Corynebacterium glutamicum is a microbial production host established in the industry 60 years ago.It is mainly used for production of feed and food amino acids.As C.glutamicum strain development has been cutting edge...Corynebacterium glutamicum is a microbial production host established in the industry 60 years ago.It is mainly used for production of feed and food amino acids.As C.glutamicum strain development has been cutting edge since its discovery,it has been engineered for production of a plethora of valuable products.This review will focus on recent developments of C.glutamicum strain engineering for biotransformation and fermentation processes towards flavor and fragrance molecules as well as pigments and sweeteners.展开更多
基金funding enabled and organized by Projekt DEAL.Support in the framework of the ERA CoBioTech project INDIE(European Union’s Horizon 2020 research and innovation programme under grant agreement No.722361)with national funding is acknowledged by KC(Dutch research council(NWO)grant number 053.80.732)and VFW(Renewable Resources Scheme(FNR)of the Federal Ministry of Food and Agriculture,Germany,grant number 22023517).NAH acknowledges funding by BMBF project KaroTec(grant number:03VP09460).
文摘Corynebacterium glutamicum is a microbial production host established in the industry 60 years ago.It is mainly used for production of feed and food amino acids.As C.glutamicum strain development has been cutting edge since its discovery,it has been engineered for production of a plethora of valuable products.This review will focus on recent developments of C.glutamicum strain engineering for biotransformation and fermentation processes towards flavor and fragrance molecules as well as pigments and sweeteners.