studies several performance metrics of a wireless-powered decode-and-forward(DF) relay network with imperfect channel state information(CSI). In particular, based on the time switching(TS) protocol, the energy-constrained relay harvesting energy from a power beacon(PB), and uses that harvested energy to forward the source information to destination. The closedform expression of the outage probability is firstly derived over Rayleigh fading channels. Then, the asymptotic analysis, throughput as well as the symbol error probability(SEP) are derived based on the expression of the outage probability. Next, both transmission power of the source and the power beacon are optimized through the throughput optimization. Finally, simulations are conducted to corroborate our theoretical analysis, and to reveal the impact of the transmission power of the source and PB as well as the imperfect CSI on the system performance.展开更多
A global variance reduction(GVR)method based on the SPN method is proposed.First,the global multi-group cross-sections are obtained by Monte Carlo(MC)global homogenization.Then,the SP3 equation is solved to obtain the...A global variance reduction(GVR)method based on the SPN method is proposed.First,the global multi-group cross-sections are obtained by Monte Carlo(MC)global homogenization.Then,the SP3 equation is solved to obtain the global flux distribution.Finally,the global weight windows are approximated by the global flux distribution,and the GVR simulation is performed.This GVR method is implemented as an automatic process in the RMC code.The SP3-coupled GVR method was tested on a modified version of C5 G7 benchmark with a thickened water shield.The results show that the SP3-coupled GVR method can improve the efficiency of MC criticality calculation.展开更多
基金supported by China Nuclear Power Engineering Co.,Ltd.Scientific Research Project(No.KY22104)the fellowship of China Postdoctoral Science Foundation(No.2022M721793).
文摘The inter-cycle correlation of fission source distributions(FSDs)in the Monte Carlo power iteration process results in variance underestimation of tallied physical quantities,especially in large local tallies.This study provides a mesh-free semiquantitative variance underestimation elimination method to obtain a credible confidence interval for the tallied results.This method comprises two procedures:Estimation and Elimination.The FSD inter-cycle correlation length is estimated in the Estimation procedure using the Sliced Wasserstein distance algorithm.The batch method was then used in the elimination procedure.The FSD inter-cycle correlation length was proved to be the optimum batch length to eliminate the variance underestimation problem.We exemplified this method using the OECD sphere array model and 3D PWR BEAVRS model.The results showed that the average variance underestimation ratios of local tallies declined from 37 to 87%to within±5%in these models.
基金the National Science of Foundation Committee of Zhejiang Province,No.LY22H160003the Zhejiang Provincial Medical and Health Science Foundation,No.2021441200 and No.2021RC083.
文摘BACKGROUND Hypereosinophilic syndrome(HES)is classified as primary,secondary or idiopathic.Idiopathic HES(IHES)has a variable clinical presentation and may involve multiple organs causing severe damage.Hepatic sinusoidal obstruction syndrome(HSOS)is characterized by damage to the endothelial cells of the hepatic sinusoids of the hepatic venules,with occlusion of the hepatic venules,and hepatocyte necrosis.We report a case of IHES with HSOS of uncertain etiology.CASE SUMMARY A 70-year-old male patient was admitted to our hospital with pruritus and a rash on the extremities for>5 mo.He had previously undergone antiallergic treatment and herbal therapy in the local hospital,but the symptoms recurred.Relevant examinations were completed after admission.Bone marrow aspiration biopsy showed a significantly higher percentage of eosinophils(23%)with approximately normal morphology.Ultrasound-guided hepatic aspiration biopsy indicated HSOS.Contrast-enhanced computed tomography(CT)of the upper abdomen showed hepatic venule congestion with hydrothorax and ascites.The patient was initially diagnosed with IHES and hepatic venule occlusion.Prednisone,low molecular weight heparin and ursodeoxycholic acid were given for treatment,followed by discontinuation of low molecular weight heparin due to ecchymosis.Routine blood tests,biochemical tests,and imaging such as enhanced CT of the upper abdomen and pelvis were reviewed regularly.CONCLUSION Hypereosinophilia may play a facilitating role in the occurrence and development of HSOS.
基金support by the National Key Research and Development Program of China (Grant Nos. 2017FYA0205301, and 2017FYA0205303)the National Natural Science Foundation of China (Grant Nos. 81571835 and 81672247)+3 种基金National Key Research and Development Program of China (No. 2017YFA0205303)National Key Basic Research Program (973 Project) (No. 2015CB931802)"13th Five-Year Plan" Science and Technology Project of Jilin Province Education Department (No. JJKH20170410K)Shanghai Science and Technology Fund (No. 15DZ2252000)
文摘The use of magnetic nanoparticle(MNP)-labeled immunochromatography test strips(ICTSs) is very important for point-ofcare testing(POCT). However, common diagnostic methods cannot accurately analyze the weak magnetic signal from ICTSs, limiting the applications of POCT. In this study, an ultrasensitive multiplex biosensor was designed to overcome the limitations of capturing and normalization of the weak magnetic signal from MNPs on ICTSs. A machine learning model for sandwich assays was constructed and used to classify weakly positive and negative samples, which significantly enhanced the specificity and sensitivity. The potential clinical application was evaluated by detecting 50 human chorionic gonadotropin(HCG) samples and 59 myocardial infarction serum samples. The quantitative range for HCG was 1–1000 mIU mL^(-1) and the ideal detection limit was 0.014 mIU mL^(-1), which was well below the clinical threshold. Quantitative detection results of multiplex cardiac markers showed good linear correlations with standard values. The proposed multiplex assay can be readily adapted for identifying other biomolecules and also be used in other applications such as environmental monitoring, food analysis, and national security.
基金This work was supported by the National Key Research and Development Project of China(No.2020YFB1901700)Science Challenge Project(No.TZ2018001)+1 种基金the National Natural Science Foundation of China(Nos.11775126 and 11775127)the Tsinghua University Initiative Scientific Research Program.
文摘A suitable model for high-temperature heat pipe startup is a prerequisite to realizing the numerical simula-tion for the heat pipe cooled reactor startup from the cold state.It is required that this model not only describes the transient behavior during the startup period,but also reduces the computing resources of the heat pipe cooled reactor simulation in the simplest way.In this study,a simplified model that integrates the two-zone and network models is proposed.In this model,vapor flow in the vapor space,evaporation,and condensation in the vapor–liquid interface are decoupled with heat conduction to achieve a fast calculation of the transient characteristics of the heat pipe.An experimental system for a high-temperature heat pipe was developed to validate the proposed model.A potassium heat pipe was utilized as the experimental material.Startup experiments were performed with differ-ent heating powers.Compared with the experimental results,the accuracy of the proposed model was verified.Moreover,the proposed model can predict the vapor flow,pressure drop,and temperature drop in the vapor space.As indicated by the analysis results,the essential requirements for successful startup are also determined.The heat pipe cannot achieve a successful startup until the heating power satisfies these requirements.All the discussions indicate the capability of the proposed model for the simulation of a high-temperature heat pipe startup from the frozen state;hence,can act as a basic tool for the heat pipe cooled reactor simulation.
基金supported by the National Natural Science Foundation of China(Nos.11775126,11545013,11605101)the Young Elite Scientists Sponsorship Program by CAST(No.2016QNRC001)+1 种基金Science Challenge Project by MIIT of China(No.TZ2018001)Tsinghua University,Initiative Scientific Research Program。
文摘In loosely coupled or large-scale problems with high dominance ratios,slow fission source convergence can take extremely long time,reducing Monte Carlo(MC)criticality calculation efficiency.Although various acceleration methods have been developed,some methods cannot reduce convergence times,whereas others have been limited to specific problem geometries.In this study,a new fission source convergence acceleration(FSCA)method,the forced propagation(FP)method,has been proposed,which forces the fission source to propagate and accelerate fission source convergence.Additionally,some stabilization techniques have been designed to render the method more practical.The resulting stabilized method was then successfully implemented in the MC transport code,and its feasibility and effectiveness were tested using the modified OECD/NEA,one-dimensional slab benchmark,and the Hoogenboom full-core problem.The comparison results showed that the FP method was able to achieve efficient FSCA.
基金supported by the National Key R&D Program of China(No.2017YFC0307800-05).
文摘The transport cross-section based on inflow transport approximation can significantly improve the accuracy of light water reactor(LWR)analysis,especially for the treatment of the anisotropic scattering effect.The previous inflow transport approximation is based on the moderator cross-section and normalized fission source,which is approximated using transport theory.Although the accuracy of reactivity is increased,the P0 flux moment has a large error in the Monte Carlo code.In this study,an improved inflow transport approximation was introduced with homogenization techniques,applying the homogenized cross-section and accurate fission source.The numerical results indicated that the improved inflow transport approximation can increase the P0 flux moment accuracy and maintain the reactivity calculation precision with the previous inflow transport approximation in typical LWR cases.In addition to this investigation,the improved inflow transport approximation is related to the temperature factors.The improved inflow transport approximation is flexible and accurate in the treatment of the anisotropic scattering effect,which can be directly used in the temperature-dependent nuclear data library.
基金supported by the Science Challenge Project(No.TZ2018001)the National Natural Science Foundation of China(Nos.11775126,11545013,11775127)+1 种基金Young Elite Scientists Sponsorship Program by CAST(No.2016QNRC001)Tsinghua University Initiative Scientific Research Program。
文摘On-the-fly Doppler broadening of cross sections is important in Monte Carlo simulations,particularly in Monte Carlo neutronics-thermal hydraulics coupling simulations.Methods such as Target Motion Sampling(TMS)and windowed multipole as well as a method based on regression models have been developed to solve this problem.However,these methods have limitations such as the need for a cross section in an ACE format at a given temperature or a limited application energy range.In this study,a new on-the-fly Doppler broadening method based on a Back Propagation(BP)neural network,called hybrid windowed networks(HWN),is proposed to resolve the resonance energy range.In the HWN method,the resolved resonance energy range is divided into windows to guarantee an even distribution of resonance peaks.BP networks with specially designed structures and training parameters are trained to evaluate the cross section at a base temperature and the broadening coefficient.The HWN method is implemented in the Reactor Monte Carlo(RMC)code,and the microscopic cross sections and macroscopic results are compared.The results show that the HWN method can reduce the memory requirement for cross-sectional data by approximately 65%;moreover,it can generate keff,power distribution,and energy spectrum results with acceptable accuracy and a limited increase in the calculation time.The feasibility and effectiveness of the proposed HWN method are thus demonstrated.
基金supported by National Natural Science Foundation of China (Grant No. 81225010, 20803040, 81028009, and 31170961)National Key Basic Research Program of China (973 Program) (Grant No. 2010CB933902 and 2015CB931802)+1 种基金National Key Technology Research and Development Program (863 Program) (Grant No. 2012AA022703 and 2014AA020700)Shanghai Science and Technology Fund (Grant No.13NM1401500)
文摘Objective: Human induced pluripotent stem(i PS) cells exhibit great potential for generating functional human cells for medical therapies. In this paper, we report for use of human i PS cells labeled with fluorescent magnetic nanoparticles(FMNPs) for targeted imaging and synergistic therapy of gastric cancer cells in vivo. Methods: Human i PS cells were prepared and cultured for 72 h. The culture medium was collected, and then was coincubated with MGC803 cells. Cell viability was analyzed by the MTT method. FMNP-labeled human i PS cells were prepared and injected into gastric cancer-bearing nude mice. The mouse model was observed using a small-animal imaging system. The nude mice were irradiated under an external alternating magnetic field and evaluated using an infrared thermal mapping instrument. Tumor sizes were measured weekly. Results: iP S cells and the collected culture medium inhibited the growth of MGC803 cells. FMNP-labeled human iP S cells targeted and imaged gastric cancer cells in vivo, as well as inhibited cancer growth in vivo through the external magnetic field. Conclusion: FMNP-labeled human i PS cells exhibit considerable potential in applications such as targeted dual-mode imaging and synergistic therapy for early gastric cancer.
基金support by the National Natural Science Foundation of China (nos. 61571340, 61301170)the Fundamental Research Funds for the Central Universities of China under Grant JB150109the 111 Project under Grant B08038
文摘This paper studies several performance metrics of a wireless-powered decode-and-forward(DF) relay network with imperfect channel state information(CSI). In particular, based on the time switching(TS) protocol, the energy-constrained relay harvesting energy from a power beacon(PB), and uses that harvested energy to forward the source information to destination. The closedform expression of the outage probability is firstly derived over Rayleigh fading channels. Then, the asymptotic analysis, throughput as well as the symbol error probability(SEP) are derived based on the expression of the outage probability. Next, both transmission power of the source and the power beacon are optimized through the throughput optimization. Finally, simulations are conducted to corroborate our theoretical analysis, and to reveal the impact of the transmission power of the source and PB as well as the imperfect CSI on the system performance.
基金Supported by the Shanghai Sailing Program,China(No.21YF1421100)the Startup Fund for Youngman Research at SJTU。
文摘A global variance reduction(GVR)method based on the SPN method is proposed.First,the global multi-group cross-sections are obtained by Monte Carlo(MC)global homogenization.Then,the SP3 equation is solved to obtain the global flux distribution.Finally,the global weight windows are approximated by the global flux distribution,and the GVR simulation is performed.This GVR method is implemented as an automatic process in the RMC code.The SP3-coupled GVR method was tested on a modified version of C5 G7 benchmark with a thickened water shield.The results show that the SP3-coupled GVR method can improve the efficiency of MC criticality calculation.
