Aim: To investigate the effects of a non-steroidal anti-in-flammatory drug (NSAID) ophthalmic solution on latanoprost induced intraocular pressure (IOP) reduction in glaucoma patients. Methods: Examination was conduct...Aim: To investigate the effects of a non-steroidal anti-in-flammatory drug (NSAID) ophthalmic solution on latanoprost induced intraocular pressure (IOP) reduction in glaucoma patients. Methods: Examination was conducted on 16 eyes of 16 glaucoma patients who had been given only latanoprost for at least 6 weeks. The NSAID ophthalmic solution, sodium 2- amino- 3- (4- bromobenzoyl) phenylacetate sesquihydrate, was additionally given for 12 weeks into one eye (NSAID group), while sodium hyaluronic acid ophthalmic solution was administered into the other eye (control group) in a double masked fashion. The IOP measurement was performed before the start of additional administration of ophthalmic solutions, 2, 4, 6, 8, 10, and 12 weeks after the start of additional administration, and 2, 4, and 6 weeks after discontinuing additional administration. Results: No significant difference was observed in the IOPs before additional administration of ophthalmic solution between the NSAID group and the control group. Following the additional administration of ophthalmic solution, IOP in the NSAID group was consistently higher than that in the control group, and a maximum difference in IOP between the two groups was 1.08 (SD 1.75) mm Hg (p=0.03). This trend was observed even after additional administration was discontinued. Conclusion: NSAID ophthalmic solutionmay partly affect IOP reduction by latanoprost.展开更多
Purpose: Several characteristic personality types have been reported for glaucoma patients in previous studies. However, none of the previous studies used a common structural theory of personality. In this study, we c...Purpose: Several characteristic personality types have been reported for glaucoma patients in previous studies. However, none of the previous studies used a common structural theory of personality. In this study, we conducted a multicenter cross-sectional case-control study using the recently established five-factor model of personality structure. Methods: Personality was evaluated using the Neuroticism Extraversion Openness Five-Factor Inventory (NEO-FFI), which is a questionnaire specifically designed to test the five-factor model of personality: neuroticism (N), extraversion (E), openness (O), agreeableness (A), and conscientiousness (C). Eligible questionnaires were obtained from 196 patients with primary open-angle glaucoma (POAG) (99 men, 97 women) and 223 reference subjects with no ocular disease except cataract (87 men, 136 women). The mean score of each NEO-FFI factor for POAG patients was compared to the scores for the reference subjects. Results: Compared with the reference subjects, the mean N score was significantly higher (P=0.013), the mean scores for A and C were significantly lower (P=0.007 and P=0.001, respectively), and the mean E score tended to be lower (P=0.055) in male POAG patients. The mean E score was significantly lower (P=0.023) in female POAG patients. Conclusions: Characteristic personality traits were noted in POAG patients, and a more significant relationship was found between personality and glaucoma in men than in women.展开更多
Purpose: To determine the proportion of age-related ophthalmologic diseases discovered in a healthy Japanese adult population, as well as to evaluate the age-related changes in intraocular pressure (IOP) in this popul...Purpose: To determine the proportion of age-related ophthalmologic diseases discovered in a healthy Japanese adult population, as well as to evaluate the age-related changes in intraocular pressure (IOP) in this population during a 10- year period. Methods: Ophthalmologic surveys were conducted in 1988 and 1998 at Tamaho-cho in Yamanashi Prefecture. The target population of the first survey was 1389 subjects over 40 years of age, and of these, 1250 subjects (473 men and 777 women) participated in the survey. Their mean age was 57.8± 11.9 years. Of these 1250 subjects, 245 subjects participated in the second ophthalmologic survey in 1998. The cases of glaucoma or age-related ophthalmologic diseases developing over the intervening 10-year period were determined among the subjects who had been diagnosed with no ophthalmologic abnormalities in the 1988 survey. We also compared the IOP values of the 219 subjects who were diagnosed with no ophthalmologic abnormalities in either the 1988 or the 1998 survey. Results: The number of cases in the 1998 survey with newly discovered ocular diseases were as follows: two cases (0.82% )-of normal-tension glaucoma, two cases (0.82% ) of epiretinal membrane, one case (0.41% ) of age-related macular degeneration, one case (0.41% ) of angle-closure glaucoma, and one case (0.41% ) of branch retinal vein occlusion. The mean IOP of the 219 subjects diagnosed with no ophthalmic abnormalities in either survey was 13.88 ± 3.04 mmHg in 1988, which declined significantly to 13.16 ± 2.75 mmHg in 1998 (P< 0.0001). Conclusions: The 10-year follow-up of the 245 subjects participating in both surveys showed one or two de novo cases of age-relatedmacular degeneration, epiretinal membrane, branch retinal vein occlusion, normal-tension glaucoma, or angle- closure glaucoma. IOP was found to decline significantly with age.展开更多
文摘Aim: To investigate the effects of a non-steroidal anti-in-flammatory drug (NSAID) ophthalmic solution on latanoprost induced intraocular pressure (IOP) reduction in glaucoma patients. Methods: Examination was conducted on 16 eyes of 16 glaucoma patients who had been given only latanoprost for at least 6 weeks. The NSAID ophthalmic solution, sodium 2- amino- 3- (4- bromobenzoyl) phenylacetate sesquihydrate, was additionally given for 12 weeks into one eye (NSAID group), while sodium hyaluronic acid ophthalmic solution was administered into the other eye (control group) in a double masked fashion. The IOP measurement was performed before the start of additional administration of ophthalmic solutions, 2, 4, 6, 8, 10, and 12 weeks after the start of additional administration, and 2, 4, and 6 weeks after discontinuing additional administration. Results: No significant difference was observed in the IOPs before additional administration of ophthalmic solution between the NSAID group and the control group. Following the additional administration of ophthalmic solution, IOP in the NSAID group was consistently higher than that in the control group, and a maximum difference in IOP between the two groups was 1.08 (SD 1.75) mm Hg (p=0.03). This trend was observed even after additional administration was discontinued. Conclusion: NSAID ophthalmic solutionmay partly affect IOP reduction by latanoprost.
文摘Purpose: Several characteristic personality types have been reported for glaucoma patients in previous studies. However, none of the previous studies used a common structural theory of personality. In this study, we conducted a multicenter cross-sectional case-control study using the recently established five-factor model of personality structure. Methods: Personality was evaluated using the Neuroticism Extraversion Openness Five-Factor Inventory (NEO-FFI), which is a questionnaire specifically designed to test the five-factor model of personality: neuroticism (N), extraversion (E), openness (O), agreeableness (A), and conscientiousness (C). Eligible questionnaires were obtained from 196 patients with primary open-angle glaucoma (POAG) (99 men, 97 women) and 223 reference subjects with no ocular disease except cataract (87 men, 136 women). The mean score of each NEO-FFI factor for POAG patients was compared to the scores for the reference subjects. Results: Compared with the reference subjects, the mean N score was significantly higher (P=0.013), the mean scores for A and C were significantly lower (P=0.007 and P=0.001, respectively), and the mean E score tended to be lower (P=0.055) in male POAG patients. The mean E score was significantly lower (P=0.023) in female POAG patients. Conclusions: Characteristic personality traits were noted in POAG patients, and a more significant relationship was found between personality and glaucoma in men than in women.
文摘Purpose: To determine the proportion of age-related ophthalmologic diseases discovered in a healthy Japanese adult population, as well as to evaluate the age-related changes in intraocular pressure (IOP) in this population during a 10- year period. Methods: Ophthalmologic surveys were conducted in 1988 and 1998 at Tamaho-cho in Yamanashi Prefecture. The target population of the first survey was 1389 subjects over 40 years of age, and of these, 1250 subjects (473 men and 777 women) participated in the survey. Their mean age was 57.8± 11.9 years. Of these 1250 subjects, 245 subjects participated in the second ophthalmologic survey in 1998. The cases of glaucoma or age-related ophthalmologic diseases developing over the intervening 10-year period were determined among the subjects who had been diagnosed with no ophthalmologic abnormalities in the 1988 survey. We also compared the IOP values of the 219 subjects who were diagnosed with no ophthalmologic abnormalities in either the 1988 or the 1998 survey. Results: The number of cases in the 1998 survey with newly discovered ocular diseases were as follows: two cases (0.82% )-of normal-tension glaucoma, two cases (0.82% ) of epiretinal membrane, one case (0.41% ) of age-related macular degeneration, one case (0.41% ) of angle-closure glaucoma, and one case (0.41% ) of branch retinal vein occlusion. The mean IOP of the 219 subjects diagnosed with no ophthalmic abnormalities in either survey was 13.88 ± 3.04 mmHg in 1988, which declined significantly to 13.16 ± 2.75 mmHg in 1998 (P< 0.0001). Conclusions: The 10-year follow-up of the 245 subjects participating in both surveys showed one or two de novo cases of age-relatedmacular degeneration, epiretinal membrane, branch retinal vein occlusion, normal-tension glaucoma, or angle- closure glaucoma. IOP was found to decline significantly with age.
