Objective: To compare the effect of neoadjuvant chemotherapy (NACT) with adjuvant chemotherapy (ACT) using oxaliplatin plus S-1 (sex) or capecitabine (CapeOX) on gastric cancer patients with D2 lymphadenectom...Objective: To compare the effect of neoadjuvant chemotherapy (NACT) with adjuvant chemotherapy (ACT) using oxaliplatin plus S-1 (sex) or capecitabine (CapeOX) on gastric cancer patients with D2 lymphadenectomy. Methods: This was a two-by-two factorial randomized phase Ⅱ-Ⅲ trial, and registered on ISRCTN registry (No. ISRCTN12206108). Locally advanced gastric cancer patients were randomized to neoadjuvant sex, neoadjuvant CapeOX, adjuvant sex, or adjuvant CapeOX arms. Primary analysis was performed on an intention- to-treat (ITT) basis using overall survival (OS) as primary endpoint. Results: This trial started in September 2011 and closed in December 2012 with 100 patients enrolled. Treatment completion rate was 56%, 52%, 38% and 30% in the four arms, respectively. NACT group had fewer dropouts due to unacceptable toxicity (P=0.042). Surgical complication rate did not differ by the four groups (P=0.986). No survival signifcant difference was found comparing NACT with ACT (P=0.664; 5-year-OS: 70% vs. 74% respectively), nor between the sex and CapeOX groups (P=0.252; 5-year-OS: 78% vs. 66% respectively). Subgroup analysis showed sex significantly improved survival in patents with diffuse type (P=0.048). Conclusions: No significant survival difference was found between NACT and ACT. sex and CapeOX had good safety and efficacy as neoadjuvant regimens. Diffuse type patients may survive longer due to sex.展开更多
Objective:This study aims to verify the feasibility and efficacy of laparoscopic lower mediastinal lymphadenectomy for Siewert typeⅡ/Ⅲadenocarcinoma of esophagogastric junction(AEG).Setting:An exploratory,observatio...Objective:This study aims to verify the feasibility and efficacy of laparoscopic lower mediastinal lymphadenectomy for Siewert typeⅡ/Ⅲadenocarcinoma of esophagogastric junction(AEG).Setting:An exploratory,observational,prospective,cohort study will be carried out under the Idea,Development,Exploration,Assessment and Long-term Follow-up(IDEAL)framework(stage 2 b).Paritcipants:The study will recruit 1,036 patients with cases of locally advanced AEG(Siewert typeⅡ/Ⅲ,clinical stage cT2-4 aN0-3 M0),and 518 will be assigned to either the laparoscopy group or the open group.Interventions:Patients will receive lower mediastinal lymphadenectomy along with either total or proximal gastrectomy.Primary and secondary outcome measures:The primary endpoint is the number of lower mediastinal lymph nodes retrieved,and the secondary endpoints are the surgical safety and prognosis,including intraoperative and postoperative lower-mediastinal-lymphadenectomy-related morbidity and mortality,rate of rehospitalization,R0 resection rate,3-year local recurrence rate,and 3-year overall survival.Conclusions:The study will provide data for the guidance and development of surgical treatment strategies for AEG.Trial registration number:The study has been registered in ClinicalTrials.gov(No.NCT04443478).展开更多
Since the first outbreak of the coronavirus disease(COVID-19)in the winter of 2019,this pandemic has resulted in significant global social and economic disruption,as well as global public health and medical crises[1]....Since the first outbreak of the coronavirus disease(COVID-19)in the winter of 2019,this pandemic has resulted in significant global social and economic disruption,as well as global public health and medical crises[1].Climate,weather conditions,and even latitude have now been acknowledged to be directly associated with COVID-19 outbreaks[2-4].It was reported that 60%of the confirmed cases of COVID-19 occurred in areas where the air temperature ranged from 5℃to 15℃[4].These earlier research results strongly implied that the COVID-19 pandemic might spread cyclically and outbreaks might recur in large cities in the mid-latitudes(for example,the northern part of China)in autumn 2020[4],which has now been confirmed by the third wave of the pandemic.With quarantines and other restrictive legislations and control measures being put in action to contain the spread of the disease[5],the pandemic has also manifested additional obstacles in the treatment of other diseases.For example,a median dose delay of 14(6-20)days was found in patients who received one cycle of gastric chemotherapy in our department from the first outbreak till the spring festival of 2020(n=79).展开更多
Despite surgical improvements and pharmacological advances,management of late-stage gastric cancer patients,especially those with hepatic metastasis remains challenging[1–3].Although nationwide registry data from SEE...Despite surgical improvements and pharmacological advances,management of late-stage gastric cancer patients,especially those with hepatic metastasis remains challenging[1–3].Although nationwide registry data from SEER(Surveillance,Epidemiology,and End Results)[4]and the Nordic database[5]in Western countries have provided epidemiological information for patients with gastric cancer liver metastasis(GCLM),little is known about the detailed clinical characteristics.展开更多
基金supported in part by the grants from Beijing Municipal Science&Technology Commission(No D171100006517002)
文摘Objective: To compare the effect of neoadjuvant chemotherapy (NACT) with adjuvant chemotherapy (ACT) using oxaliplatin plus S-1 (sex) or capecitabine (CapeOX) on gastric cancer patients with D2 lymphadenectomy. Methods: This was a two-by-two factorial randomized phase Ⅱ-Ⅲ trial, and registered on ISRCTN registry (No. ISRCTN12206108). Locally advanced gastric cancer patients were randomized to neoadjuvant sex, neoadjuvant CapeOX, adjuvant sex, or adjuvant CapeOX arms. Primary analysis was performed on an intention- to-treat (ITT) basis using overall survival (OS) as primary endpoint. Results: This trial started in September 2011 and closed in December 2012 with 100 patients enrolled. Treatment completion rate was 56%, 52%, 38% and 30% in the four arms, respectively. NACT group had fewer dropouts due to unacceptable toxicity (P=0.042). Surgical complication rate did not differ by the four groups (P=0.986). No survival signifcant difference was found comparing NACT with ACT (P=0.664; 5-year-OS: 70% vs. 74% respectively), nor between the sex and CapeOX groups (P=0.252; 5-year-OS: 78% vs. 66% respectively). Subgroup analysis showed sex significantly improved survival in patents with diffuse type (P=0.048). Conclusions: No significant survival difference was found between NACT and ACT. sex and CapeOX had good safety and efficacy as neoadjuvant regimens. Diffuse type patients may survive longer due to sex.
基金supported by the Chinese Medical Foundation(No.2020064)。
文摘Objective:This study aims to verify the feasibility and efficacy of laparoscopic lower mediastinal lymphadenectomy for Siewert typeⅡ/Ⅲadenocarcinoma of esophagogastric junction(AEG).Setting:An exploratory,observational,prospective,cohort study will be carried out under the Idea,Development,Exploration,Assessment and Long-term Follow-up(IDEAL)framework(stage 2 b).Paritcipants:The study will recruit 1,036 patients with cases of locally advanced AEG(Siewert typeⅡ/Ⅲ,clinical stage cT2-4 aN0-3 M0),and 518 will be assigned to either the laparoscopy group or the open group.Interventions:Patients will receive lower mediastinal lymphadenectomy along with either total or proximal gastrectomy.Primary and secondary outcome measures:The primary endpoint is the number of lower mediastinal lymph nodes retrieved,and the secondary endpoints are the surgical safety and prognosis,including intraoperative and postoperative lower-mediastinal-lymphadenectomy-related morbidity and mortality,rate of rehospitalization,R0 resection rate,3-year local recurrence rate,and 3-year overall survival.Conclusions:The study will provide data for the guidance and development of surgical treatment strategies for AEG.Trial registration number:The study has been registered in ClinicalTrials.gov(No.NCT04443478).
基金supported by the Summit Talent Plan(to JJ,No.DFL20181103)Young Scholar Program of Beijing Hospitals Authority(to ZW,No.QMS20191103).
文摘Since the first outbreak of the coronavirus disease(COVID-19)in the winter of 2019,this pandemic has resulted in significant global social and economic disruption,as well as global public health and medical crises[1].Climate,weather conditions,and even latitude have now been acknowledged to be directly associated with COVID-19 outbreaks[2-4].It was reported that 60%of the confirmed cases of COVID-19 occurred in areas where the air temperature ranged from 5℃to 15℃[4].These earlier research results strongly implied that the COVID-19 pandemic might spread cyclically and outbreaks might recur in large cities in the mid-latitudes(for example,the northern part of China)in autumn 2020[4],which has now been confirmed by the third wave of the pandemic.With quarantines and other restrictive legislations and control measures being put in action to contain the spread of the disease[5],the pandemic has also manifested additional obstacles in the treatment of other diseases.For example,a median dose delay of 14(6-20)days was found in patients who received one cycle of gastric chemotherapy in our department from the first outbreak till the spring festival of 2020(n=79).
基金This work was supported by the National Natural Science Foundation of China(81972790)the Beijing Nova Program(Z181100006218011).
文摘Despite surgical improvements and pharmacological advances,management of late-stage gastric cancer patients,especially those with hepatic metastasis remains challenging[1–3].Although nationwide registry data from SEER(Surveillance,Epidemiology,and End Results)[4]and the Nordic database[5]in Western countries have provided epidemiological information for patients with gastric cancer liver metastasis(GCLM),little is known about the detailed clinical characteristics.