期刊文献+
共找到3篇文章
< 1 >
每页显示 20 50 100
Could serotonin play a role in abnormal brain outcomes in fetal growth restriction? 被引量:2
1
作者 kate beecher Julie A.Wixey 《Neural Regeneration Research》 SCIE CAS CSCD 2023年第3期543-544,共2页
Fetal growth restriction(FGR)describes a fetus that has not grown to its expected biological potential in utero.FGR can result from maternal,fetal,or placental complications,though it is commonly caused by placental i... Fetal growth restriction(FGR)describes a fetus that has not grown to its expected biological potential in utero.FGR can result from maternal,fetal,or placental complications,though it is commonly caused by placental insufficiency.The prolonged hypoxic environment the FGR fetus is exposed to has detrimental effects on the newborn,which extends to adverse long-term neurological outcomes in a significant proportion of FGR infants(Malhotra et al.,2019).Unfortunately,there are currently no therapies to reduce the adverse neurological outcomes in FGR.Neuronal injury is evident in the FGR brain,and therefore understanding which neurons are lost and how they are lost will aid in the selection of treatment options for FGR. 展开更多
关键词 FETAL FETUS INSUFFICIENCY
下载PDF
Combined VEGF/PDGF improves olfactory regeneration after unilateral bulbectomy in mice 被引量:2
2
作者 kate beecher Louise M.Hafner +2 位作者 Jenny Ekberg James A.St.John Fatemeh Chehrehasa 《Neural Regeneration Research》 SCIE CAS CSCD 2018年第10期1820-1826,共7页
The olfactory receptor neurons lining the nasal cavity have a remarkable capacity to regenerate throughout life. They are replenished continuously and their axons make new connections within the olfactory bulb. Howeve... The olfactory receptor neurons lining the nasal cavity have a remarkable capacity to regenerate throughout life. They are replenished continuously and their axons make new connections within the olfactory bulb. However, some factors such as head trauma and skull base surgery damage the olfactory nerve which lead to olfactory dysfunction. Losing the sense of smell has considerable effects on quality of life and life-expectancy. Therefore, there is a clear need to find a treatment for olfactory dysfunction. One such potential treatment is growth factor therapy which showed promising results in the spinal cord and brain injuries. The aim of the present study was to investigate whether combined delivery of two growth factors, vascular endothelial growth factor and platelet-derived growth factor treatment can improve the olfactory neurons regeneration in mice. The degeneration of the olfactory neurons was induced by unilateral bulbectomy. The treatment group received 1.5 μg of the combined growth factors intranasally, while the control injured group received saline. Growth factor treatment significantly increased the number of immature neurons at 5 and 7 days post injury and also the number of mature olfactory neurons at 10 and 14 days post bulbectomy. Regenerating axons extended over a larger volume in the operated cavity in the treatment group compared to control group at 14 days post bulbectomy. The growth factor treatment also significantly reduced astrocytic glia scar in the operated cavity. The results indicate that the combined delivery of the growth factors has the potential to improve olfactory dysfunction. 展开更多
关键词 ASTROCYTES olfactory bulb glial scar AXON growth factors neuron
下载PDF
Factors that modulate olfactory dysfunction 被引量:2
3
作者 kate beecher James A.St John Fatemeh Chehrehasa 《Neural Regeneration Research》 SCIE CAS CSCD 2018年第7期1151-1155,共5页
The olfactory system is one of a few areas in the nervous system which is capable of regeneration throughout the life.Olfactory sensory neurons reside in the nasal cavity are continuously replenished with new neurons ... The olfactory system is one of a few areas in the nervous system which is capable of regeneration throughout the life.Olfactory sensory neurons reside in the nasal cavity are continuously replenished with new neurons arising from stem cells.Some factors such as aging,neurodegenerative diseases,head trauma,brain tumor extraction and infection cause olfactory dysfunction which significantly influences physical wellbeing,quality of life,mental health,nutritional status,memory processes,identifying danger and is associated with increased mortality.Therefore,finding a treatment to improve olfactory dysfunction is needed.Recent research efforts in the field have shown some very promising new approaches to treat olfactory dysfunction.This review explores the current studies that have addressed therapeutic approaches to improve olfactory neuron regeneration based on cell transplantation therapy,modulation of physiological olfactory dysfunction and drug treatments. 展开更多
关键词 olfactory neuron regeneration anosmia loss of smell degeneration bulbectomy ensheathing cells growth factor epithelium receptor
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部