The objective was to evaluate the pure-tone audiogram-based screening protocols in VS diagnostics.We retrospectively analyzed presenting symptoms,pure tone audiometry and MRI finding from 246 VS patients and 442 contr...The objective was to evaluate the pure-tone audiogram-based screening protocols in VS diagnostics.We retrospectively analyzed presenting symptoms,pure tone audiometry and MRI finding from 246 VS patients and 442 controls were collected to test screening protocols(AAO-HNS,AMCLASS-A/B,Charing Cross,Cueva,DOH,Nashville,Oxford,Rule3000,Schlauch,Seattle,Sunderland)for sensitivity and specificity.Results were pooled with data from five other studies,and analysis of sensitivity,specificity and positive likelihood ratio(LR+)for each protocol was performed.Our results show that protocols with significantly higher sensitivity(AMCLASS-A/B,Nashville)show also significantly lowest specificity,and tend to have low association(positive likelihood ratio,LR+)to the VS.The highest LR+was found for protocols AAO-HNS,Rule3000 and Seattle.In conclusions,knowing their properties,screening protocols are simple decision-making tools in VS diagnostic.To use the advantage of the highest sensitivity,protocols AMCLASS-A+B or Nashville can be of choice.For more reasonable approach,applying the protocols with high LR+(AAO-HNS,Rule3000,Seattle)may reduce the overall number of MRI scans at expense of only few primarily undiagnosed VS.展开更多
文摘The objective was to evaluate the pure-tone audiogram-based screening protocols in VS diagnostics.We retrospectively analyzed presenting symptoms,pure tone audiometry and MRI finding from 246 VS patients and 442 controls were collected to test screening protocols(AAO-HNS,AMCLASS-A/B,Charing Cross,Cueva,DOH,Nashville,Oxford,Rule3000,Schlauch,Seattle,Sunderland)for sensitivity and specificity.Results were pooled with data from five other studies,and analysis of sensitivity,specificity and positive likelihood ratio(LR+)for each protocol was performed.Our results show that protocols with significantly higher sensitivity(AMCLASS-A/B,Nashville)show also significantly lowest specificity,and tend to have low association(positive likelihood ratio,LR+)to the VS.The highest LR+was found for protocols AAO-HNS,Rule3000 and Seattle.In conclusions,knowing their properties,screening protocols are simple decision-making tools in VS diagnostic.To use the advantage of the highest sensitivity,protocols AMCLASS-A+B or Nashville can be of choice.For more reasonable approach,applying the protocols with high LR+(AAO-HNS,Rule3000,Seattle)may reduce the overall number of MRI scans at expense of only few primarily undiagnosed VS.
