All eukaryotes including the yeast contain a lipid storage compartment which is named lipid particle,lipid droplet or oil body.Lipids accumulating in this subcellular fraction serve as a depot of energy and building b...All eukaryotes including the yeast contain a lipid storage compartment which is named lipid particle,lipid droplet or oil body.Lipids accumulating in this subcellular fraction serve as a depot of energy and building blocks for membrane lipid synthesis.In the yeast,the major storage lipids are triacylglycerols(TGs)and steryl esters(SEs).An important step in the life cycle of these non-polar lipids is their mobilization from their site of storage and channeling of their degradation components to the appropriate metabolic pathways.A key step in this mobilization process is hydrolysis of TG and SE which is accomplished by lipases and hydrolases.In this review,we describe our recent knowledge of TG lipases from the yeast based on biochemical,molecular biological and cell biological information.We report about recent findings addressing the versatile role of TG lipases in lipid metabolism,and discuss non-polar lipid homeostasis and its newly discovered links to various cell biological processes in the yeast.展开更多
基金support by the Fonds zur Förderung der wissenschaftlichen Forschung inÖsterreich(project P23029 to GD).
文摘All eukaryotes including the yeast contain a lipid storage compartment which is named lipid particle,lipid droplet or oil body.Lipids accumulating in this subcellular fraction serve as a depot of energy and building blocks for membrane lipid synthesis.In the yeast,the major storage lipids are triacylglycerols(TGs)and steryl esters(SEs).An important step in the life cycle of these non-polar lipids is their mobilization from their site of storage and channeling of their degradation components to the appropriate metabolic pathways.A key step in this mobilization process is hydrolysis of TG and SE which is accomplished by lipases and hydrolases.In this review,we describe our recent knowledge of TG lipases from the yeast based on biochemical,molecular biological and cell biological information.We report about recent findings addressing the versatile role of TG lipases in lipid metabolism,and discuss non-polar lipid homeostasis and its newly discovered links to various cell biological processes in the yeast.
