DNA topoisomerases carry out their reactions by generating transient covalent phosphotyrosine intermediates with DNA [ 1 ]. This reaction mechanism allows these enzymes that need to break DNA to do so in a way that do...DNA topoisomerases carry out their reactions by generating transient covalent phosphotyrosine intermediates with DNA [ 1 ]. This reaction mechanism allows these enzymes that need to break DNA to do so in a way that does not induce genome rearrangements or DNA damage responses. However, a variety of agents are able to trap topoisomerases while they are covalently bound to DNA.展开更多
文摘DNA topoisomerases carry out their reactions by generating transient covalent phosphotyrosine intermediates with DNA [ 1 ]. This reaction mechanism allows these enzymes that need to break DNA to do so in a way that does not induce genome rearrangements or DNA damage responses. However, a variety of agents are able to trap topoisomerases while they are covalently bound to DNA.
