Invasive micropapillary carcinoma(IMPC)is a rare histological type of tumor,first described in invasive ductal breast cancer,than in malignancies in other organs such as lungs,urinary bladder,ovaries or salivary gland...Invasive micropapillary carcinoma(IMPC)is a rare histological type of tumor,first described in invasive ductal breast cancer,than in malignancies in other organs such as lungs,urinary bladder,ovaries or salivary glands.Recent literature data shows that this histological lesion has also been found in cancers of the gastrointestinal system.The micropapillary components are clusters of neoplastic cells that closely adhere to each other and are located in distinct empty spaces.Moreover,clusters of neoplastic cells do not have a fibrousvascular core.The IMPC cells show reverse polarity resulting in typical‘’inside-out’’structures that determines secretary properties,disturbs adhesion and conditions grade of malignancy in gastrointestinal(GI)tract.Invasive micropapillary carcinoma in this location is associated with metastases to local lymph nodes and lymphovascular invasion.IMPC can be a prognostic factor for patients with cancers of the stomach,pancreas and with colorectal cancer since it is related with diseasefree and overall survival.The purpose of this review is to present the characterization of invasive micropapillary carcinoma in colon,rectum,stomach and others site of GI tract,and to determine the immunohistological indentification of IMPC in those localization.展开更多
AIM: To evaluate the expression of Bcl-xL, Bak, and Bax proteins in correlation with particular clinico-histopathological parameters, including tumor invasion front, in patients with colorectal cancer. METHODS: The ex...AIM: To evaluate the expression of Bcl-xL, Bak, and Bax proteins in correlation with particular clinico-histopathological parameters, including tumor invasion front, in patients with colorectal cancer. METHODS: The expression of these proteins was evaluated with the use of the immunohistochemical method in 50 primary tumors. RESULTS: According to observations, a low expression of Bax and Bak proteins is related to the localization of the tumor in the rectum(P < 0.05 and P < 0.05 respectively), which may explain an increased incidence of colorectal cancer in this area. A positive expression of Bax protein also correlates with the presence of cancer cell infiltration to lymph and blood vessels(P < 0.05), which may suggest the participation of this protein in the early stages of colorectal cancer progression. Moreover, a positive expression of Bcl-xL protein correlated with a positive expression of Bak protein. This may suggest a greater participation of Bcl-xL protein in the inhibition of the proapoptotic Bak protein, but not the Bax protein. CONCLUSION: Bax protein is probably very significant in the cancerogenesis mechanism in the large intestine.展开更多
文摘Invasive micropapillary carcinoma(IMPC)is a rare histological type of tumor,first described in invasive ductal breast cancer,than in malignancies in other organs such as lungs,urinary bladder,ovaries or salivary glands.Recent literature data shows that this histological lesion has also been found in cancers of the gastrointestinal system.The micropapillary components are clusters of neoplastic cells that closely adhere to each other and are located in distinct empty spaces.Moreover,clusters of neoplastic cells do not have a fibrousvascular core.The IMPC cells show reverse polarity resulting in typical‘’inside-out’’structures that determines secretary properties,disturbs adhesion and conditions grade of malignancy in gastrointestinal(GI)tract.Invasive micropapillary carcinoma in this location is associated with metastases to local lymph nodes and lymphovascular invasion.IMPC can be a prognostic factor for patients with cancers of the stomach,pancreas and with colorectal cancer since it is related with diseasefree and overall survival.The purpose of this review is to present the characterization of invasive micropapillary carcinoma in colon,rectum,stomach and others site of GI tract,and to determine the immunohistological indentification of IMPC in those localization.
文摘AIM: To evaluate the expression of Bcl-xL, Bak, and Bax proteins in correlation with particular clinico-histopathological parameters, including tumor invasion front, in patients with colorectal cancer. METHODS: The expression of these proteins was evaluated with the use of the immunohistochemical method in 50 primary tumors. RESULTS: According to observations, a low expression of Bax and Bak proteins is related to the localization of the tumor in the rectum(P < 0.05 and P < 0.05 respectively), which may explain an increased incidence of colorectal cancer in this area. A positive expression of Bax protein also correlates with the presence of cancer cell infiltration to lymph and blood vessels(P < 0.05), which may suggest the participation of this protein in the early stages of colorectal cancer progression. Moreover, a positive expression of Bcl-xL protein correlated with a positive expression of Bak protein. This may suggest a greater participation of Bcl-xL protein in the inhibition of the proapoptotic Bak protein, but not the Bax protein. CONCLUSION: Bax protein is probably very significant in the cancerogenesis mechanism in the large intestine.
