Endogenous cytoplasmic DNA(cytoDNA)species are emerging as key mediators of inflammation in diverse physiological and pathological contexts.Although the role of endogenous cytoDNA in innate immune activation is well e...Endogenous cytoplasmic DNA(cytoDNA)species are emerging as key mediators of inflammation in diverse physiological and pathological contexts.Although the role of endogenous cytoDNA in innate immune activation is well established,the cytoDNA species themselves are often poorly characterized and difficult to distinguish,and their mechanisms of formation,scope of function and contribution to disease are incompletely understood.展开更多
Endogenous cytoplasmic DNA(cytoDNA)species are emerging as key mediators of inflammation in diverse physiological and pathological contexts.Although the role of endogenous cytoDNA in innate immune activation is well e...Endogenous cytoplasmic DNA(cytoDNA)species are emerging as key mediators of inflammation in diverse physiological and pathological contexts.Although the role of endogenous cytoDNA in innate immune activation is well established,the cytoDNA species themselves are often poorly characterized and difficult to distinguish,and their mechanisms of formation,scope of function and contribution to disease are incompletely understood.Here,we summarize current knowledge in this rapidly progressing field with emphases on similarities and differences between distinct cytoDNAs,their underlying molecular mechanisms of formation and function,interactions between cytoDNA pathways,and therapeutic opportunities in the treatment of age-associated diseases.展开更多
文摘Endogenous cytoplasmic DNA(cytoDNA)species are emerging as key mediators of inflammation in diverse physiological and pathological contexts.Although the role of endogenous cytoDNA in innate immune activation is well established,the cytoDNA species themselves are often poorly characterized and difficult to distinguish,and their mechanisms of formation,scope of function and contribution to disease are incompletely understood.
文摘Endogenous cytoplasmic DNA(cytoDNA)species are emerging as key mediators of inflammation in diverse physiological and pathological contexts.Although the role of endogenous cytoDNA in innate immune activation is well established,the cytoDNA species themselves are often poorly characterized and difficult to distinguish,and their mechanisms of formation,scope of function and contribution to disease are incompletely understood.Here,we summarize current knowledge in this rapidly progressing field with emphases on similarities and differences between distinct cytoDNAs,their underlying molecular mechanisms of formation and function,interactions between cytoDNA pathways,and therapeutic opportunities in the treatment of age-associated diseases.
