OBJECTIVES: This study sought to investigate the regional frequency distributi on from multiple bi-atrial sites in different types of paroxysmal atrial fibril lation(AF). BACKGROUND: A previous study showed a left atr...OBJECTIVES: This study sought to investigate the regional frequency distributi on from multiple bi-atrial sites in different types of paroxysmal atrial fibril lation(AF). BACKGROUND: A previous study showed a left atrium(LA) to right atriu m(RA) frequency gradient in patients with paroxysmal AF. METHODS: Forty-four pa tients(age=60±16, male patients=27) with paroxysmal AF originating from the pul monary veins(PVs)(n=31) or superior vena cava(SVC)(n=13) were included. Frequenc y analysis was performed on the intracardiac electrograms(7 s, 1 kHz/channel) re corded from PV, posterior LA, coronary sinus(CS), posterolateral RA, and SVC. Th e largest peak frequency was identified as the dominant frequency(DF). RESULTS: In the PV-AF patients, there was a frequency gradient from the PV ostium to the LA, RA, and SVC(8.5±3.3 Hz vs. 5.9±1.1 Hz vs. 5.2±0.85 Hz vs. 5.5±0.48 Hz, respectively, p< 0.001). The highest DFs were mostly located at the arrhythmogen ic PV ostium(58%). The DFs of the arrhythmogenic PV and PV ostium were signific antly higher than those of the non-arrhythmogenic PVs and PV ostia(p< 0.05). In the SVC-AF patients, there was a frequency gradient from the SVC to the RA, LA , and PV(8.0±2.4 Hz vs. 5.9±1.1 Hz vs. 5.9±0.7 Hz vs. 5.8±0.7 Hz, respective ly, p=0.001). The highest DFs were mostly located inside the SVC(77%) instead o f the SVC ostium(as compared with PV-AF patients, p=0.035). CONCLUSIONS: The lo cation of the highest DF depended on the arrhythmogenic PV or SVC. A frequency g radient was present between the arrhythmogenic thoracic vein and atrium in all p atients.展开更多
文摘OBJECTIVES: This study sought to investigate the regional frequency distributi on from multiple bi-atrial sites in different types of paroxysmal atrial fibril lation(AF). BACKGROUND: A previous study showed a left atrium(LA) to right atriu m(RA) frequency gradient in patients with paroxysmal AF. METHODS: Forty-four pa tients(age=60±16, male patients=27) with paroxysmal AF originating from the pul monary veins(PVs)(n=31) or superior vena cava(SVC)(n=13) were included. Frequenc y analysis was performed on the intracardiac electrograms(7 s, 1 kHz/channel) re corded from PV, posterior LA, coronary sinus(CS), posterolateral RA, and SVC. Th e largest peak frequency was identified as the dominant frequency(DF). RESULTS: In the PV-AF patients, there was a frequency gradient from the PV ostium to the LA, RA, and SVC(8.5±3.3 Hz vs. 5.9±1.1 Hz vs. 5.2±0.85 Hz vs. 5.5±0.48 Hz, respectively, p< 0.001). The highest DFs were mostly located at the arrhythmogen ic PV ostium(58%). The DFs of the arrhythmogenic PV and PV ostium were signific antly higher than those of the non-arrhythmogenic PVs and PV ostia(p< 0.05). In the SVC-AF patients, there was a frequency gradient from the SVC to the RA, LA , and PV(8.0±2.4 Hz vs. 5.9±1.1 Hz vs. 5.9±0.7 Hz vs. 5.8±0.7 Hz, respective ly, p=0.001). The highest DFs were mostly located inside the SVC(77%) instead o f the SVC ostium(as compared with PV-AF patients, p=0.035). CONCLUSIONS: The lo cation of the highest DF depended on the arrhythmogenic PV or SVC. A frequency g radient was present between the arrhythmogenic thoracic vein and atrium in all p atients.
