The differentiation and functional plasticity of T cells are transcriptionally and epigenetically regulated by signals imposed by the local cytokine milieu and a variety of additional factors,including vitamins.Vitami...The differentiation and functional plasticity of T cells are transcriptionally and epigenetically regulated by signals imposed by the local cytokine milieu and a variety of additional factors,including vitamins.Vitamin C has pleiotropic functions in the immune system.It exerts antioxidant activity,can directly kill selected tumor targets,promotes early T-cell differentiation,and enhances Th1 cytokine production in mature T cells[1,2].展开更多
基金This work was supported by a grant from the Deutsche Forschungsgemeinschaft(Ka502/19-3 to DK).
文摘The differentiation and functional plasticity of T cells are transcriptionally and epigenetically regulated by signals imposed by the local cytokine milieu and a variety of additional factors,including vitamins.Vitamin C has pleiotropic functions in the immune system.It exerts antioxidant activity,can directly kill selected tumor targets,promotes early T-cell differentiation,and enhances Th1 cytokine production in mature T cells[1,2].
