The continuation of the spermatogenic process through-out life relies on a proper regulation of self-renewal and differentiation ofgermline testis stem cells, the spermatogonial stem cells. These are single cells situ...The continuation of the spermatogenic process through-out life relies on a proper regulation of self-renewal and differentiation ofgermline testis stem cells, the spermatogonial stem cells. These are single cells situated on the basal membrane of the seminiferous epithelium. Only 0.03% of all germ cells are spermatogonial stem cells （SSCs） [1-3]. To maintain spermatogenesis, the processes of self-renewal and differentiation of S SCs must be precisely regulated by intrinsic gene expression in the stem cells and extrinsic signals, including soluble factors or adhesion molecules from the surrounding microenvironment, the stem cell niche.展开更多
文摘The continuation of the spermatogenic process through-out life relies on a proper regulation of self-renewal and differentiation ofgermline testis stem cells, the spermatogonial stem cells. These are single cells situated on the basal membrane of the seminiferous epithelium. Only 0.03% of all germ cells are spermatogonial stem cells （SSCs） [1-3]. To maintain spermatogenesis, the processes of self-renewal and differentiation of S SCs must be precisely regulated by intrinsic gene expression in the stem cells and extrinsic signals, including soluble factors or adhesion molecules from the surrounding microenvironment, the stem cell niche.
