AIM:To estimate the prevalence of the lactase non-persistent genotype(C/C-13910)in a northern Russian population in accordance with ethnicity,and to evaluate self-reported milk consumption depending on lactase activit...AIM:To estimate the prevalence of the lactase non-persistent genotype(C/C-13910)in a northern Russian population in accordance with ethnicity,and to evaluate self-reported milk consumption depending on lactase activity. METHODS:Blood samples for genotyping lactase activity,defining the C/T-13910 variant by polymerase chain reaction,and direct sequencing were taken from 231 medical students of Russian origin aged 17-26 years. We analyzed milk product consumption by questionnaire which was specially designed for the estimation of milk consumption and abdominal complaints. RESULTS:We found that the prevalence of the C/C-13190 genotype in the northern Russian population was 35.6%.The other genotypes nearby C/T-13910 and associated with lactase activity were not present in the study population.The consumption of milk among people with the non-persistent genotype tended to be lower than among the lactose tolerant subjects,but was not statistically significant.CONCLUSION:An investigation of the lactase persistent genotype in a northern Russian population has not been performed before.The genotype did not affect the consumption of milk products in this population which could be explained by low consumption of milk products among the entire study population.展开更多
Background: It has been suggested that childhood events increase the risk of suffering from an eating disorder (ED) in adolescence or young adulthood. Our study here aimed at investigating whether there was an associa...Background: It has been suggested that childhood events increase the risk of suffering from an eating disorder (ED) in adolescence or young adulthood. Our study here aimed at investigating whether there was an association between stressful childhood events and eating disorders later in life. Methods: Our population-based study was a part of the HeSSup (The Health and Social Support) postal survey in 2003, a follow-up survey with a random sample of working-aged subjects drawn from the Finnish Population Register in 1998. Participants in this study reported having been suffering from ED (N = 374), while controls (N = 18,639) reported no history of eating disorder in the questionnaire both in 1998 and 2003. The questionnaire included six questions related to childhood adversities. Results: Each childhood stressor increased the risk of developing ED cumulatively (one adversity OR 1.7 versus all six OR 8.3). Intrafamiliar conflicts (OR 2.0), being afraid of a family member (OR 1.5) or long-term illnesses in the family (OR 1.4) increased the ED-risk statistical significantly. Conclusion: Children exposed to stress are more likely to suffer from eating disorders as adults than those not exposed.展开更多
基金The Sigrid Jusélius Foundation,Helsinki,Finland and Tampere University Hospital Research Funds
文摘AIM:To estimate the prevalence of the lactase non-persistent genotype(C/C-13910)in a northern Russian population in accordance with ethnicity,and to evaluate self-reported milk consumption depending on lactase activity. METHODS:Blood samples for genotyping lactase activity,defining the C/T-13910 variant by polymerase chain reaction,and direct sequencing were taken from 231 medical students of Russian origin aged 17-26 years. We analyzed milk product consumption by questionnaire which was specially designed for the estimation of milk consumption and abdominal complaints. RESULTS:We found that the prevalence of the C/C-13190 genotype in the northern Russian population was 35.6%.The other genotypes nearby C/T-13910 and associated with lactase activity were not present in the study population.The consumption of milk among people with the non-persistent genotype tended to be lower than among the lactose tolerant subjects,but was not statistically significant.CONCLUSION:An investigation of the lactase persistent genotype in a northern Russian population has not been performed before.The genotype did not affect the consumption of milk products in this population which could be explained by low consumption of milk products among the entire study population.
基金Centre for General Practice,Pirkanmaa Hospital District has supported the work financially.
文摘Background: It has been suggested that childhood events increase the risk of suffering from an eating disorder (ED) in adolescence or young adulthood. Our study here aimed at investigating whether there was an association between stressful childhood events and eating disorders later in life. Methods: Our population-based study was a part of the HeSSup (The Health and Social Support) postal survey in 2003, a follow-up survey with a random sample of working-aged subjects drawn from the Finnish Population Register in 1998. Participants in this study reported having been suffering from ED (N = 374), while controls (N = 18,639) reported no history of eating disorder in the questionnaire both in 1998 and 2003. The questionnaire included six questions related to childhood adversities. Results: Each childhood stressor increased the risk of developing ED cumulatively (one adversity OR 1.7 versus all six OR 8.3). Intrafamiliar conflicts (OR 2.0), being afraid of a family member (OR 1.5) or long-term illnesses in the family (OR 1.4) increased the ED-risk statistical significantly. Conclusion: Children exposed to stress are more likely to suffer from eating disorders as adults than those not exposed.
